Navigation Links
One-year results from Horizons-AMI trial reported at TCT 2009
Date:9/21/2009

d the impact of bivalirudin versus unfractionated heparin (UFH) plus a glycoprotein IIb/IIIa inhibitor (GPI) on clinical outcomes in patients with STEMI undergoing primary PCI of the LAD.

In the international, large-scale prospective HORIZONS-AMI trial (Principal Investigator: Gregg Stone, MD), 3,602 patients were randomized to bivalirudin monotherapy vs. UFH+GPI. Of these, 1,445 patients underwent primary PCI of the LAD, whereas 1,884 patients underwent primary PCI of only non-LAD lesions. The occurrence of MACE (death, reinfarction, ischemic target vessel revascularization or stroke), major bleeding and net adverse clinical events (NACE = MACE or major bleeding) at 12 months were assessed in the two groups.

In comparing patients undergoing LAD versus non-LAD primary PCI, the rates of net adverse clinical events (19.3% vs. 15.4%), MACE (14.1% vs. 10.3%), death (5.6% vs. 2.8%) and cardiac death (4.2% vs. 1.9%) were significantly higher (all p<0.05) in LAD patients, whereas the rates of major bleeding (8.4% vs. 7.3%, p=0.27) and stent thrombosis (3.4% both) did not significantly differ.

Patients with LAD lesions were also randomized to treatment with bivalirudin (N=699) or UFH+GPI (N=746). The baseline clinical and angiographic features were well matched between these groups. "In patients treated with bivalirudin as compared to UFH+GPI, NACE (18.3% vs. 20.2%, p=0.31) and MACE (14.0% vs. 14.2%, p=0.90) did not significantly differ, whereas major bleeding (6.5% vs. 10.1%, p=0.01) and cardiac death (3.0% vs. 5.3%, p=0.04) were significantly lower in bivalirudin treated patients," said Dr. Whrle.

Patients undergoing primary PCI of LAD as compared to non-LAD lesions had significantly higher one-year rates of NACE, MACE, death and cardiac death. In patients undergoing PCI of LAD lesions, anticoagulation with bivalirudin monotherapy rather than unfractionated heparin + GPI resulted in significant lower rates of major bleeding and cardiac
'/>"/>

Contact: Judy Romero
jromero@crf.org
347-407-2774
Cardiovascular Research Foundation
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. 132 Members of Congress Urge One-Year Delay in Controversial Medicare Bidding Program for Home Medical Equipment
2. INVEGA(TM) Shows Favorable Long-Term Safety Profile in a One-Year Study of Patients With Schizophrenia
3. New type of sirolimus-eluting stent demonstrates superior results
4. Details Emerge About Approach, Results of First US Face Transplant
5. Instrumentation Laboratory Announces Passion & Results Award Winners
6. Bioniche Reports Fiscal 2009 Year-End Results
7. Results of Ongoing Testing Show Air Quality is Safe Near Schools in Beaver and Erie Counties in Pennsylvania
8. Pharmacyclics Reports Fourth Quarter and Fiscal 2009 Financial Results
9. PRO-DEX, INC. Announces Fiscal 2009 Fourth Quarter and Full-year Results
10. Immucor to Announce Fiscal First Quarter Financial Results on Thursday, October 1, 2009
11. Neogen Corporation Announces 1st Quarter Results Conference Call
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2015)... The report segments the European patient handling equipment ... accessory, and region. The medical beds segment accounted ... handling equipment market, by product. However, the nonmechanical ... highest CAGR in the forecast period. , ... On the basis of type of care, the ...
(Date:2/26/2015)... Thousands of people in local communities nationwide ... for the Muscular Dystrophy Association during the 2015 MDA ... that will help save and improve the lives of ... Walk events unite and rally communities to raise funds ... are compromised — including everyday abilities like walking, running, ...
(Date:2/26/2015)... Somerset, NJ (PRWEB) February 26, 2015 ... global provider of advanced delivery technologies and ... health products, has today announced several expanded ... network. The expansions have been implemented in ... clinical packaging, where the proportion of highly-potent ...
(Date:2/26/2015)... Plains, NJ (PRWEB) February 26, 2015 ... “NJ Top Dentist” for Dr. David Caggiano! , ... experience and interests. Combining his background in biomedical ... years of experience as a general dentist allows Dr. ... toughest orthodontic situations. He was named Orthodontic Products’ ...
(Date:2/26/2015)... Deerfield, IL (PRWEB) February 26, 2015 ... present during adolescence and young adulthood. In response ... age group, and in support of National Eating ... and Medicine (SAHM) presents new evidence-based recommendations for ... adolescents and young adults, including a new approach ...
Breaking Medicine News(10 mins):Health News:European Patient Handling Equipment Market Hit to $5,150.2 Million by 2019 - New Resaerch Report by MarketsanMarkets 2Health News:European Patient Handling Equipment Market Hit to $5,150.2 Million by 2019 - New Resaerch Report by MarketsanMarkets 3Health News:MDA Kicks-Off Annual Muscle Walk Season in Local Communities Nationwide to Fight Back Against Muscle Disease 2Health News:MDA Kicks-Off Annual Muscle Walk Season in Local Communities Nationwide to Fight Back Against Muscle Disease 3Health News:Catalent Expands European Clinical Packaging Capabilities, Highlighting Growing Industry Need for Specialty Handling 2Health News:Catalent Expands European Clinical Packaging Capabilities, Highlighting Growing Industry Need for Specialty Handling 3Health News:Dr. David Caggiano of Caggiano Orthodontics is Celebrating Five Years as an "NJ Top Dentist" ! 2Health News:Dr. David Caggiano of Caggiano Orthodontics is Celebrating Five Years as an "NJ Top Dentist" ! 3Health News:SAHM: Medical Providers Have Vital Lead Role in Diagnosing, Treating Restrictive Eating Disorders in Adolescents and Young Adults 2Health News:SAHM: Medical Providers Have Vital Lead Role in Diagnosing, Treating Restrictive Eating Disorders in Adolescents and Young Adults 3
... New Delhi: The National AIDS Control Organization (NACO) has ... to provide free anti-retroviral treatment (ART). //The count of ... on the anvil. , ,These centers will support ... the services of exclusive doctors, counselors and laboratory technicians ...
... or get the consent of one or both parents before ... to a Florida State University law professor in Tallahassee, Fla. ... and Thomas Stratmann, professor of economics at George Mason University, ... of gonorrhea among teenage girls as a measure of risky ...
... reduce their risk of becoming obese children, even if ... a study led by a researcher at the University ... ,The findings contradict an earlier, smaller study that found ... diabetes had poor glucose tolerance, a precursor to diabetes, ...
... self-image as the “strong, silent type” and the stigma ... less likely than women to be referred to studies ... recognize and express symptoms of depression, according to clinicians ... UC Davis Department of Psychiatry and Behavioral Sciences. ...
... tennis elbow and a wait and watch approach may be ... Australian researchers tested this approach in one group of volunteers, ... ,A second group were given a local ... The final group received eight treatments of physiotherapy of 30 ...
... amphetamine abuse in the Asia-Pacific region has hit high levels ... problem threatening Asia that is this big is a problem ... Australia as is the security of Australia in terms of ... the United Nations Office of Drugs and Crime told AFP. ...
Cached Medicine News:Health News:Abortion Notification, Consent Laws Reduce Risky Teen Sex 2Health News:Breast-Feeding May Reduce Childhood Obesity 2Health News:Stereotypes Contribute to Older Men Seeking, Receiving Depression Care Less Frequently 2Health News:Stereotypes Contribute to Older Men Seeking, Receiving Depression Care Less Frequently 3Health News:Stereotypes Contribute to Older Men Seeking, Receiving Depression Care Less Frequently 4Health News:Steroids Ineffective In Tennis Elbow 2
(Date:2/26/2015)... Feb. 26, 2015 Surna Inc. (OTCQB: ... in commercial indoor cannabis cultivation technology, announced today ... start-up to fast-paced manufacturing and engineering company. ... current Director and CEO, will be stepping down ... of what the team has accomplished thus far ...
(Date:2/26/2015)... N.Y. , Feb. 26, 2015 ... year at the Clearwater Beach Hilton to provide ... technology to plant reliability professionals from around the ... a stellar collection of leaders in the field ... the demand for excellence continues with this year,s ...
(Date:2/26/2015)... -- Medtronic, Inc. (U.S.), St. Jude Medical, Inc. ... the Saudi Arabia , South ... to lead the market during the period of 2014 to ... in the market, and owns a wide product portfolio including ... Neurostimulator are some of the most popular brands of the ...
Breaking Medicine Technology:Surna, Inc. Announces Senior Leadership Changes 2Surna, Inc. Announces Senior Leadership Changes 3Surna, Inc. Announces Senior Leadership Changes 4UE Systems Renowned "Ultrasound World" Conference Celebrates its 11th Year 2Middle East & Africa Internal Neurostimulation/Neuromodulation Market is Expected to Reach $6.1 Million by 2019, at a CAGR of 17.9% from 2014 to 2019 2Middle East & Africa Internal Neurostimulation/Neuromodulation Market is Expected to Reach $6.1 Million by 2019, at a CAGR of 17.9% from 2014 to 2019 3Middle East & Africa Internal Neurostimulation/Neuromodulation Market is Expected to Reach $6.1 Million by 2019, at a CAGR of 17.9% from 2014 to 2019 4
... 6, 2011 Actavis, an international generic pharmaceuticals ... approval from the US Food & Drug Administration ... mg CIV.  Distribution of the product has commenced. ... to launch Zolpidem Tartrate Extended-Release Tablets 6.25 mg strength ...
... June 6, 2011 Brainlab announced today ... acquire Voyant Health. Voyant Health,s core technology, ... and to plan and digitally template surgical procedures from ... the operating room (OR). Another key technology is VoyantLink™, ...
Cached Medicine Technology:Actavis Receives FDA Approval of Zolpidem Tartrate Extended-Release Tablets USP, 12.5 mg CIV in the U.S. 2Brainlab Acquires Voyant Health 2Brainlab Acquires Voyant Health 3
Bone Currettes...
Kevorkian Endocervical Curette is a stainless-steel curette with a basket. It is narrow tipped for sampling without dilation....
...
...
Medicine Products: