Navigation Links
One cell type may quash tumor vaccines
Date:4/28/2014

elper cells, they were able to see a vigorous activation of cytotoxic T cells and B cells directed at GUCY2C.

In fact, the GUCY2C vaccine-S1 combo improved the survival time of mice with cancer by months compared to only days with GUCY2C vaccine alone. In fact, many mice were cured of their disease.

When Dr. Snook tested two other cancer peptides, one for breast cancer (Her2) and one for melanoma (Trp2), he saw similar results, suggesting that selective inactivation of T helper cells occurs for peptides found in many cancer types. "The results make a lot of sense," says Dr. Snook. "T-helper cells, as their name suggests, provide help to both cytotoxic T cells and to B cells. The entire peptide-specific immune response can be taken out by tolerizing this one cell type."

In addition, T-helper cells are also essential for creating immunological memory. Boosting T-helper cell activation also protected mice from challenge with cancer months after the initial vaccination, increasing their survival and decreasing tumor number.

The next step is to test whether a T helper peptide-linked GUCY2C vaccine could help fight colorectal cancer in humans. Dr. Snook and colleagues are currently enrolling patients in a clinical trial aimed at reducing the rate of cancer recurrence in patients who had their primary tumors removed.


'/>"/>

Contact: Edyta Zielinska
edyta.zielinska@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers generate immunity against tumor vessel protein
2. 3D printing cancer tumors
3. Surprising new insights into the PTEN tumor suppressor gene
4. Finnish team of researchers finds a mutation in a tumor of the jaw
5. Scientists find key steps linking dietary fats and colon cancer tumor growth
6. Deep, integrated genomic analysis re-classifies lower-grade brain tumors
7. Prognosis of tumors positive for human papilloma virus in head and neck cancers varies according to the site
8. Adult cancer drugs show promise against an aggressive childhood brain tumor
9. New view of tumors evolution
10. Several FDA-approved anti-cancer drugs induce stem cell tumors, perhaps thwarting therapy
11. Going viral to target tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... Torrance Orthopaedics and Sports Medicine Group Dr. Nicholas ... of Affordable Medical Imaging Systems., REDONDO BEACH, ... of medical imaging systems to healthcare providers,today announced ... their,distinguished board of directors., Dr. Halikis joins ...
... in response to evidence-based recommendations ... drug labels, PHILADELPHIA, Nov. 28 You have just ... label says: "take one,tablet by mouth twice daily for 7 ... This might be easy for you to answer, but 46 ...
... genX International, Inc and,IVFonline, LLC (genX ... products are being sold to some IVF ... distributed by genX International,and IVFonline. Therefore, genX ... Coda(R) products and genX International cannot,guarantee that ...
... researchers at the University of Illinois have uncovered a host ... age, ranging from better brain function to improved immune responses. ... yet another benefit: a link between moderate exercise and decreased ... the study is that moderate exercise sped up how fast ...
... Researchers at the National Institute of Aging and Stanford University ... with age in 16 different mouse tissues. The study, ... database called AGEMAP to document the process of aging in ... aging affects different tissues in mice, and ultimately could help ...
... they could protect against type 2 diabetes , WEDNESDAY, ... treating diseases such as type 2 diabetes show promise, ... a gene controlling the aging process, the researchers report ... , In obese mice, these compounds improved insulin sensitivity, ...
Cached Medicine News:Health News:Prominent Orthopaedic Hand and Upper Extremity Surgeon Joins Radlink Board of Directors 2Health News:System of Simplified, Standardized Dosing Instructions for Prescription Medication Container Labels Proposed at Sixth Annual National Health Communication Conference 2Health News:System of Simplified, Standardized Dosing Instructions for Prescription Medication Container Labels Proposed at Sixth Annual National Health Communication Conference 3Health News:Warning - Beware of Counterfeit Coda(R) Products 2Health News:Exercise may play role in reducing inflammation in damaged skin tissue 2Health News:Exercise may play role in reducing inflammation in damaged skin tissue 3Health News:Exercise may play role in reducing inflammation in damaged skin tissue 4Health News:A molecular map for aging in mice 2
(Date:12/24/2014)... PRINCETON, N.J. , Dec. 24, 2014 /PRNewswire/ ... Company), a late-stage biopharmaceutical company developing products that ... inflammation, oncology and biodefense, announced today that on ... registered public offering. The Company raised ... offering and intends to use the net proceeds ...
(Date:12/24/2014)... , Dec. 24, 2014  Diplomat Pharmacy, Inc. (NYSE: ... pharmacy, is proud to announce Jennifer Hagerman , ... Diplomat, will take office as the president of the ... induction ceremony will take place Feb. 28, 2015, at ... held at the Renaissance Center in Detroit, ...
(Date:12/24/2014)... 23, 2014 PuraMed BioScience®, Inc., (OTC Pink: ... medicinal and healthcare products, announced it received the initial ... hemp-based, advanced headache relief product, for planned distribution to ... Colorado , Washington State , ... the MigraPure H Advanced headache relief gel formulation completed, ...
Breaking Medicine Technology:Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3
... Survey Underscores Impact of Disease on Work Status ... today at Digestive Disease Week(R) 2007 (DDW), from,long-term ... 1,& 2) show that subjects with moderately to ... REMICADE(R),(infliximab) in the blinded phase of the trials ...
... 2007 - Synta,Pharmaceuticals Corp., (NASDAQ: SNTA) a ... small,molecule drugs to treat severe medical conditions, ... the Phase 2b clinical,trial in metastatic melanoma ... will be presented at the annual meeting ...
Cached Medicine Technology:Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 2Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 3Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 4Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 5Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 6Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 7Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 8Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 9Synta Oncology Candidate STA-4783 Clinical Trial Results to Be,Presented at the ASCO Annual Meeting 2Synta Oncology Candidate STA-4783 Clinical Trial Results to Be,Presented at the ASCO Annual Meeting 3
... Lyoplant is a new biological ... A pure collagen implant, lyoplant ... three months, replacing implant material ... Its natural structure minimizes suture ...
The Bovie IDS Series are the latest electrosurgical generators with fully digital implementation....
Aaron 1250 is a multipurpose electrosurgical generator with monopolar and bi-polar functions....
European bipolar foot activated forceps....
Medicine Products: