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Onyx Pharmaceuticals Announces Management Changes
Date:10/4/2007

cializing and developing Nexavar(R), a small molecule drug, with Bayer HealthCare Pharmaceuticals Inc. Nexavar has been approved for the treatment of advanced kidney cancer. For more information about Onyx's pipeline and activities, visit the company's website at: http://www.onyx-pharm.com.

Nexavar(R) (sorafenib) tablets is a registered trademark of Bayer HealthCare Pharmaceuticals Inc.

This news release contains "forward-looking statements" within the meaning of the federal securities laws. These forward-looking statements include, without limitation, statements regarding the planned commercial launch of Nexavar as a treatment for liver cancer and the anticipated contributions of Onyx's management team. These statements are subject to risks and uncertainties that could cause actual results and events to differ materially from those anticipated. These risks and uncertainties include, without limitation, the risks (i) that Nexavar may never be approved for use in liver cancer or that its approval may be significantly delayed, and (ii) that we depend upon our collaborative relationship with Bayer to manufacture and to further develop and commercialize Nexavar. These and other risk factors are discussed under "Risk Factors" in Onyx's Annual Report on Form 10-K for the year ended December 31, 2006, as well as Onyx's subsequent quarterly reports on Form 10-Q, filed with the Securities and Exchange Commission. Readers are cautioned not to place undue reliance on these forward-looking statements that speak only as of the date of this release. Onyx undertakes no obligation to update publicly any forward-looking statements to reflect new information, events, or circumstances after the date of this release except as required by law.


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SOURCE Onyx Pharmaceuticals, Inc.
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