Navigation Links
One route to malaria drug resistance found
Date:7/24/2014

Researchers have uncovered a way the malaria parasite becomes resistant to an investigational drug. The discovery, at Washington University School of Medicine in St. Louis, also is relevant for other infectious diseases including bacterial infections and tuberculosis.

The study appears July 24 in Nature Communications.

Many organisms, including the parasite that causes malaria, make a class of molecules called isoprenoids, which play multiple roles in keeping organisms healthy, whether plants, animals or bacteria. In malaria, the investigational drug fosmidomycin blocks isoprenoid synthesis, killing the parasite. But over time the drug often becomes less effective.

"In trials testing fosmidomycin, the malaria parasite returned in more than half the children by the end of the study," said senior author Audrey R. Odom, MD, PhD, assistant professor of pediatrics. "We wanted to know how the parasite is getting around the drug. How can it manage to live even though the drug is suppressing these compounds that are necessary for life?"

Fosmidomycin, an antibiotic, is being evaluated against malaria in phase 3 clinical trials in combination with other antimalarial drugs.

Using next-generation sequencing technology, the research team compared the genetics of malaria parasites that responded to the drug to the genetics of malaria parasites that were resistant to it. With this approach, Odom and her colleagues found mutations in a gene called PfHAD1. With dysfunctional PfHAD1, malaria is resistant to fosmidomycin.

"The PfHAD1 protein is completely unstudied," Odom said. "It's a member of a larger family of proteins, and there are almost no biological functions assigned to them."

In malaria parasites, Odom's team showed that the PfHAD1 protein normally slows down the synthesis of isoprenoids. In other words, when present, PfHAD1 is doing the same job as the drug, slowing isoprenoid manufacturing. Si
'/>"/>

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Novel drug candidates offer new route to controlling inflammation
2. Doubling down on heart failure: Researchers discover new route to disease, and drugs to match
3. New roadmap suggests proven routes to ending health disparities
4. A new route for tackling treatment-resistant prostate cancer
5. Auto-immune disease: The viral route is confirmed
6. Federal Safe Routes to School program reduces child injuries by more than 40 percent in New York City
7. Employee Wellness Challenge Get Fit on Route 66 Has New Mobile App, Announces Health Enhancement Systems
8. A circuitous route to therapy resistance
9. Patheon to Host Complimentary Seminar on “Robustness, Reproducibility and Risk Management; the Route to Successful Commercialisation” at Patheon Bourgoin-Jallieu site
10. Jekyll-and-Hyde protein offers a new route to cancer drugs
11. UNC child neurologist finds potential route to better treatments for Fragile X, autism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
One route to malaria drug resistance found
(Date:10/20/2014)... Principle Business Enterprises, a family owned ... top-of-the-line absorbent products. The company has recently made ... brand, Tranquility® Premium Protection absorbent products. The company ... its packaging a new look, and is currently working ... the public. , The new website, developed with Thread ...
(Date:10/20/2014)... PA (PRWEB) October 20, 2014 ... Matthew Voicheck as Assistant Director of their ... role in managing the innovative turnkey drug sourcing, ... , Matthew brings over 12 years of industry ... joins Myoderm at the peak of their international ...
(Date:10/20/2014)... Succeed is proud to announce that they ranked ... the Every Body Walk! campaign by Kaiser Permanente. ... encourages workers to be more active outside of the workplace. ... at the end of September, was a friendly competition between ... Participating companies gave their staff pedometers and each day, ...
(Date:10/20/2014)... 2014 National Teen Driver Safety Week is ... Academy of Pediatrics (Ohio AAP, http://www.ohioaap.org ) is joining ... of teen drivers to talk to their teens and always ... vehicle crashes are the leading cause of death for U.S. ... fatal crashes, and 859 (42%) of those teen drivers were ...
(Date:10/20/2014)... Unveiled at the Sept. 18 board meeting, The Center ... hospital ROI on membership dues at 12.5. In other words, ... in value to member hospitals. The calculation used to determine ... , “This is the first time we’ve actually been ... methodology is really sound,” said Bill Ryan , president ...
Breaking Medicine News(10 mins):Health News:Tranquility® Premium Protection Incontinence Products Releases New Logo and Website 2Health News:Myoderm Hires Matthew Voicheck to Lead Turnkey Drug Sourcing Service 2Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2Health News:Ohio AAP Promotes National Teen Driver Safety Week 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 4
... River Valley Water Supply Project's key agenda is to transfer ... heavily populated areas in the red river drainage basin. // ... proposition, due to a perceptible risk of foreign biota filling ... of the Earth Canada, feels that a task of such ...
... pneumonia, bronchitis and other infections. Bristol-Myers Squibb Co. (BMY) ... Food and Drug Administration said that the drug would ... blood-sugar changes due to this drug. ,This ... serious cases of hypoglycemia (low blood sugar) and hyperglycemia ...
... Ranbaxy has introduced a diagnostic test for Bird Flu that ... accurate results within 24 hours. Named as RT-PCR test, // ... be available in a day. Certainly a blessing in the ... available to check for Bird Flu report results only after ...
... of dance lovers in discos has been found to work ... was first synthesised in 1910. It was patented two years ... suppressant. ,The study finds that loud music exacerbates ... was conducted by Italian scientists on rats. Who were given ...
... on either couple, men seem to be more vulnerable, according ... his research team from Harvard Medical School. ,The ... the risk of illness in the other partner in a ... ,They found that when a spouse was hospitalized, ...
... Medicines Racket is growing at alarming proportions. The United Nations ... wide initiative , by way of a task force team ... of counterfeit drugs. A three day meeting is underway in ... - Pharamaceutical companies, Regulatory bodies and groups which represent the ...
Cached Medicine News:Health News:The effects of Ecstasy more pronounced in presence of music 2
(Date:10/20/2014)... -- Indianapolis interventional medical device maker NICO Corporation ... visualization leader Synaptive Medical announced today ... that they have joined forces to integrate their ... the first of its kind and will make ... BrainPath® interventional access technology and Synaptive,s BrightMatter™ real-time ...
(Date:10/20/2014)...  AnaptysBio, Inc., a leader in the discovery ... appointment of Marco Londei , M.D. as ... preclinical and clinical development of AnaptysBio,s proprietary antibody ... welcome Dr. Londei to AnaptysBio,s executive leadership team," ... Executive Officer of AnaptysBio. "Dr. Londei,s extensive expertise ...
(Date:10/20/2014)... -- Norgine B.V. today announced that the ... preparation, NER1006, presented at the 79 th Annual ... Philadelphia, PA , has met its ... endpoint of cleansing success. The study demonstrated high quality ... in screening colonoscopy patients. [1] (Logo: ...
Breaking Medicine Technology:Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 2Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 3Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 4Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 5AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2Positive Results from Phase II Data Show NER1006 Achieves High Quality Bowel Cleansing Efficacy 2
... 2011 The Radiosurgery Society™ (RSS), a non-profit organization ... clinical practice of stereotactic body radiotherapy (SBRT) and radiosurgery ... at the La Costa Resort in Carlsbad, Calif.   ... Radiosurgery Society has been expanded to serve as a ...
... To reward loyal shoppers, CVS/pharmacy today ... multiple free gift cards just by shopping for essentials ... began on Sunday October 16 and will go through ... can earn $10 gift cards to Macy,s, Gap, Applebee,s, ...
Cached Medicine Technology:Announcing The Radiosurgery Society™ And Its 2012 SRS/SBRT Scientific Meeting 2Announcing The Radiosurgery Society™ And Its 2012 SRS/SBRT Scientific Meeting 3Save Big This Fall with CVS/pharmacy's Free Gift Cards Promotion 2Save Big This Fall with CVS/pharmacy's Free Gift Cards Promotion 3
Straight 9 mm downcutting Royce blade. Can be placed in closed handle for protection. Handle length folded 109 mm, 4.3 inches. Blade can be set automatically and rigidly at any point from straight to...
Duckbill. 3.5 mm tip. Light curve....
Duckbill type, sharp. 3 mm x 8 mm curved blade. Octagonal handle....
4 mm x 9 mm tip....
Medicine Products: