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OpportunityAnalyzer: Acute Myeloid Leukemia (AML) - Opportunity Analysis and Forecasts to 2017
Date:11/19/2013


4.3.2 Forecast Assumptions and Methods 53
4.3.3 Sources Not Used 57
4.4 Epidemiological Forecast of Acute Myeloid Leukemia (2012–2022) 58
4.4.1 Incident Cases of AML 58
4.4.2 Incident Cases of AML by Age 59
4.4.3 Incident Cases of AML by Sex 61
4.4.4 Age-Standardized Incidence of AML 63
4.4.5 Incident Cases of AML Subtypes 64
4.4.6 Incident Cases of AML Subtypes by Age 68
4.4.7 Incident Cases of AML with Mutations in the FLT3 Gene 69
4.4.8 Incident Cases of AML by Risk Group Classifications 71
4.4.9 Five-Year Prevalent Cases of AML 75
4.4.10 Five-Year Prevalent Cases of AML by Age 78
4.4.11 Five-Year Prevalent Cases of APL and MDS/Therapy-Related AML 79
4.4.12 Five-Year Prevalent Cases of APL and MDS/Therapy-Related AML by Age 81
4.5 Discussion 83
4.5.1 Epidemiological Forecast Insight 83
4.5.2 Limitations of the Analysis 84
4.5.3 Strengths of the Analysis 84
5 Disease Management 85
5.1 Diagnosis 85
5.2 Response Criteria 86
5.3 General Treatment Overview 87
5.3.1 Younger AML Patients 89
5.3.2 Older AML Patients 91
5.4 Hematopoietic Stem Cell Transplant 93
5.5 Monitoring for Residual Disease 95
5.6 APL 96
6 Current Treatment Options 98
6.1 Overview 98
6.2 Product Profiles – Major Brands 101
6.2.1 Cytarabine 101
6.2.2 Dacogen (decitabine) 105
6.2.3 Vidaza (azacitidine) 110
6.2.4 Other Therapeutic Agents 115
7 Unmet Needs Assessment and Opportunity Analysis 117
7.1 Overview 117
7.2 Unmet Needs Analysis 118
7.2.1 Unmet Need: Therapies that Prolong the OS of AML Patients 118
7.2.2 Unmet Need: The Elimination of Residual Disease 120
7.2.3 Unmet Need: Therapies that Achieve Durable CR in AML Patients 121
7.2.4 Unmet Need: Safety 121
7.2.5 Unmet Need: Maintenance Therapies 122
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