Navigation Links
Oncolytic viruses effectively target and kill pancreatic cancer stem cells
Date:5/9/2011

Oncolytic viruses quickly infect and kill cancer stem cells, which may provide a treatment for tumors that are resistant to conventional chemotherapy and radiation, particularly pancreatic cancer, according to new research from Memorial Sloan-Kettering Cancer Center in New York. The findings are especially important since pancreatic cancer has a poor prognosis and is difficult to detect and treat at early stages.

Investigators led by Joyce Wong, MD, surgical researcher with Memorial Sloan-Kettering Cancer Center, investigated whether they could use oncolytic viruses, which are naturally occurring viruses that have been genetically engineered to be safe and express tracking genes, as a possible therapy against pancreatic cancer stem cells. These stem cells are thought to cause disease recurrence and metastasis, even after therapy, and oncolytic viruses may offer a new treatment strategy.

"What we learned is that oncolytic viruses have been engineered to selectively target cancer cells and have a low toxicity profile in animal studies," said Dr. Wong. "Targeting the cancer stem cell may enhance our ability to eradicate tumors and prevent future recurrence of disease."

While much research has been performed on isolating the cancer stem cell from various hematologic cancers, this research was based on the presence or absence of certain cell surface markers. Numerous mechanisms of how these cancer stem cells resist chemotherapy and radiation have also been examined. But to date, there have not been any studies evaluating whether genetically engineered viruses can target and kill pancreatic cancer stem cells.

Investigators sought to determine whether the viruses containing a marker gene that expresses green fluorescent protein could infect pancreatic cancer stem cells and ultimately kill the cancer stem cell. Their findings were promising and documented that viral activity was correlated with green fluorescent protein expression.
'/>"/>

Contact: Amy Levey
alevey@gymr.com
312-791-6715
Digestive Disease Week
Source:Eurekalert

Page: 1 2

Related medicine news :

1. BUSM researchers show an oncolytic virus switches off cancer cell survival signal
2. Oncolytic viruses mediating anti-tumor immunity in human cancer patients
3. Oncos Therapeutics raises €4 million ($5.3 million) to develop oncolytic viruses into cancer treatment
4. Cold Viruses Appear Linked to Type 1 Diabetes
5. Flu Viruses Gaining Resistance, Study Confirms
6. Potential new treatment for deadly nipah and hendra viruses identified by Weill Cornell researchers
7. Targeting hit-and-run cancer viruses
8. Researchers find function of proteins that can enhance the progression of viruses and cancer cells
9. To attack H1N1, other flu viruses, gold nanorods deliver potent payload
10. Mount Sinai discovers bone marrow plays critical role in enhancing immune response to viruses
11. Mild-mannered metabolic helper rushes to fight invading viruses, researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... ... July 07, 2015 , ... CareSync proudly ... be recognized by the White House as a “Champion of Change” for Precision ... Medicine Initiative, the Champions of Change program recognizes Gleason and eight other extraordinary ...
(Date:7/6/2015)... ... 2015 , ... For over twenty years, Doctors on Liens has ... the company’s history the goal has been to be a comprehensive network of doctors ... And while Doctors on Liens has certainly achieved that goal, the addition of ...
(Date:7/6/2015)... ... July 06, 2015 , ... Respected southern California personal ... in 2015, marking him as an attorney who has sharp legal skills as well ... Client Distinction Award for 2015 from Martindale-Hubbell and a Top 10 Award from The ...
(Date:7/6/2015)... ... ... University of Pittsburgh Cancer Institute (UPCI) scientists recently led a ... available tests that better incorporate personalized medicine into diagnosing the condition. , Their ... published in the July issue of the scientific journal Thyroid . The ...
(Date:7/6/2015)... Signal Hill, CA (PRWEB) , ... July 06, 2015 , ... ... Doctors on Liens , the leading network of doctors working on a lien ... chiropractor with Doctors on Liens. , The daughter of two Cambodian refugees, Dr. Lim ...
Breaking Medicine News(10 mins):Health News:White House names Champions of Change for Precision Medicine: CareSync COO Recognized 2Health News:White House names Champions of Change for Precision Medicine: CareSync COO Recognized 3Health News:Doctors on Liens Adds Transportation to Its Ever-Expanding Network 2Health News:Doctors on Liens Adds Transportation to Its Ever-Expanding Network 3Health News:Fernando D. Vargas Awarded Top Honors in Personal Injury Law for 2015 from Two Respected Independent Organizations 2Health News:Fernando D. Vargas Awarded Top Honors in Personal Injury Law for 2015 from Two Respected Independent Organizations 3Health News:Pitt Scientists Lead Consensus Guidelines for Thyroid Cancer Molecular Tests 2Health News:Pitt Scientists Lead Consensus Guidelines for Thyroid Cancer Molecular Tests 3Health News:Pitt Scientists Lead Consensus Guidelines for Thyroid Cancer Molecular Tests 4Health News:Pitt Scientists Lead Consensus Guidelines for Thyroid Cancer Molecular Tests 5Health News:Respected Chiropractor Opens Office in Signal Hill/Cambodia Town and Joins Doctors on Liens 2
... Reporter , WEDNESDAY, Feb. 15 (HealthDay News) -- Researchers report ... kicking off puberty in humans, a finding that offers insight ... who suffer from a rare disease that prevents the start ... family whose members have suffered from the disease confirmed that ...
... , WEDNESDAY, Feb. 15 (HealthDay News) -- ... or stroke, peripheral artery disease is often unrecognized and ... scientific statement released Wednesday. Peripheral artery disease is ... and other materials in the blood vessels outside the ...
... California reported the largest decline in drunk-driving deaths of any ... and a $232,000 grant from the California Office of Traffic ... to UC Irvine,s Health Education Center is helping to keep ... College DUI Awareness Program, UCI has organized nine universities into ...
... -- Hospitalization for underage drinking is common in the United ... estimated total cost for these hospitalizations is about $755 million ... also found geographic and demographic differences in the incidence of ... the Journal of Adolescent Health . Of ...
... potential for making medical isotopes with X-rays from a particle ... to the large scale. The Canadian Isotope Project, led by ... Research Council of Canada, and medical researchers in Winnipeg, Ottawa ... production levels with the delivery of a new particle accelerator ...
... TAMPA, Fla. A recent study conducted by researchers at ... in Rochester, Minn., has found that female cancer survivors receiving ... screening and who had never had cancer. The study ... Journal of Clinical Oncology . Researchers surveyed 19,948 women ...
Cached Medicine News:Health News:Gene Linked to Start of Puberty 2Health News:Circulatory Disorder Not Studied Enough in Women, Experts Say 2Health News:UCI leads multicampus collaboration to reward use of designated drivers 2Health News:Mayo Clinic: Hospitalization of US underage drinkers common, costs $755 million a year 2Health News:Canadian Isotope Project enters final stretch 2Health News:Female cancer survivors have 'worse health behaviors' than women with no cancer history 2
(Date:7/6/2015)... 2015 Celtaxsys, Inc., a clinical stage pharmaceutical ... rare and orphan inflammatory disease indications, announced today that ... Drug Administration (FDA) to begin a Phase 2 clinical ... adult CF patients in the US. The regulatory submissions ... will be filed soon after. This groundbreaking clinical ...
(Date:7/6/2015)... SOUTH SAN FRANCISCO, Calif. , July ... ), a leading global pharmaceutical company, and Oculeve, a ... for dry eye disease, today announced that they have ... Oculeve in an all-cash transaction.  Under the terms of ... million upfront payment and commercialization milestone payments related to ...
(Date:7/6/2015)... -- China Information Technology, Inc. (the "Company" or "CNIT") ... platform, exchange, and big data solutions in ... its mobile app for Healthcare One Pass, ushering in ... devices. The Company jointly hosted the launch ceremony with ... Shenzhen News Net.   The mobile app for ...
Breaking Medicine Technology:Celtaxsys, Inc. Gains FDA Clearance for Landmark Phase 2 Trial of Anti-Inflammatory Treatment for Cystic Fibrosis (CF) 2Celtaxsys, Inc. Gains FDA Clearance for Landmark Phase 2 Trial of Anti-Inflammatory Treatment for Cystic Fibrosis (CF) 3Allergan to Acquire Oculeve Dry Eye Disease Development Programs 2Allergan to Acquire Oculeve Dry Eye Disease Development Programs 3Allergan to Acquire Oculeve Dry Eye Disease Development Programs 4CNIT Launches the Mobile App for Healthcare One Pass 2CNIT Launches the Mobile App for Healthcare One Pass 3CNIT Launches the Mobile App for Healthcare One Pass 4
... ... Anticancer Drug, HOUSTON, ... to families, workplaces and communities, and many,Houstonians are aware of ... the CHRISTUS Stehlin Foundation for,Cancer Research, a nationally recognized leader ...
Journalists and other readers should disregard the news release "Oramed,Pharmaceuticals Launches Phase 1A Trials of its Insulin Suppository",OTC:ORMP, issued earlier today. The release was transmitted...
Cached Medicine Technology:Local Research Foundation Achieves Milestone in Fight Against Cancer 2Local Research Foundation Achieves Milestone in Fight Against Cancer 3
... Split Splint reduces PIP joint or DIP joint ... to put on. Soft gel-lining cushions injured fingers ... begin earlier for faster, more successful therapy results. ... and at night to maintain gains in motion. ...
... FoamWrap Final Flexion Wraps restore full PIP ... or when lost due to arthritic changes. ... foam-lined material hugs the finger to prevent ... restore motion. One size. Sold in packages ...
One splint does it all....
... of minor knee pain like arthritis, tendonitis ... with the motion of the knee, applying ... tendon and assisting in the relief of ... with high density foam padding molds itself ...
Medicine Products: