Navigation Links
Open access initiative reveals drug hits for deadly neglected tropical diseases
Date:11/13/2012

[Geneva, Switzerland 13 November 2012] - The Drugs for Neglected Diseases initiative (DNDi) and Medicines for Malaria Venture (MMV) announce today the identification of three chemical series targeting the treatment of deadly neglected tropical diseases (NTDs), through DNDi's screening of MMV's open access Malaria Box. The resulting DNDi screening data are among the first data generated on the Malaria Box to be released into the public domain, exemplifying the potential of openly sharing drug development data for neglected patients.

The open access Malaria Box is an MMV initiative launched in December 2011 to catalyse drug discovery for malaria and neglected diseases. It contains 400 molecules, selected by experienced medicinal chemists to offer the broadest chemical diversity possible and is available free of charge. In return, MMV requests that any data gleaned from research on the Malaria Box are shared in the public domain within two years. To date, more than 100 Malaria Boxes have been delivered to over 20 countries for research on diseases including malaria, neglected diseases, HIV and cancer.

DNDi, in partnership with the Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, screened all the compounds in the Malaria Box against the parasites responsible for the three NTDs on which DNDi mainly focuses: sleeping sickness (human African trypanosomiasis), leishmaniasis (including visceral leishmaniasis, or kala azar, also known as black fever), and Chagas disease. This initial screen identified two potential drug series for the treatment of sleeping sickness and one for leishmaniasis. The DNDi screens have yielded valuable information that will strengthen DNDi's research pipeline. All the biological data from DNDi's screen, together with the existing preliminary data from MMV, are now publicly available on the open-source ChEMBL '/>"/>

Contact: Oliver Yun
oyun@dndi.org
646-266-5216
Drugs for Neglected Diseases Initiative
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Image share project gives patients and physicians anytime, anywhere access to medical images
2. Equal access to care helps close survival gap for young African-American cancer patients
3. Premier issue of BioResearch Open Access launched by Mary Ann Liebert Inc. publishers
4. World Health Assembly endorses new plan to increase global access to vaccines
5. FDA Approves SonixGPS Needle Guidance Technology for Vascular Access Procedures
6. Researchers offer new approach to track former prisoners access to community HIV care
7. Revised geographic adjustments could improve accuracy of Medicare payments, will not solve access, quality problems
8. Access to clinical trials drives dramatic increases in survival from childhood cancer
9. Disabled Americans Battle for Access to Hotel Pools
10. Expanding Access to Medicaid Would Save Lives: Study
11. The ACCESS-EU study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... 21, 2014 Living in a quality ... that comes along with it. A quality Home Owners ... such amenities are available. , Simpson ... Georgia and Community Association Management, LLC made a recent ... Company to provide an additional amenity for their neighborhood. ...
(Date:8/21/2014)... arteries of chronic kidney disease patients may be a ... new study in the Journal of the American ... the Johns Hopkins Bloomberg School of Public Health assert ... of subclinical atherosclerosis in predicting the risk of heart ... percent of all patients with chronic kidney disease (CKD) ...
(Date:8/21/2014)... Dallas, TX (PRWEB) August 21, 2014 ... August 20 entertained residents with dementia at Silverado Turtle ... Improv Troupe, which consists of entertainers ranging from ages ... each time they perform their 40-minute set. The troupe's ... makes it universal and allows them to touch audiences ...
(Date:8/21/2014)... August 21, 2014 The City of ... for entertainment and programming for its inaugural “Re:Imagine Garden ... October 12, 2014, from 11 a.m. to 4 p.m., ... all cars and the downtown will be filled with ... by Community Arts Resources (CARS), for all to enjoy. ...
(Date:8/21/2014)... Among seniors, dimming vision may be tied to poorer survival, ... people, aged 65 to 84, who were assessed when they ... years later. Vision loss over time was associated with ... study period, the researchers reported. Although the study couldn,t ... Purdue University in West Lafayette, Ind., offered up some theories ...
Breaking Medicine News(10 mins):Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 3Health News:Measuring calcium buildup to predict heart disease in those with chronic kidney disease 2Health News:Unicorn Clearance Improv Troupe Brings Laughter to Residents with Dementia at Silverado Memory Care 2Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 2Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 3Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 4Health News:Failing Vision Tied to Shorter Lifespans for Seniors 2
... new study by Ohio State University researchers has shown ... are not being managed appropriately.,The researchers who looked at ... patients' own descriptions of anxiety after a heart attack ... doctors do not match. In the group of,participants it ...
... been found for detecting upper urinary tract transitional cell ... Canada. This method checks for fibrinogen/fibrin degradation products. It ... to standard urinary cytology. The Researchers compared the efficacy ... cytology in establishing the diagnosis// of transitional cell carcinoma ...
... came up in 1971 argued that people react to ... eventually return to a stable level of well-being. Researchers ... France and England confirmed this theory based on a ... on life satisfaction. 24,000 individuals were followed for 15 ...
... first of its kind study compared a group of whiplash patients ... who suffered a whiplash injury had pain in the neck, head, ... a year. In the study of the two groups, pain in ... a month while in the whiplash injury group patients were still ...
... Examination Survey has now uncovered a link between Periodontal ... of gum disease that causes infection and inflammation of ... of the study where divided into two groups, depending ... an indicator of the presence of periodontal disease. They ...
... Live cancer is one of the most aggressive cancers worldwide ... countries due to hepatitis infection and aflatoxin contamination of foodstuffs. ... Researchers in the US and China have been studying gene ... and found a way of detecting tumors that spread. They ...
Cached Medicine News:
(Date:8/21/2014)... 21, 2014  eRelevance Corporation ( www.erelevancecorp.com ), ... that it has completed integration with Nextech, a ... Surgery and Dermatology practices. "Integration allows ... healthcare practices using Nextech," stated Bob Fabbio ... information from the EMR we are able to ...
(Date:8/21/2014)... 2014  Decision Resources Group finds that, for ... Brazil and Mexico ... prescribe long-acting beta-agonist (LABA)- and long-acting muscarinic antagonist ... current severe cost/coverage constraints. Therefore, new brands of ... launch in these countries—which will considerably expand the ...
(Date:8/21/2014)...  Zacks.com announces the list of stocks featured in the ... the latest news and events impacting stocks and the financial ... HPQ - Free Report ), IBM (NYSE: IBM ... - Free Report ), GlaxoSmithKline plc (NYSE: GSK - ... - Free Report ). Today, Zacks is promoting ...
Breaking Medicine Technology:eRelevance Corporation Integrates with Nextech Electronic Medical Records 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 2The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 3The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 4The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 5The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 6The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 7The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 8The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 9The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 10The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 11
... Inc., a privately-held developer and marketer of the VerifyNow ... for measuring platelet reactivity to multiple antiplatelet agents, announced ... Portola Pharmaceuticals, Inc. to develop and supply the VerifyNow ... The VerifyNow System is widely used by practicing ...
... SUNNYVALE, Calif., March 2, 2011 Pharmacyclics, Inc. (Nasdaq: ... of PCI-45292, a Btk inhibitor with exceptionally potent anti-arthritis ... results from the current set of preclinical toxicology studies. ... candidate identified within approximately 6 months. ...
Cached Medicine Technology:Accumetrics Signs Development & Supply Agreement With Portola Pharmaceuticals, Inc. 2Update on Preclinical Finding and Development Timeline for PCI-45292 2Update on Preclinical Finding and Development Timeline for PCI-45292 3
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Fenestrated large type 1/1 (mm), opening width 8.0 mm and length 7.5 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Fenestrated large type 1/1 (mm), opening width 7.0 mm and length 10 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 10.0 mm and length 10 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 8.0 mm and length 9 mm....
Medicine Products: