Navigation Links
Open Biosystems Launches Decode RNAi Viral Screening Pools for Low-Cost Genome-Scale RNAi Screens
Date:4/15/2008

HUNTSVILLE, Ala., April 15 /PRNewswire/ -- Open Biosystems, Inc., focused on the commercialization of leading-edge life science research tools for drug discovery, today announced the availability of new Decode(TM) RNAi viral screening pools for multiplexed RNAi screens. This novel offering allows researchers access to genome-scale RNAi screens and the ability to rapidly screen through thousands of genes at a time utilizing PCR and traditional sequencing.

(Logo: http://www.newscom.com/cgi-bin/prnh/20070423/CLM143LOGO )

The first Decode RNAi viral screening set has been created using Open Biosystems' GIPZ lentiviral shRNAmir library validated in its ability to produce effective knockdown even when expressed from a single integration event in target cells. This pooled screening set targets the entire human genome in a ready-to-use lentiviral pool format, extending RNAi screening to primary and non-dividing cells. The Decode RNAi product will be expanded to include shRNAmir pools providing choices in promoters, fluorescent markers and type of viral vector increasing the ability to perform genome scale RNAi screening in all cell types and assays.

Two recent publications from Dr. Greg Hannon and Dr. Steve Elledge, developers of the shRNAmir technology for RNAi, display the power of multiplexed RNAi screening using shRNAmir pools. They were able to identify genes that are selectively required by certain cancer cells but not by normal cells. Identification of selective vulnerabilities in specific cancer cells is key to the development of alternative cancer therapeutics.

Dr. Ricky Johnstone, Group Leader of Gene Regulation at the Peter MacCallum Cancer Center said, "As beta users of the Open Biosystems' Decode RNAi viral pools, we are very happy with its convenient format, knockdown performance in multiplexed RNAi screens, as well as, its ability to transduce many different cell lines. Researchers at the Peter Mac are very excited about the possibilities of being able to comb through thousands of genes at a time to further our understanding of cancer biology and ultimately the search for novel cancer therapeutics."

"The Decode RNAi pooled libraries take RNAi screening to the bench top," said Troy Moore, Chief Technology Officer at Open Biosystems. "Until now, genome-scale RNAi screens could only be performed by large labs or institutions that had spent millions of dollars in equipment and reagents. The Decode RNAi viral screening pools makes it possible for individual laboratories to do these studies without the labor and high cost of robotics. Open Biosystems continues to arm the research community with the RNAi tools necessary to propel research efforts to the next level. The Decode RNAi viral screening pools give researchers at all levels access to genome-scale RNAi screens that may lead to novel therapeutics and treatment options for human disease."

Decode RNAi viral screening pools are available immediately as single use screening kits for positive selection screening. For additional information, please contact info@openbiosystems.com.

About Open Biosystems

Open Biosystems, Inc. develops manufactures and markets genomic research tools to scientists and researchers in corporate, academic and government laboratories. These research tools provide investigators with standardized high-quality genes, RNAi and antibodies for interrogating gene function in relation to oncology, neuroscience and metabolic disorders. Founded in 2001, Open Biosystems is headquartered in Huntsville, Alabama. For more information and details for ordering, please visit: http://www.openbiosystems.com.


'/>"/>
SOURCE Open Biosystems, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. Open Biosystems Open Access RNAi Program Continues to Gain Momentum Worldwide
2. Us TOO Launches National SEA Blue Campaign for Prostate Cancer Awareness Month
3. UPMC Health Plan Launches New Personal Health Record
4. HealthInsuranceFinders.com Launches Video Contest for Young Directors
5. Academy of General Dentistry Launches Campaign to Focus on Tooth Erosion
6. Keeping Kids Healthy and Fit: The New York Kids Club Launches a Revolutionary New Fitness Program
7. Patient Advocate Foundation Launches Program to Help Uninsured Virginians with Chronic, Debilitating and Life-Threatening Illness Access Quality Healthcare
8. Mannatech Launches Phase One of New Sales and Training Tools
9. Coalition for Pulmonary Fibrosis Launches Aggressive Ad Campaign Directed at United States Congress
10. Actavis Launches Carvedilol Tablets in the U.S.
11. MedQuist Re-launches New, Improved Web Site
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... ... the United States, named Dr. Sesan Ogunleye, as the Medical Director of its new ... the facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, ...
(Date:6/24/2016)... ... , ... A recent article published June 14 on E Online ... on to state that individuals are now more comfortable seeking to undergo not only ... calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Global law ... magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition are ... , Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The ... published in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
(Date:6/23/2016)... -- Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... . ... ... ... Astellas is ...
Breaking Medicine Technology: