Navigation Links
One for you, one for me
Date:11/17/2011

KANSAS CITY, MO -- Each time a cell divides -- and it takes millions of cell divisions to create a fully grown human body from a single fertilized cell -- its chromosomes have to be accurately divvied up between both daughter cells. Researchers at the Stowers Institute for Medical Research used, ironically enough, the single-celled organism Saccharomyces cerevisiae -- commonly known as baker's yeast -- to gain new insight into the process by which chromosomes are physically segregated during cell division.

In a study published in the Nov. 17, 2011 issue of PLoS Genetics, they demonstrate that a protein known as Mps3 not only ensures that cells have two functional spindle pole bodies, which generate the mitotic spindle apparatus that helps pull the chromosomes apart, but also that both spindle pole bodies are properly anchored in the nuclear membrane.

"When you enter mitosis, you need to have two spindle pole bodies on which you can pull the chromosomes. If you don't, the probability of errors in chromosome segregation increases exponentially," explains Jaspersen, adding that, "even small mistakes can lead to birth defects, genetic instability and cancer."

Normally, cells have only a single spindle pole body, but in preparation for cell division, the spindle pole body has to duplicate itself just as the genome does. "We know a whole lot about how DNA copies itself, but we don't know much about how spindle pole bodies duplicate themselves," says Jaspersen.

Unlike DNA molecules, which serve as templates for the production of identical copies, the spindle pole body is a large protein structure composed of soluble proteins and so-called integral membrane proteins, which are anchored in the nuclear envelope. The duplication process of the lone spindle pole body begins when soluble proteins coalesce on the nuclear envelope followed by their insertion into the lipid bi-layer located next to the original spindle pole body. Insertion p
'/>"/>

Contact: Gina Kirchweger
gxk@stowers.org
816-806-1036
Stowers Institute for Medical Research
Source:Eurekalert  

Page: 1 2 3

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
One for you, one for me
(Date:5/25/2015)... 2015 Decora Preset 60 Minute Countdown ... available on ‘The Hardware City.’ The product helps in automatically ... a time and the related electronic device is automatically turned ... of the company said, “We are glad that this amazing ... can buy Countdown Timer Switch in just a few clicks. ...
(Date:5/24/2015)... Metamora, Michigan (PRWEB) May 24, 2015 ... for concerns about hair loss. Although it is unclear ... that there are environmental factors such as metabolism, nutritional ... contribute. Since they offer a comprehensive approach to evaluating ... and post-menopausal woman, they can help patients find a ...
(Date:5/24/2015)... Scientists with Cardno ChemRisk, a scientific consulting firm, ... that may have raised the risk of mesothelioma for ... an article on the research. Click here to ... asbestos levels well above OSHA safety guidelines when they ... “Asbestos compliance sampling data associated with the construction, automotive ...
(Date:5/24/2015)... ProPin is a set of self-animating 3D pin markers ... to pin point locations on a map, to indicate prices or ... users to choose from 30 simplistic presets with geometric design elements ... editors can easily manipulate ProPin presets as a whole. Pixel ... , Using ProPin is easy, simply drag a preset into the ...
(Date:5/24/2015)... Geneva, WI (PRWEB) May 24, 2015 ... Mercy Health System CEO - ... principal and honored at the fourth ... held April 15 at Geneva National ... (by school): ,     -Badger High School, ...
Breaking Medicine News(10 mins):Health News:Leviton's Decora 60 Minute Countdown Timer Available On ‘The Hardware City’ 2Health News:Women's Excellence Now Treats Menopausal Hair Loss 2Health News:New Analysis Finds Too Many Employers Ignored OSHA Asbestos Guidelines, According to Surviving Mesothelioma 2Health News:Developers at Pixel Film Studios Release ProPin for Final Cut Pro X. 2Health News:Mercy Foundation Honors 16 Students for Making a Difference - Mercy Health System Javon Bea 2
... Pass Bill Includes New Radio Ads Airing Today ... bill to repeal the broken Medicare physician payment formula that ... dimension to its Medicare campaign today with radio ads airing ... ads, the AMA is activating its nationwide grassroots network of ...
... may realize that they have a significant chance of needing ... care, believe government programs cover more than they actually do, ... potential care. A national survey of 935 people ages 21 ... (November) and John Hancock,s "Know Your Options" campaign, found that ...
... still recommended in the first trimester, researchers say , FRIDAY, ... take folic acid in late pregnancy are at increased risk ... study included more than 500 women whose diet and supplements ... asthma at age 3.5 years and at 5.5 years. Asthma ...
... researchers fear , FRIDAY, Nov. 13 (HealthDay News) -- ... 60s with far more physical disabilities than previous generations, ... system. , That,s the finding of University of California, ... and 1999 National Health and Nutrition Examination Surveys to ...
... cancer cells is that they are similar in many respects ... researchers at Karolinska Institutet have found a new way of ... journal Cell . Molecular signal pathways that stimulate ... those active in tumour growth. This limits the possibility of ...
... ... cooperation with PhRMA, will host a workshop on Dried Blood Spot Sampling in the Pharmaceutical ... , ... 13, 2009 -- The Drug Information Association (DIA) , in cooperation with PhRMA, will ...
Cached Medicine News:Health News:AMA Calls on Congress to Pass H.R. 3961, Access to Care for Seniors and Military Families at Stake 2Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 2Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 3Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 4Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 5Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 6Health News:Folic Acid Late in Pregnancy Tied to Asthma in Kids 2Health News:Baby Boomers May Prove More Disabled Than Their Elders 2Health News:Paradoxical protein might prevent cancer 2Health News:,DIA/PhRMA Workshop to Explore Dried Blood Spot Sampling Implementation and Advances, 2Health News:,DIA/PhRMA Workshop to Explore Dried Blood Spot Sampling Implementation and Advances, 3
(Date:5/22/2015)... R.I. , May 22, 2015 ... once-daily central nervous system stimulant indicated for the ... to patients beginning Summer 2015. ... XR received approval from the U.S. Food and ... is an extended-release formulation of methylphenidate capsule with ...
(Date:5/22/2015)... May 22, 2015 AcelRx Pharmaceuticals, Inc. (Nasdaq: ... the development and commercialization of innovative therapies for the ... interim chief executive officer Howie Rosen will ... financial officer Tim Morris will be presenting ... two presentations are as follows: Jefferies 2015 ...
(Date:5/21/2015)... , May 21, 2015  When Ryan ... the side of his neck, he figured ... a couple weeks off from weight lifting. ... away.                               A series ... was referred to Michel Kliot, MD ...
Breaking Medicine Technology:Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 2Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 3Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 4Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 5Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 6AcelRx Pharmaceuticals to Present at Two Upcoming Investor Conferences In June 2Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 2Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 3Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 4
... Medical Systems, Inc. (NYSE: VAR ), the world,s ... and radiosurgery, is introducing its new TrueBeam™ medical linear accelerator ... 10th annual meeting of the Asia-Oceania Congress of Medical Physics ... The TrueBeam system, which was designed from the ground up ...
... -- China Sky One Medical, Inc. ("China Sky One ... a leading fully integrated pharmaceutical company producing over-the-counter drugs ... that it held its 2010 Annual Meeting of Stockholders ... PRC.   At the Annual Meeting, the ...
Cached Medicine Technology:Varian Medical Systems Introduces New TrueBeam™ System for Image-Guided Radiotherapy and Radiosurgery to Clinicians in Asia at AOCMP in Taipei, Taiwan 2China Sky One Medical, Inc. Reports Outcome of Annual Meeting of Shareholders 2
Angled insertion forcep used for the Hydroview lens. Manufactured in titanium....
Titanium. Curved 18 mm shafts with 1.5 wide grasping tip. Flat, serrated cross action handle with dull finish....
30 degree angled tip with 45 mm tip opening. Made with lock. Manufactured in titanium....
Straight 25 gauge shaft with angled tip and sliding inner shaft. Shaft holds the proximal loop against the angled tip while handle in the normal state. Squeeze type handle with dull finish....
Medicine Products: