Navigation Links
One Step Closer to New Diabetes Treatment
Date:11/25/2009

Researchers identify role mitochondrial function plays in insulin production

WEDNESDAY, Nov. 25 (HealthDay News) -- Mitochondrial damage causes people with type 2 diabetes to lose insulin-producing cells, a finding that could lead to new treatments, U.S. researchers say.

Mitochondria provide energy for cellular activity.

The researchers found that when insulin-producing beta cells in the pancreas can't respond to circulating insulin, it triggers a "molecular cascade" that damages the normal action of a certain molecular receptor on the surface of the mitochondria. The damaged mitochondria then begin to destroy adenosine triphosphate, the prime fuel for cellular activity. As a result, the beta cells die.

The study was published online Nov. 24 in the journal PLoS One.

"Mitochondrial function is a very fundamental aspect of how beta cells produce insulin, and this research shows its direct relation with insulin signaling," study co-author Dr. E. Dale Abel, chief of the endocrinology and metabolism division at the University of Utah School of Medicine in Salt Lake City, said in a news release from the Joslin Diabetes Center.

The researchers plan to look for proteins that may offer potential targets for drug treatment to prevent this kind of beta cell death.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about diabetes.



-- Robert Preidt



SOURCE: Joslin Diabetes Center, news release, Nov. 23, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. UGA researchers 1 step closer to elusive cancer vaccine
2. Research Gets Closer to Origin of Parkinsons Disease
3. Study Gets Closer to Origins of Leukemia
4. Bug guts map brings scientists closer to understanding different bugs role in the body
5. UBs bioblower closer to protecting soldiers from biological attack
6. Closer Analysis Shows Consumer Groups Make Gains in Stem Cell Patent Challenges Against WARF; Appeal Still Planned Against Narrowed Claims
7. Governor Rendell Says Pennsylvania is One Step Closer to Providing Access to Health Care for Pennsylvanias Uninsured
8. Breast Cancer Lymph Node Biopsy May Need Closer Look
9. Thousands of volunteers needed to help bring cure for cancer closer
10. Family Healthcare Contributions Edge Closer to Full Months Salary, Says Aon Consulting
11. Accelerated Cure Project for Multiple Sclerosis is One Thousand Steps Closer to a Cure for MS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2017)... ... June 24, 2017 , ... The Pennsylvania Athletic Trainers’ ... Bayfront and Erie Convention Center on June 8-10. The weekend consisted of ... bowl, award and scholarship presentations, and professional networking. , On Friday June ...
(Date:6/24/2017)... , ... June 24, 2017 , ... The weather is ... time outdoors. Home and business owners should be aware that the summer months provide ... In fact, mechanical locks and keys can be negatively affected from direct exposure to ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Rhode Island ... Care Management Alerts and Dashboards, an innovative new service enabling healthcare providers to ... Care Management Alerts and Dashboards provide near real-time data about patients admitted to ...
(Date:6/23/2017)... ... June 23, 2017 , ... By scoring 100% for fiscal ... four-star rating from premier online charity evaluator, Charity Navigator, validating ANRF's work as a ... all charities reviewed by Charity Navigator and earns ANRF a spot on their “ ...
(Date:6/23/2017)... ... June 24, 2017 , ... Studies show evidence that ... the risk of visual loss in these patients. , But how often do ophthalmologists ... smoking cessation to patients at risk of or with early symptoms of AMD? A ...
Breaking Medicine News(10 mins):
(Date:6/2/2017)... , June 2, 2017  NxStage Medical, Inc. (Nasdaq: ... care, today announced new findings demonstrating positive biochemical outcomes ... System One™. The data will be presented at ... Madrid, Spain . ... Improve Home Dialysis Network in Europe ...
(Date:5/30/2017)... AVIV, Israel , May 30, 2017 ... stage pharmaceutical Company specializing in the development of ... will present a company overview at three upcoming ... The 7th Annual LD Micro Invitational: ... Date:                     ...
(Date:5/24/2017)... May 24, 2017  ivWatch LLC today announced ... (OEM) Board to enable seamless integration of ivWatch,s ... systems, infusion pumps and other devices. By integrating ... able to help health care customers deliver a ... related to IV therapy. "The ivWatch ...
Breaking Medicine Technology: