Navigation Links
Oncolytic viruses mediating anti-tumor immunity in human cancer patients
Date:5/18/2010

The researchers of the University of Helsinki, and Oncos Therapeutics, the biotech company developing new cancer therapeutics based on the next generation oncolytic viruses, published initial results from their Advanced Therapy Access Program in Cancer Research. The therapy program is based on scientific research at the University of Helsinki and serves as the foundation for ongoing clinical development.

The results demonstrate an anti-tumor immunity of oncolytic viruses published for the first time in humans and indicate the strong efficacy of the next generation viruses against solid tumor cancers. As of today, 200 patients have been treated with oncolytic virus therapy in the company's Advanced Therapy Access Program.

"This is the first time it has been shown in humans that oncolytic viruses can be used for the induction of anti-tumor immunity. The GMCSF armed oncolytic adenovirus can mediate anti-tumor immunologic responses by recruiting natural killer cells and by the induction of tumor-specific cytotoxic T-cells", explains research professor Akseli Hemminki, the CSO and co-founder of Oncos.

"Anti-tumor immunity plays a major role in the strong efficacy results. We are starting clinical trials with CGTG-102, which is further improved compared of the virus described in this publication", comments Pekka Simula, the CEO and co-founder of Oncos.

The Cancer Research article reports strong safety and efficacy results in patients with advanced cancer progressing after available chemotherapy options. Out of the 15 radiologically evaluable patients 2 had complete responses (13%), 5 patients had stable disease (33 %) and 1 had a partial response (6 %). Therefore, the clinical benefit rate was 47% according to the RECIST criteria. Responses were frequently seen in both injected and non-injected tumors. The safety profile was favorable with no grade 4-5 side effects realized.

"It has been impressive to see how powerful and consistent the oncolytic adenovirus platform is for directing the body's own immune system against tumor cells" says Dr. Vincenzo Cerullo, the scientist who led the project at the University of Helsinki Cancer Gene Therapy Group (CGTG).


'/>"/>

Contact: Timo Ahopelto
timo.ahopelto@oncos.com
358-400-569-628
University of Helsinki
Source:Eurekalert

Related medicine news :

1. Oncos Therapeutics raises €4 million ($5.3 million) to develop oncolytic viruses into cancer treatment
2. Mild-mannered metabolic helper rushes to fight invading viruses, researchers report
3. UBC graduate student finds a start/stop switch for retroviruses
4. New Study: Improved Immune System with Gene-Eden, a Natural Antiviral Supplement that Targets Chronic Viruses
5. Researchers find broad spectrum antiviral that fights multitude of viruses
6. Compound found that targets wide range of viruses
7. Chemotherapy plus synthetic compound provides potent anti-tumor effect in pancreatic cancers
8. Poorly understood cell plays role in immunity against the flu
9. BHM Healthcare Congratulates PORT Human Services: First to Receive CABHA Status
10. The cost of medicalizing human conditions
11. It was brawn over beauty in human mating competition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... Two years ago, Arizona State ... watched live by 1 million viewers and won numerous honors, including the region’s ... at the Walter Cronkite School of Journalism and Mass Communication are following up ...
(Date:12/2/2016)... Angeles, CA (PRWEB) , ... December 02, 2016 , ... For over twenty-four years, ... lien basis to help personal injury victims find high quality medical care. When the ... Los Angeles area. Fast forward to present day and the now ten-page directory features ...
(Date:12/2/2016)... ... December 02, 2016 , ... Advanced Inc., a leading provider of ... Bice, CPA, MBA to serve as Advanced Inc.’s Chief Financial Officer, effective December 1, ... Jason brings extensive financial and operational leadership experience to Advanced Inc. He began his ...
(Date:12/2/2016)... ... 2016 , ... Center for Autism and Related Disorders (CARD) Portland today announced ... disorder (ASD) and other developmental disabilities. The group, which is being launched with the ... the opportunity to share stories and advice, seek help, and continue their education on ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... U.S. Surgeon ... interview with Mediaplanet, Dr. Murthy explains how he was inspired to practice medicine at ... learned that medicine is about more than making diagnoses and prescribing medicine,” he states. ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... , December 5, 2016 BioLineRx ... in-licensing and developing promising therapeutic candidates, presents positive Phase 2a ... the Company,s leading oncology platform at the ongoing 58th American ... San Diego, California . ... , , ...
(Date:12/5/2016)... The global  non-invasive prenatal testing market  is anticipated ... by Grand View Research, Inc. Evolution of prenatal testing in the form ... screening and invasive diagnostic testing to determine the likelihood of fetal abnormality ... forecast period. Continue Reading ... ...
(Date:12/4/2016)... -- Johnson & Weaver, LLP announces that a class action ... Holdings, Inc. (NYSE: ZBH )  securities during the ... "Class Period"). Zimmer Biomet provides musculoskeletal healthcare products ... such as knee and hip reconstructive products. ... , , ...
Breaking Medicine Technology: