Navigation Links
One cell type may quash tumor vaccines
Date:4/28/2014

(PHILADELPHIA) -- Most cancer vaccines have not lived up to their promise in clinical trials. The reason, many researchers suspect, is that the immune cells that would help the body destroy the tumor even those reactions boosted by cancer vaccines are actively suppressed. Now, researchers at Thomas Jefferson University have found that a single cell type is actively suppressed in several experimental cancer vaccines, paving the way toward methods to break suppression and improve the effectiveness of cancer vaccines. The work was published this week online in the European Journal of Immunology.

"The conventional wisdom is that the body knocks out all of the cells that can mount an immune response to the cancer," says first author Adam Snook, PhD, a Research Instructor at Thomas Jefferson University. "In fact, our work shows that it's only one cell type that is affected. But that cell, the T-helper cell, acts as the lynchpin."

Cancer vaccines are designed to boost the body's natural defenses against cancer. They work by training the immune system to recognize and attack specific tumor peptides, which are a kind of identification tag for tumors. These peptide "tags" help the immune system find and attack cancer cells. There are three types of cells that can "see" and react to these tags: T-helper cells, cytotoxic T cells, and B cells, and researchers thought that all three were trained, or tolerized, to ignore the tags on cancer cells.

Dr. Snook and colleagues tested which cell was involved by inoculating mice with a cancer vaccine they developed for colorectal cancer using a tumor peptide called guanylyl cyclase C (GUCY2C). Normally, GUCY2C-vaccinated mice would not produce much of an immune response, from either T cell type or B cells. However, when the researchers boosted the GUCY2C vaccine by linking it to another peptide called S1 that efficiently activates T-h
'/>"/>

Contact: Edyta Zielinska
edyta.zielinska@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers generate immunity against tumor vessel protein
2. 3D printing cancer tumors
3. Surprising new insights into the PTEN tumor suppressor gene
4. Finnish team of researchers finds a mutation in a tumor of the jaw
5. Scientists find key steps linking dietary fats and colon cancer tumor growth
6. Deep, integrated genomic analysis re-classifies lower-grade brain tumors
7. Prognosis of tumors positive for human papilloma virus in head and neck cancers varies according to the site
8. Adult cancer drugs show promise against an aggressive childhood brain tumor
9. New view of tumors evolution
10. Several FDA-approved anti-cancer drugs induce stem cell tumors, perhaps thwarting therapy
11. Going viral to target tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... The print component of Vision and Hearing is distributed ... Star, with a circulation of approximately 230,433 copies and ... distributed nationally through a vast social media strategy and ... outlets. To explore the digital version of the campaign, ... an exclusive interview with Mark DeMontis , sharing his ...
(Date:12/19/2014)... FRIDAY, Dec. 19, 2014 (HealthDay News) -- Injectable drug ... double the suicide attempt rate of other substance users, ... use is associated with the risk of suicide attempt ... the University of Montreal, said in a university news ... users. We wanted to know who among substance users ...
(Date:12/19/2014)... Los Angeles, CA (PRWEB) December 19, 2014 ... most up to date, current approach to weight ... with modern medical understanding. The professionals at the company ... challenging and the side effects of eliminating carbohydrates and ... tired, hungry and tempted to abandon their weight loss ...
(Date:12/19/2014)... Novellus Healthcare Communications, LLC announces ... Clinics™, an independent journal that provides practical information ... for patients inside the pharmacy and retail clinics. ... optimal access to quality care, Inside Patient Care: ... team treating and coordinating patient care in pharmacies ...
(Date:12/19/2014)... December 19, 2014 Slone ... diagnostic, personalized medicine, healthcare information technology, and laboratory ... position of Chief Operating Officer. The announcement comes ... marked by a strengthened presence in Boston and ... "Leslie lives and breathes the client experience," said ...
Breaking Medicine News(10 mins):Health News:Mark DeMontis, Founder of Courage Canada, shares his passion for bringing hockey to those affected by blindness in Mediaplanet’s “Vision and Hearing” campaign 2Health News:Cocaine, Amphetamines May Up Injection Drug Users' Suicide Risk 2Health News:Diet Doc Incorporates Appetite Zap into their Already Impressive Collection of Diet Products to Jump Start the Metabolism and Burn Fat 4X Faster 2Health News:Diet Doc Incorporates Appetite Zap into their Already Impressive Collection of Diet Products to Jump Start the Metabolism and Burn Fat 4X Faster 3Health News:Diet Doc Incorporates Appetite Zap into their Already Impressive Collection of Diet Products to Jump Start the Metabolism and Burn Fat 4X Faster 4Health News:The Transformation of Retail Pharmacies into a Healthcare Delivery Center 2Health News:The Transformation of Retail Pharmacies into a Healthcare Delivery Center 3Health News:Slone Partners Promotes Leslie Loveless to Chief Operating Officer 2
... Provides Guidance for 2009VANCOUVER, Feb. 19 /PRNewswire-FirstCall/ - QLT Inc. ... "Company") today reported its financial results for the fourth quarter ... as issued its guidance for 2009. Unless specified otherwise, all ... GAAP. , "2008 was a pivotal year for us as ...
... Corporation (NYSE: GTS ), the largest managed care ... for the 12 months,ended December 31, 2008. Net income of ... net loss of $33.9 million, or $1.06 per diluted,share, in ... , 2008 Highlights, -- ...
... the taste; parents love that it is made in a ... In response to viral marketing, growing demand and increasing sales, ... distribution, including 128 locations of Raley,s Family of Fine ... no-refrigeration almond butter. Demand prompted a move to a ...
... 6-Month Subscription to its Vulnerability Management and Endpoint Protection Suite ... Reduce TCO , ... Scottsdale, Ariz. ... in security management, announced the launch of its global campaign, ...
... Health Information Exchange Can Progress in California and ... A statewide system to provide physicians with secure ... to launch in 23 Orange County emergency departments. ... collaboration between the statewide California Regional Health Information ...
... Groups Provide Information on Cardiac Medical Imaging Technology ... is American Heart Month and 44 million American ... for heart disease.(Logo: http://www.newscom.com/cgi-bin/prnh/20090218/DC72747LOGO-a ) , ... the leading cause of death in women over ...
Cached Medicine News:Health News:QLT Announces Fourth Quarter and Year End 2008 Results 2Health News:QLT Announces Fourth Quarter and Year End 2008 Results 3Health News:QLT Announces Fourth Quarter and Year End 2008 Results 4Health News:QLT Announces Fourth Quarter and Year End 2008 Results 5Health News:QLT Announces Fourth Quarter and Year End 2008 Results 6Health News:QLT Announces Fourth Quarter and Year End 2008 Results 7Health News:QLT Announces Fourth Quarter and Year End 2008 Results 8Health News:QLT Announces Fourth Quarter and Year End 2008 Results 9Health News:QLT Announces Fourth Quarter and Year End 2008 Results 10Health News:QLT Announces Fourth Quarter and Year End 2008 Results 11Health News:QLT Announces Fourth Quarter and Year End 2008 Results 12Health News:QLT Announces Fourth Quarter and Year End 2008 Results 13Health News:QLT Announces Fourth Quarter and Year End 2008 Results 14Health News:QLT Announces Fourth Quarter and Year End 2008 Results 15Health News:QLT Announces Fourth Quarter and Year End 2008 Results 16Health News:QLT Announces Fourth Quarter and Year End 2008 Results 17Health News:QLT Announces Fourth Quarter and Year End 2008 Results 18Health News:QLT Announces Fourth Quarter and Year End 2008 Results 19Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 2Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 3Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 4Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 5Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 6Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 7Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 8Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 9Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 10Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 11Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 12Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 13Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 14Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 15Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 16Health News:Triple-S Management Corporation Reports 2008 Results at High End of Guidance Range 17Health News:Barney Butter Almond Butter Hits Shelves of all Raleys /BelAir /Nob Hill Stores 2
(Date:12/17/2014)... 17, 2014 , ... a hub of information concerning the biopharmaceutical Group,s national and ... further addition to the recently launched institutional website that is ... been enriched by a new chapter in the fascinating story ... richly detailed and panoramic hub on the world of clinical ...
(Date:12/17/2014)... 17, 2014  IGI Laboratories, Inc. (NYSE MKT: IG; ... its offering of $125 million aggregate principal amount of ... Notes were offered and sold only to qualified institutional ... of 1933, as amended (the "Securities Act"). ... 3.75% per year, payable semiannually in arrears on June ...
(Date:12/17/2014)... and RALEIGH, N.C. , ... Communications, LLC (CTMC), and Integrated Clinical Trial Services, ... and retention for clinical trials announce that they ... Trial Marketing Services (i-CTMS). i-CTMS will provide a ... to pharmaceutical, biotechnology and medical device companies. ...
Breaking Medicine Technology:Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 2IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 4Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3
... PARSIPPANY, N.J., Nov. 30, 2011  Watson Pharmaceuticals, Inc. (NYSE: ... Inc., has launched an authorized generic version of LIPITOR® ... exclusive agreement with Pfizer Inc.  Watson began shipping the ... adjunct to diet to reduce elevated total cholesterol, LDL, ...
... 2011  Vantage Health (OTC:BB – ticker symbol VNTH), ("Company"), ... Health Tanzania Limited ("VHTL"), was awarded Lot 1, Lot ... es Salaam ("University") pharmaceutical and medical supply tender number ... value for lot 1, lot 2 and lot 3 ...
Cached Medicine Technology:Watson Launches Generic LIPITOR® 2Watson Launches Generic LIPITOR® 3Vantage Health 51% Owned Tanzanian Subsidiary Awarded Lot 1, Lot 2 and Lot 3 of University of Dar Es Salaam Pharmaceutical and Medical Supply Tender 2Vantage Health 51% Owned Tanzanian Subsidiary Awarded Lot 1, Lot 2 and Lot 3 of University of Dar Es Salaam Pharmaceutical and Medical Supply Tender 3
... Medical Parameters Monitoring (MPM) devices allow physicians ... chronically ill. With Aerotels MPM equipment, patients ... own homes while physicians conduct routine and ... With the MPM system, data is automatically ...
... Eyelid Implants feature a proprietary three-dimensional design ... ocular globe. The Contour Eyelid Implant ... eyelid because the tapered lower edge and ... Surfaces and edges of the implant are ...
Use the Oculus Mesotest II before and after IOL or refractive surgery. Selectable Landolt ring positions. Accurate measurements in four contrast levels, with and without glare, independent of the pup...
... state-of-the-art electronic medical record the development of ... a proven, comprehensive electronic medical record designed ... at the point of care and to ... through the Internet. AmkaiCharts chronicles patient history, ...
Medicine Products: