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Oncologist at the Children's Hospital of Philadelphia to Chair International Childhood Cancer Organization
Date:12/7/2009

drugs being developed to treat cancer in children. During the eight years that Dr. Adamson led this effort, the collaborating sites conducted more than 25 studies designed to test the safety of novel anticancer drugs.

"Scientific discovery today is occurring at an unprecedented pace, but the clinical trial system that historically worked so well is showing a diminishing rate of return in our ability to cure children," said Dr. Adamson. "This system was not designed to rapidly bring findings from the bench to the bedside, and a transformation of the system's approach is needed to propel translational efforts on an international scale. I hope to fully leverage the emerging discoveries being made at a rapid pace by transforming how research moves from the bench to the bedside in a very large collaboration."

COG was the first group to recognize the importance of collaboration in pediatric research, as even common childhood cancers are rare enough that no one center treats the number of children required for large-scale clinical trials. Today, more than 90 percent of the 12,500 children diagnosed with cancer each year in the United States are treated at COG institutions, with the Children's Hospital of Philadelphia being one of the largest such centers in the world.

Emerging research shows that even the more common childhood cancers are actually a mix of different diseases, each potentially requiring a different specific therapy. Creating such disease-targeted therapies for children with cancer requires a better pathway for moving from the bench to the bedside, which Dr. Adamson will lead through expanding COG's role at Children's Hospital and fostering new and enhanced collaborations with COG sites throughout the world.

"We are looking forward to working with Dr. Adamson in his new leadership role with the Children's Oncology Group," said John L. Lehr, President and CEO of CureSearch National Childhood Cancer Foundation. "
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SOURCE The Children's Hospital of Philadelphia
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