Navigation Links
Opening the data bank -- scientists try to match new protein structures
Date:11/7/2011

Imagine playing Go Fish with 3,000 cards.

Scientists at Rochester Institute of Technology and Dowling College are engaged in a similar game with higher stakes. Instead of cards, they are matching the protein to the job it performs in the human body. Their research could lead to drugs that target proteins and switch on or off specific functions associated with various diseases.

The three-year study is funded by a $417,000 grant from the National Institutes of Health's National Institute of General Medical Sciences and furthers research started in 2006 by Paul Craig, professor in the Department of Chemistry at RIT, and Herbert Bernstein, professor in the Department of Mathematics and Computer Science at Dowling College, in Long Island, N.Y.

Proteins are like nanomachines in the human body that carry out their missionssuch as digesting fats and sugars in muscles, or carrying oxygenand then rapidly degrade. Likewise, rogue proteins can do terrible things. A misshaped protein is like a hastily folded roadmap shoved into a glove compartment, leading to detours down roads of disease. Creutzfeldt-Jakob Disease, or mad cow disease, for instance, results from proteins misfolded into infectious prions.

Students from both universities work with Craig and Bernstein to identify the biological functions of each protein based on the shape or fold of its enzymes. Approximately 75,000 compounds in the Research Collaboratory for Structural Biology Protein Data Banka repository of biological structures of proteins, nucleic acids and complex assemblieshave already been assigned functions. The RIT-Dowling team will investigate the structural coordinates of the remaining 3,000 proteins in the bank.

They will compare proteins from the bank with a library of 400 protein motifs associated with known functions from the Catalytic Site Atlas database, focusing on amino acids and their spatial relationships that dictate a protein's specific missi
'/>"/>

Contact: Susan Gawlowicz
smguns@rit.edu
585-475-5061
Rochester Institute of Technology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New scarless surgery takes out tumors through natural skull opening
2. Heart valve replacement without opening the chest gives new option for non-operable patients
3. Deaths from drug overdose decline 35 percent after the opening of supervised injection site
4. Overdose deaths down 35 percent after opening of Vancouvers supervised injection site: UBC-BC-CfE study
5. Vein-Opening Treatment for MS Stirs Controversy
6. Scientists develop designer protein, opening new door in cancer research
7. Bling My Sling LL Announces Website Launch - A fashionable arm sling manufacturer, announce the opening of their new website bling-my-sling.com
8. Grand Opening of GreenProductsandGifts.com Online Store Offering Eco Friendly Gifts that are Proudly Made in the USA
9. Experts honored at EAU opening ceremony
10. Dreambikes Announces Grand Opening Event
11. Azia Medical Spa in Birmingham, AL to Host Two Day Grand Opening Event March 25 and March 26, 2010.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... ... it comes to undergoing a hair transplant, most patients have donor hair moved from one ... the hair on top of the scalp, as well as filling in areas missing hair, ... on other areas of their head. , What about patients who have a limited, or ...
(Date:8/31/2015)... ... August 31, 2015 , ... India ... new “ InstantQuote ” tool, which summarizes all available plans, plan maximums, pre-existing ... tool is designed to help India Network members make an informed decision regarding ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... The Lisle ... Firm Partner William Scott has been nominated by his peers to earn a “Leading ... than five percent of attorneys in the state of Illinois. The nomination process is ...
(Date:8/31/2015)... New York, NY (PRWEB) , ... August 31, ... ... on Malignant Mesothelioma is a one-day event geared to patients and family ... and presented by local and regional mesothelioma experts. The conference is a collaborative ...
(Date:8/31/2015)... ... August 31, 2015 , ... CareSource, ... and Corporate Communications. In this capacity, Michael will provide strategic leadership for CareSource’s ... leader in consumer-focused programs that have contributed to the company’s rapid growth. As ...
Breaking Medicine News(10 mins):Health News:Body Hair Transplants to Help Achieve a Full Head of Hair 2Health News:India Network proudly launches the new InstantQuote tool to help choose right visitor health insurance with pre-existing conditions to US bound visitors 2Health News:DuPage County Family Law Attorney Named Illinois Leading Lawyer 2Health News:New York Experts on Mesothelioma Come Together at Memorial Sloan Kettering Cancer Center 2Health News:New York Experts on Mesothelioma Come Together at Memorial Sloan Kettering Cancer Center 3Health News:CareSource Names Vice President, Marketing and Corporate Communications 2
... first of its kind, designed to measure the safety ... deficit/hyperactivity disorder// (ADHD) with methylphenidate (Ritalin), has revealed that ... cause harm. The study also revealed that it is ... sensitive than older children to the side effects of ...
... explained the recent improvements in the treatment of amyotrophic lateral ... paralysis. It is observed that people with the disease die ... actually stop working. Despite all the claims, cure for ALS ... disease. ,During the study, human fetal stem cells ...
... crumbling under the mounting pressure of dengue. Safdarjung Hospital ... patients being referred to AIIMS and the Red Cross. ... are given platelets only on the condition of their ... for the required platelets. Dr Santosh at the Dengue ...
... has confirmed that herceptin, a drug used for treating ... criticism// over the decision. The deputy medical director of ... expensive and funding could not be justified. The recommendation ... arrived at after complete investigation of the evidence. ...
... some valuable information which would definitely help us to ... an autistic person is blue printed. ,One ... by autism a developmental disorder typically characterized by exhibiting ... ,Lead researcher Dr Michael Murias, from the University of ...
... closet, as a virulent breast cancer strain that can be ... Among the many types of breast cancer, HER2, an aggressive ... 5 women. , ,HER2, which represents the human epidermal ... particular gene that takes care of cell growth, division and ...
Cached Medicine News:Health News:Reduced Doses of Medication Beneficial to Preschoolers with ADHD 2Health News:Reduced Doses of Medication Beneficial to Preschoolers with ADHD 3Health News:Mounting Pressure of Dengue in Delhi Hospitals 2
(Date:8/31/2015)... Aug. 31, 2015  Asterias Biotherapeutics, Inc. (NYSE ... emerging field of regenerative medicine, today announced that ... Chicago -based Rush University Medical Center ... of escalating doses of AST-OPC1 (oligodendrocyte progenitor cells) ... complete cervical spinal cord injury (SCI). This represents ...
(Date:8/31/2015)...   BioLife Solutions , Inc. (NASDAQ: ... of proprietary clinical grade cell and tissue ... media and a related cloud hosted biologistics ... shippers ("BioLife" or the "Company"), today announced ... company focused on developing and commercializing novel therapeutics ...
(Date:8/28/2015)... JACKSONVILLE, Fla. , Aug. 28, 2015  With ... reaching deadlier heights, Jacksonville ... Philip Hemphill is helping to explain why ... Fentanyl is approximately 40 to 50 times more potent ... by recreational users as heroin, the risk of death ...
Breaking Medicine Technology:Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 4Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 5Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 6BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 2BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 3BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 4BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 5Lakeview Health's Dr. Philip Hemphill Explains Why Heroin Addicts Are Now Dying of Fentanyl Overdoses 2
... use with the Moto Alpha unit, these new pads ... in which several successive runs may be sealed with ... to prevent a microplate from sticking to the block ... level of sealing performance, which means you can use ...
... Designed for use with the Moto Alpha unit, these ... cycle sequencing, in which several successive runs may be ... Alpha unit is engineered to prevent a microplate from ... pads provide an improved level of sealing performance, which ...
Microseal 'M' mats, seals 96-well plates, reusable, pkg of 10...
Omniseal TD mat. Reusable rubber mat for sealing PCR plates. 5 pk....
Medicine Products: