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One-year results from Horizons-AMI trial reported at TCT 2009
Date:9/21/2009

SAN FRANCISCO, CA SEPTEMBER 21, 2009 Two subset analyses from the landmark HORIZONS-AMI trial show that the anticoagulant bivalirudin lowers major bleeding and cardiac death versus the combination of heparin and a GP IIb/IIIa inhibitor in patients with ST-segment myocardial infarction (STEMI) who have disease of the left anterior descending artery (LAD), while in STEMI patients at highest risk for death, bivalirudin also confers the greatest mortality benefit.

Two teams of European researchers will report on one-year results from these two substudies at the 21st annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation (CRF). Both will be presented as poster abstracts (TCT-306 and TCT-304) on Tuesday, September 22 between 8:00 a.m. and 10:00 a.m. in Hall D of The Moscone Center.

The landmark HORIZONS-AMI trial, sponsored by CRF, is expected to significantly impact the way that patients are treated. Two-year data from the trial will also be presented as a Late Breaking Trial on Friday, September 25 at TCT.

The two abstracts examine additional important information regarding outcomes of patients with acute myocardial infarction (AMI). One of the substudies focuses on primary angioplasty in acute anterior myocardial infarction with bivalirudin compared to unfractionated heparin plus GpIIb/IIIa inhibitors. This includes patients with massive heart attacks and the effect of pharmacotherapy in these patients. The other substudy examines the benefits of bivalirudin therapy in the highest risk patients who present with a heart attack.

A research team lead by Jochen Whrle, MD, University of Ulm (Ulm, Germany) looked at clinical outcomes in patients with ST segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) of left anterior descending (LAD) coronary artery disease compared to non-LAD lesions. Investigators evaluate
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Contact: Judy Romero
jromero@crf.org
347-407-2774
Cardiovascular Research Foundation
Source:Eurekalert

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