Navigation Links
One Shot May Someday Replace Six for Rabies
Date:9/23/2009

Experimental vaccine offers hope for millions of people worldwide, researchers say

WEDNESDAY, Sept. 23 (HealthDay News) -- An experimental rabies vaccine that may require only one injection produced promising results in animals, U.S. researchers report.

Currently, people exposed to rabies have to undergo six shots over 28 days -- five injections of the rabies vaccine and one injection of rabies immunoglobulin.

The new replication-deficient rabies virus vaccine lacks a key gene called the matrix (M) gene, according to a news release from Thomas Jefferson University, where the research was performed.

"The M gene is one of the central genes of the rabies virus, and its absence inhibits the virus from completing its life cycle. The virus in the vaccine infects cells and induces an immune response, but the virus is deficient in spreading," James McGettigan, an assistant professor of microbiology and immunology at Jefferson Medical College at the university in Philadelphia, said in the news release.

The immune response triggered by the vaccine is so strong that a single injection may be sufficient to protect a person who has been exposed to rabies, usually through being bitten by a rabid animal. The vaccine produced a rapid and efficient anti-rabies immune response in mice and non-human primates. The vaccine also appears to be efficient when used both before and after exposure to rabies, according to the research, which was published online Sept. 18 in the Journal of Infectious Diseases.

Worldwide, rabies kills between 40,000 and 70,000 people each year. Rabies is endemic in developing regions, where the six-shot anti-rabies regimen isn't feasible for many people due to cost and availability. Each year, about 10 million people undergo the post-exposure regimen, according to the World Health Organization.

"Developing countries do not have the resources to vaccinate people six times after exposure, so many of these 10 million do not receive the full regimen," McGettigan said. "Therefore, simpler and less expensive vaccine regimens are needed. The alternative may also be to treat people pre-exposure, as they are with many of the current vaccines used. Although our vaccine was tested primarily to be a post-exposure vaccine, the data we collected show it would be effective as a pre-exposure vaccine as well."

More information

The U.S. Centers for Disease Control and Prevention has more about rabies.



-- Robert Preidt



SOURCE: Thomas Jefferson University, news release, Sept. 21, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Patch Shots May Someday Replace Injections
2. Vaccine May Someday Thwart Ear Infections
3. UCF researchers nanoparticles could someday lead to end of chemotherapy
4. Alzheimers Drug May Someday Help Head Trauma Victims
5. Gene-Based Sunscreen Might Someday Prevent Skin Cancer
6. Advanced Alopecia Treatment developed by London-based Hair Replacement Provider
7. NorthShore University HealthSystem First in Illinois to Perform Remarkable Robotic Arm Guided Partial Knee Replacement Surgery
8. New Published Diet Study Reveals Meal Replacements as Top Strategy for Weight Loss
9. UK study finds meal replacements aid weight loss
10. New DrainEx(TM) Catheter Simplifies Insertion and Replacement
11. New DrainEx(TM) Catheter Simplifies Insertion and Replacement
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
One Shot May Someday Replace Six for Rabies 
(Date:7/26/2017)... ... July 26, 2017 , ... An inventor from Salisbury, N.C., ... haven’t yet seen an effective and dignified way to keep leeches in place during ... CUP." , This invention provides an effective way to keep a leech in place ...
(Date:7/26/2017)... ... July 26, 2017 , ... A major challenge many labs ... freeze drying samples and a lengthy freeze dry cycle are a few common challenges ... drying techniques, as well as new accessories and advancements in laboratory freeze dryers that ...
(Date:7/26/2017)... ... July 26, 2017 , ... ... the cloud ; today announced the availability of its latest data protection solution ... use control console for Data Discovery, Classification, Encryption and Digital Rights Management; GTB ...
(Date:7/26/2017)... , ... July 26, 2017 , ... ... or “Isodiol”) a global cannabis innovator, specializing in the development of pharmaceutical and ... from April 1, 2017 to June 30, 2017. Iso International LLC recorded unaudited ...
(Date:7/25/2017)... St. Louis, MO (PRWEB) , ... July 25, 2017 , ... ... (HDIS) in St. Louis, Missouri. The company has achieved record-breaking sales for ... multiple departments over the next 12 months. , The upcoming year offers excitement and ...
Breaking Medicine News(10 mins):
(Date:7/27/2017)... EXTON, Pa., July 27, 2017  West Pharmaceutical Services, ... financial results for the second-quarter 2017 and updated financial ... Second-Quarter 2017 Highlights Reported ... 2.5% over the prior-year quarter. Net sales at constant ... 2017 reported-diluted EPS was $0.51, compared to $0.60 in ...
(Date:7/26/2017)... NEW YORK , July 26, 2017 ... Annual Prix Galien USA Award ... honors, the Prix Galien Award recognizes outstanding biomedical and technology ... To qualify, each candidate must be ... the last five years and demonstrate tremendous potential to impact ...
(Date:7/24/2017)... 24, 2017  Diplomat Pharmacy, Inc. (NYSE: ... second quarter 2017 operating results on Monday, August 7, ... follow at 5:00 p.m. ET. ... a live broadcast of the conference call by dialing ... code 51641230 approximately 15 minutes prior to the call. ...
Breaking Medicine Technology: