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Onconova Therapeutics presents new data demonstrating radioprotection by Ex-RAD at RRS annual meeting
Date:9/27/2010

on study in mice demonstrated that Ex-RAD dosed orally or by injection prior to lethal whole body irradiation (WBI) produced significant enhancement in survival for both Ex-RAD treated groups versus placebo.

Results from the radiomitigation experiment (where the drug is administered after exposure to lethal radiation), using both injection and oral methods of delivery demonstrated that Ex-RAD treated animals had comparably high rates of survival in both groups.

Hence, oral Ex-RAD was found to be effective in both prophylactic pre-treatment and mitigation post-treatment settings.

"Years of collaborative work are resulting in great progress with Ex-RAD in the laboratory and the clinic and Ex-RAD is the focus of several posters and a key presentation within the RSS scientific and educational track," said Manoj Maniar, PhD, Senior Vice President for Product Development of Onconova. "We are very excited to see the acceleration and new developments within radioprotection, specifically in oral prophylaxis and treatment. Ex-RAD holds a unique position among developing products with the potential to benefit people exposed to whole body radiation."

Onconova oral presentation and poster sessions on Ex-RAD at the Radiation Research Society meeting:

Oral Presentation

WEDNESDAY, SEPTEMBER 29, 2010

  • No. MS701 (Mini-Symposium Presentation, 10:15 AM-12:15 PM) Radioprotection and Radiomitigation Properties of Ex-RAD Upon Oral Administration Manoj Maniar1, Ramesh Kumar1, Bo-Hyun Moon2, David Taft3, Kamal Datta2; 1Onconova Therapeutics, Inc., 2Georgetown University, Department of Biochemistry and Molecular & Cellular Biology and Lombardi Comprehensive Cancer Center, 3Long Island University, Arnold & Marie Schwartz College of Pharmacy

Poster Sessions Radiation Protection Protection / Mitigators / Treatment

SUNDAY, SEPTEMBER 26, 2:00 pm-2:45 pm, 2010, Haleakala Foyer

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Source:Eurekalert

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