Navigation Links
Ongoing pregnancy rates from vitrified eggs as good as those from fresh
Date:6/30/2010

Rome, Italy: Embryos derived from oocytes (eggs) cryopreserved by the vitrification method are just as likely to produce an on-going pregnancy as those involving fresh oocytes, the 26th annual meeting of the European Society of Human Reproduction and Embryology heard today. Dr. Ana Cobo, Cryobiology Unit director at Institut Universitari IVI Valencia, Valencia, Spain, told delegates that the results of her team's research would make egg donation both easier and safer in the future.

The scientists carried out a randomised clinical trial involving 600 recipients of either freshly-harvested oocytes or those preserved by the vitrification method, where oocytes are flash-frozen after the extraction of water, hence avoiding ice formation. Analysis of the results found that the on-going pregnancy rate in women who had received vitrified oocytes was 43.7% as opposed to 41.7% in the fresh oocyte group. The proportion of top-quality embryos was similar between the two groups, and there was also no difference in age or other demographic characteristics and the incidence of male factor infertility.

"Because we were able to show that there were no differences between the two groups before embryo implantation," said Dr. Cobo, "we can be certain that the on-going pregnancy rates in both groups were not influenced by any factor other than the method of oocyte preservation. Although there has been considerable circumstantial evidence that cryopreservation by the vitrification method produces results as good as those with freshly-harvested oocytes, until this trial there was still a lack of large randomly-controlled studies in the field."

The researchers say that their results will have a significant effect on the practice of egg-banking in the future. "Many patients will be able to benefit," said Dr. Cobo. "For example, there are cancer patients who will be able to preserve their fertility before undergoing treatment that can make them sterile, patients who would be at risk of ovarian hyperstimulation, and those where a semen sample is not immediately available."

Once an egg donor is recruited and screened she undergoes ovarian stimulation to produce a number of oocytes, which are then retrieved. The oocytes then need to be fertilised by the sperm of the male partner of the recipient and the best embryos thus produced are placed in the uterus of the recipient, whose uterine lining has been previously prepared to be ready to receive the embryo.

When using fresh oocytes, the need for synchronisation of all these procedures is paramount, but not always possible. Egg banking precludes the need to synchronise these timings, which can also be the cause of long delays.

"As well as being able to shorten or even eliminate the current long waiting lists, egg banking also offers a safer donation process because it allows oocytes to be quarantined while the absence of any contagious disease in the donor is confirmed," said Dr. Cobo. "Until now we have been unable to do this with any certainty."

The scientists now intend to continue their research by following up the progress of babies born after oocyte vitrification. "We need to ascertain that there are no adverse effects on children conceived from cryopreserved oocytes," said Dr. Cobo, "so we will compare obstetric and neonatal data from babies born after oocyte vitrification with those resulting from the replacement of embryos originating from fresh oocytes. Having made sure that the pregnancies are safe, it is important to ensure that pregnancy outcomes are also free from harm."


'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
European Society of Human Reproduction and Embryology
Source:Eurekalert

Related medicine news :

1. Texas Health Care Association: Meeting Texas Seniors Ongoing Care Needs Threatened by Looming State, Federal Funding Threats
2. Carfilzomib Safety Data From Ongoing Phase 2b Pivotal Trial in Relapsed and Refractory Multiple Myeloma Show Promising Safety and Tolerability
3. One Month after Major Quake, Ongoing Crises for Haitian Children
4. Vaccine Not Fail-Safe in Ongoing Mumps Outbreak
5. Ongoing Toyota Recall Holds Serious Liability Implications For Manufacturer, but Consumers Must Be Protected, Says Texas Attorney Brad T. Wyly
6. Touching Souls International Giving Free Cataract Surgery and Eye Treatment in Bangladesh as Part of Ongoing Program June 6
7. UND Acquires ProtectionPlus in Ongoing Effort to Reduce Nuclear Stress Testing Costs for Physicians
8. Chinese-American and Korean-American women at highest risk for diabetes in pregnancy
9. Acupuncture found effective against depression during pregnancy
10. Care Net Calls Tebow Ad Opponents Slam of Pregnancy Centers Nonsensical
11. Stress, Anxiety Can Up Risk of Depression in Pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... States of America (PRWEB) , ... May 28, 2016 , ... ... SuperCloset knows all too well the day to day issues, struggles and obstacles ... military. The Helping Veterans Grow Project provides active or retired military veteran(s) with ...
(Date:5/28/2016)... ... May 28, 2016 , ... After a year and a half of planning the Multiple ... The Multiple Pathways of Recovery Conference was held May 2 -4, 2016 at the ... United Kingdom came together to explore the many pathways individuals use to get into and ...
(Date:5/27/2016)... ... ... Southland Log Homes , designer and manufacturer of America’s Favorite Log ... be found on its website at SouthlandLogHomes.com. , The designs of the wood ... craftsmanship of timber post and beam construction. The result is a barn that ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... An ... returns for a third time to shed lights on the variety of topics detailing ... inspirational stories, “Nurse Appreciation” tackles why this career has gone from being in a ...
(Date:5/27/2016)... ... May 27, 2016 , ... An educational ... by inspiring human-interest stories, courtesy of awareness-driven celebrities and thought leaders. It also ... advocates, associations and industry leaders such as Bioness. , As patients feel ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... 31, 2016 RnRMarketResearch.com adds "Asthma ... comparative analysis of Asthma therapy at various stages, therapeutics ... of administration (RoA) and molecule type, along with latest ... reviews key players involved in the therapeutic development for ... Complete report on H1 2016 pipeline review ...
(Date:5/30/2016)... 30, 2016 On 28 May, 194 ... by 2030. At the 69 th World Health Assembly, ... Hepatitis Strategy, signalling the greatest global commitment in viral hepatitis ... eliminating hepatitis B and C by 2030 and includes a ... reduce annual deaths by 65% and increase treatment to 80%, ...
(Date:5/27/2016)... LabStyle Innovations Corp . ( NASDAQ: DRIO ... that the Company,s Chief Financial Officer, Zvi Ben-David ... 1-2 in New York, NY and ... Los Angeles, CA. During his ... including the U.S. FDA Clearance and commercial launch of the ...
Breaking Medicine Technology: