Navigation Links
Only Severely Depressed Benefit From Antidepressants: Study
Date:2/27/2008

But some mental-health experts dispute the findings

TUESDAY, Feb. 26 (HealthDay News) -- While popular antidepressants such as Prozac are widely prescribed for people with varying degrees of depression, the drugs are only effective for those with the most severe depression, a new study suggests.

"Although patients get better when they take antidepressants, they also get better when they take a placebo, and the difference in improvement is not very great," lead researcher Irving Kirsch, a professor of psychology at the University of Hull in Great Britain, said in a prepared statement. "This means that depressed people can improve without chemical treatments," he added.

In the study, Kirsch and his colleagues collected data on 35 clinical trials of drugs called selective serotonin reuptake inhibitors, or SSRIs, whose results had been submitted to the U.S. Food and Drug Administration. The antidepressants included in the trials were fluoxetine (Prozac), venlafaxine (Effexor), nefazodone (Serzone), and paroxetine (Seroxat/Paxil).

An analysis of the data showed that patients taking antidepressants fared no better than patients receiving a placebo. This appeared to be the case whether the patients were mildly or moderately depressed.

The drugs only seemed to benefit a small group of patients -- those with the severest depression when the study began.

Based on these results, there appears to be little reason to prescribe these antidepressants to anyone but the most severely depressed patients, the study authors concluded.

The findings were published online Feb. 25 in the journal PLoS Medicine.

Dr. Nada Stotland, president-elect of the American Psychiatric Association, said she wasn't surprised that the study found that not every antidepressant works for every patient. Many people who are depressed don't respond to the first antidepressant they try. It can take up to an average of three different antidepressants until one works for a particular patient, she said.

"Medication helps some, but not all, people with depression," Stotland said in a prepared statement. "For people with mild to moderate depression, psychotherapy can work as well as medication. Studies have shown that between 70 and 80 percent of people can and do get better with a combination of treatment approaches, which will often include individual therapy, family therapy and/or medication.

"Therefore, testing any single antidepressant on a group of depressed individuals will show that many of them do not improve," Stotland added. "There is a small group of depressed individuals who do not respond to any antidepressant."

The new study highlights the fact that treatment for depression needs to be tailored to an individual, and that the most effective treatment will often include multiple approaches, Stotland said. The study results also suggest that more long-term follow-up trials are needed to determine which patients are most likely to benefit from specific therapies.

"Some of the most exciting research in progress at the present time concerns our attempt to match the antidepressant to the patient from the outset; we may be able to perform laboratory tests or identify clinical factors that let us know in advance which antidepressant will work for each person," Stotland said. "That will be an enormous advance for the millions of people suffering from this very painful and potentially disabling disease."

More information

To learn more about antidepressants, visit the U.S. National Library of Medicine.



SOURCES: American Psychiatric Association, news release, Feb. 26, 2008; PLoS Medicine, Feb. 25, 2008, online


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Weight Loss Surgery May Help Less Severely Obese
2. 10th Anniversary of Revolutionary Teaching Approach that Offers the Severely Disabled the Gift of Self-Expression - Through Painting
3. New Hope for Depressed Teens
4. Optimal band imaging with endoscopy facilitates the diagnosis of depressed-type early gastric cancer
5. Why some depressed girls cant smell the roses
6. Possible genetic predictor for response to lithium augmentation in depressed patients
7. Depressed Moms Kids at Higher Injury Risk
8. Drug Plus Psychotherapy Best Treatment for Depressed Teens
9. Kaiser Permanente Study Shows One in Seven Women are Depressed Before, During, or After Pregnancy
10. Treatment Programs Benefit Depressed Workers
11. Are too many people diagnosed as depressed?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Only Severely Depressed Benefit From Antidepressants: Study
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: ... develop to enable prevention of a major side effect of chemotherapy in children. ... pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a dose ...
(Date:10/12/2017)... PA (PRWEB) , ... October 12, 2017 , ... ... is the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B ... York City on October 11, 2017. , The annual award competition recognizes editorial and ...
(Date:10/12/2017)... ... ... On Saturday, October 21, the Health & Wellness Center at Florida Hospital ... for the American Heart Association Heart Walk. Teams of up to 10 people can ... their treadmills moving for 5 hours. Treadmills will start at 7:00 p.m. on Saturday, ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... first interactive health literacy software tool, and the Cancer Patient Education Network (CPEN), ... patient education, today announce a new strategic alliance. , As CPEN’s strategic ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief ... advancements to physician colleagues, skilled nursing facility medical directors and other clinicians at ... of Wound Care." , "At many of these conferences we get to educate ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
(Date:9/22/2017)... AVACEN Medical (AVACEN) announced that its CE-Marked ... those with the widespread pain associated with fibromyalgia in ... Essex, England commented, "I had ... no sleep at all, tremendous pain, with every movement ... [the AVACEN 100] enough, how this has and is ...
(Date:9/19/2017)... --  ZirMed Inc ., a recognized leader in cloud-based revenue ... been ranked #1 by its users for the seventh consecutive ... Survey. ZirMed was recognized as the top-ranked end-to-end revenue cycle ... over 200 beds and holds one of the longest #1 ... ...
Breaking Medicine Technology: