Navigation Links
One route to malaria drug resistance found
Date:7/24/2014

nce isoprenoids are necessary for life, it's not clear why the organism would purposefully slow down isoprenoid production.

"We don't know why the protein puts the brakes on under normal conditions," Odom said. "Perhaps simply because it's an energetically expensive pathway. But loss of PfHAD1 releases the brakes, increasing the pathway's activity, so that even when the drug is there, it doesn't kill the cells."

Odom says isoprenoid synthesis is an attractive drug target not just for malaria but for tuberculosis and other bacterial infections because these organisms also rely on this same isoprenoid pathway. While people make isoprenoids, these vital compounds are manufactured entirely differently in animals compared with many infectious pathogens likely to cause disease.

Inhibiting isoprenoid manufacturing in malaria, bacteria or tuberculosis, for example, would in theory leave the human pathways safely alone. In people, perhaps the most well-known isoprenoid is cholesterol, with statin drugs famously inhibiting that manufacturing pathway.

Odom, who treats patients at St. Louis Children's Hospital, said she sees a handful of malaria cases each year, mostly in patients who have recently traveled to parts of the world where malaria is common. The parasite remains a massive global health problem, causing about 627,000 deaths in 2012 alone, according to the World Health Organization. Most deaths are in children under age 5.

Despite this public health burden, malaria is understudied in the lab because it is notoriously difficult to grow. It has a complex lifecycle that includes two-way transfers between mosquito and human and spans different forms in the human liver and red blood cells.

"The malaria parasite is difficult to work with in the lab; it's nearly impossible to replicate the lifecycle," Odom said. "That's why it was so exciting to be able to do this kind of study in malaria, rather than in a typical mode
'/>"/>

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Novel drug candidates offer new route to controlling inflammation
2. Doubling down on heart failure: Researchers discover new route to disease, and drugs to match
3. New roadmap suggests proven routes to ending health disparities
4. A new route for tackling treatment-resistant prostate cancer
5. Auto-immune disease: The viral route is confirmed
6. Federal Safe Routes to School program reduces child injuries by more than 40 percent in New York City
7. Employee Wellness Challenge Get Fit on Route 66 Has New Mobile App, Announces Health Enhancement Systems
8. A circuitous route to therapy resistance
9. Patheon to Host Complimentary Seminar on “Robustness, Reproducibility and Risk Management; the Route to Successful Commercialisation” at Patheon Bourgoin-Jallieu site
10. Jekyll-and-Hyde protein offers a new route to cancer drugs
11. UNC child neurologist finds potential route to better treatments for Fragile X, autism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
One route to malaria drug resistance found
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... AGA Medical Corporation announced,today that it received European ... (ACP). The ACP provides an innovative, minimally,invasive solution for ... intended use will be for the non-surgical occlusion of ... "The ACP is an important addition to the ...
... Scientists at UT Southwestern Medical Center have determined that the ... immune system how to fight off repeated infections of the ... Dec. 15 issue of the Journal of Immunology , ... and anti-viral therapies. , Typically, when a person is ...
... helped,explain how our brains build meaningful images from the bits ... Louisville Grawemeyer Award for Psychology. , Anne ... Princeton University , was selected for the ninth Grawemeyer,psychology ... Treisman, a cognitive psychologist, proposed in 1980 that ...
... immigrants in Oslo. Compared with Norwegians, the differences are also ... diseases. This is shown in a new report from the ... groups were compared with each other and the ethnic Norwegian ... care better. , The five immigrant groups in this ...
... The statistics for sexual assault are unsettling; the Department ... will be the victim of attempted or actual sexual ... researchers from two universities, including the University of Missouri, ... drug-facilitated sexual assault and fail to recognize the risk ...
... Center ranks No. 1 nationwide for the speed with which heart ... Cardiovascular Data Registry (NCDR). , ... (Vocus) December 2, ... speed with which heart attack patients are treated using balloon angioplasty, ...
Cached Medicine News:Health News:AGA Medical Receives European CE Mark Approval for AMPLATZER(R) Cardiac Plug 2Health News:Interferon needed for cells to 'remember' how to defeat a virus, UT Southwestern researchers report 2Health News:Theory of How Brain Builds Images Earns Grawemeyer Prize 2Health News:Large health differences between population groups in Norway 2Health News:Large health differences between population groups in Norway 3Health News:Large health differences between population groups in Norway 4Health News:MU researcher calls for increase in sexual assault awareness programs on college campuses 2Health News:MU researcher calls for increase in sexual assault awareness programs on college campuses 3Health News:UCSF Medical Center Leads Nation in ER Heart Attack Care 2Health News:UCSF Medical Center Leads Nation in ER Heart Attack Care 3
(Date:12/24/2014)... FARMINGTON, Conn. , Dec. 24, 2014 ... a biopharmaceutical company developing targeted, receptor-specific peptide therapeutics ... medical need and commercial potential, today announced that ... 2,050,000 shares of its common stock and Series ... common stock.  Funds under the management of QVT ...
(Date:12/24/2014)... , Dec. 23, 2014  Advanced Medical ... company engaged primarily in the development of brachytherapy ... applications, today announced that it has filed a ... and Drug Administration ("FDA") for marketing clearance for ... 513(f)(2) of the U.S. Food, Drug and Cosmetic ...
(Date:12/24/2014)... 23, 2014   Assurex Health, a personalized ... healthcare providers for behavioral health and chronic pain ... million in equity financing from new and existing ... President and Chief Executive Officer. The ... of Assurex Health,s GeneSight ®  products.  ...
Breaking Medicine Technology:Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4
... 2011 Savvy executives in pharmaceutical commercial functions ... in today,s volatile healthcare environment. Quantitative and qualitative ... for increased resources, justify costs, or signal necessary ... presidents, directors, and managers tasked with right-sizing investment ...
... Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in the ... European Medicines Agency (EMA) has granted orphan designation for ... B. Orphan designation in the European Union provides several ... launch and access to the central authorization procedure. ...
Cached Medicine Technology:Pharmaceutical Investment & Cost Benchmarks Accessed Quickly Through Best Practices, LLC's New Database Search Function 2Amsterdam Molecular Therapeutics Receives Orphan Designation in the European Union for Hemophilia B Gene Therapy 2
... Dehydroepiandrosterone (DHEA) is produced in the adrenal ... gonads [1,2,3]. DHEA serves as a precursor ... relatively weak androgenic activity, estimated at ~10% ... peripubertal children and in adult women, DHEA ...
... testosterone exists as unbound or free testosterone. ... SHBG with high affinity [1], while the ... the albumin-bound and free fractions may be ... action. Measurement of the free or unbound ...
... primary active hormone synthesized within the follicular ... is synthesized via a series of steps ... cells, (ii) iodination of tyrosine residues in ... 3-monoiodotyrosine and 3,5-diiodotyrosine (MIT and DIT), and ...
... protein-3 (IGFBP-3) is the main binding protein for ... component of the ~150 kDa ternary complex. This ... or IGF-II and ALS, allowing IGFBP-3, along with ... The molar concentration of IGFBP-3 in normal serum ...
Medicine Products: