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One-year results from Horizons-AMI trial reported at TCT 2009
Date:9/21/2009

2% vs. 4.0%), composite major adverse cardiovascular events (18.2% vs. 25.4%), and NACE (27.1% vs. 34.5%) rates with BIV therapy as compared with UFH + GPI, with no differences in ischemic TVR and stroke rates in the 2 groups.

The researchers concluded that in STEMI patients undergoing primary PCI, treatment with BIV compared to UFH + a GPI reduces major bleeding and 1-year mortality. Numerical reductions in major bleeding in BIV patients were present in all risk groups, whereas patients at high risk of mortality had the greatest survival advantage with BIV.

"While all risk categories of patients experienced a numerical decrease in 1-year mortality when randomized to bivalirudin, the relative reduction in mortality for those at highest risk of dying was nearly 50%, with an absolute reduction of 7.5%, suggesting that for every 100 high risk patients treated with bivalirudin rather than heparin plus a GPIIb/IIIa antagonist, seven more patients will be alive at one year after treatment," said Dr. Parodi. "Ongoing analyses are needed to determine if this mortality benefit in the patients at highest risk for death is due to a greater risk for, and reduction in bleeding in this cohort."


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Contact: Judy Romero
jromero@crf.org
347-407-2774
Cardiovascular Research Foundation
Source:Eurekalert

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