Navigation Links
Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1
Date:1/29/2009

Scientists have uncovered an interesting connection between two important protein kinase signaling pathways that are associated with cancer. The research, published by Cell Press in the January 30th issue of the journal Molecular Cell, may direct new therapeutic strategies for multiple types of cancer.

The protein kinase LKB1 is a known tumor suppressor and the LKB1-AMPK signaling pathway couples energy metabolism with cell growth, proliferation and survival. "Mutations in LKB1 are not frequent in human cancers and it is not clear how tumor cells suppress the signaling pathway to gain growth advantage under conditions of energy stress (common in cancer cells)," explains senior study author Dr. Lewis C. Cantley from Beth Israel Deaconess Medical Center and Harvard Medical School.

Dr. Cantley and colleagues, including Dr. Bin Zheng, designed a study to investigate the molecular mechanisms associated with suppression of the LKB1-AMPK pathway in tumor cells. The researchers used malignant melanoma cells that often have a mutation called "V600E" in the RAF protein B-RAF. The RAF-MEK-ERK pathway is well established as a key regulator of cell growth, proliferation, differentiation and survival.

Mutations in the RAF kinase B-RAF have been found in many types of human cancer but, while oncogenic B-RAF V600E has been linked with tumor induction, growth, maintenance and progression, the specific molecular mechanisms have not been identified. Dr. Cantley's group found that melanoma cells with the B-RAF V600E mutation had impaired AMPK activation and that inhibition of B-RAF signaling activated AMPK.

The researchers went on to show that LKB1 was phosphorylated by two kinases that are downstream of B-RAF, ERK and Rsk. The phosphorylation of LKB1 interfered with the ability of LKB1 to bind and activate AMPK. Importantly, expression of mutant LKB1 that could not be phosphorylated resulted in activation of AMPK and an inhibition of me
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. MicroRNA controls expression of oncogenes
2. Colon Cancer Oncogene Discovered
3. Blocking Oncogene Can Stop Spread of Ovarian Cancer
4. Helicobacter pylori inhibits intercellular communication of cultured gastric cells
5. Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
6. Embryonic Stem Cell Protein Inhibits Melanoma
7. Penn scientists find a protein that inhibits Ebola from reaching out to infect neighboring cells
8. Ingredient found in green tea significantly inhibits breast cancer growth in female mice
9. Calorie restriction limits Calorie restriction inhibits, obesity fuels development of epithelial can
10. Calorie restriction inhibits, obesity fuels development of epithelial cancers
11. Grapefruit Compound Inhibits Hepatitis C Virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... New York, New York (PRWEB) , ... ... ... Nationally renowned trial attorney Jason T. Brown’s live lecture on pharmaceutical negligence ... from July 28th, 2015 was well received with a 94% approval rating ...
(Date:7/31/2015)... ... July 31, 2015 , ... As part of their company mission, ... support of animal welfare organizations is essential to the longevity of their business. ... the National Association of Professional Pet Sitters (NAPPS) annual Presents 4 Pets supply drive. ...
(Date:7/31/2015)... ... July 31, 2015 , ... Transfinder, a software company ... Total sales were up 16 percent year-over-year for the first six months ended June ... said he expected Transfinder to beat last year’s record-revenue mark of $10.4 million. , ...
(Date:7/31/2015)... , ... July 31, 2015 , ... ... “HARMONY 2015”, one of the industry’s premier thought leadership symposiums, hosted by ... and 6. The event attracts over 250 “C”-level executives, administrators, directors of ...
(Date:7/31/2015)... ... 2015 , ... Mullin/Ashley Associates , a Mid-Atlantic branding, ... Awards national competition for a marketing communications campaign created for Atlantic General ... Coastal Maryland and Southern Delaware. , A Bronze Award was won for the ...
Breaking Medicine News(10 mins):Health News:Re-Broadcast of Nationally Renowned Trial Attorney Jason T. Brown's Lecture on Pharmaceutical Negligence Now Available 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 3Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 4Health News:Transfinder Closes First Half of 2015 with Record Revenue 2Health News:Harmony Healthcare International Announces Speaker Line-up for “HARMONY 2015” 2Health News:Harmony Healthcare International Announces Speaker Line-up for “HARMONY 2015” 3Health News:Mullin/Ashley Associates Wins in the 2015 Aster Awards National Competition for Excellence in Medical Marketing 2
... stem cell researchers and other medical professionals from throughout ... in the heart of California,s Central Coast horse region ... cell therapy and regenerative medicine to treat horses and ... Conference will be held at the Santa Ynez Valley ...
... ... has added a new limited partner to its first venture fund, bolstering the fund’s ... , ... 2010 -- Mission Bay Capital, LLC, has added a new limited partner to its ...
... ... Book Will Make You Money” to give the keynote speech at the Affiliate Summit 2010 ... (PRWEB) ... Affiliate Summit event to learn and network about how to create and promote a successful ...
... ... suggest some health plans have used rescission to invalidate insurance policies for pre-existing ... consumers seeking to appeal their insurer’s decision to rescind their healthcare insurance have ... ...
... , ... Xserve Virtualization Offerings Capabilities for Businesses and Cloud Services Providers. , ... Renton, WA (PRWEB) February 24, 2010 ... announced that it is extending its server virtualization offerings for Apple environments with the ...
... ... small business. , ... (PRWEB) February 24, 2010 -- Verndale, a leading mid-market web technology and consultancy firm ... business, which is redefining the way websites are designed and managed. With Jumpstart, clients ...
Cached Medicine News:Health News:Horse stem cell conference to draw veterinarians and human-health professionals 2Health News:QB3 Adds Zcube As Limited Partner In Mission Bay Capital Fund 2Health News:QB3 Adds Zcube As Limited Partner In Mission Bay Capital Fund 3Health News:QB3 Adds Zcube As Limited Partner In Mission Bay Capital Fund 4Health News:Online Business Marketing Consultant Jim Kukral Chosen To Keynote Affiliate Summit 2010 2Health News:Online Business Marketing Consultant Jim Kukral Chosen To Keynote Affiliate Summit 2010 3Health News:Health Plan Policy Rescission Won't Go Away, Says NAIRO 2Health News:Health Plan Policy Rescission Won't Go Away, Says NAIRO 3Health News:Health Plan Policy Rescission Won't Go Away, Says NAIRO 4Health News:Parallels Launches Parallels Server for Mac Bare Metal Edition 2Health News:Parallels Launches Parallels Server for Mac Bare Metal Edition 3Health News:Parallels Launches Parallels Server for Mac Bare Metal Edition 4Health News:Verndale Announces the Release of Jumpstart 2Health News:Verndale Announces the Release of Jumpstart 3
(Date:7/30/2015)... , July 30, 2015  Tandem Diabetes Care®, ... company and manufacturer of the t:slim® and t:flex™ ... into non-exclusive Development Agreements with Dexcom, Inc. to ... pumps with the Dexcom G5 and G6 continuous ... next generation pump platform with Dexcom,s future CGM ...
(Date:7/30/2015)... special edition of #MedicareMonday on Medicare,s 50 th anniversary. As Medicare celebrates 50 ... highlighting the success of the prescription drug benefit, commonly referred to as Part D. ... and videos here: http://onphr.ma/1INp9qQ ... ... ...
(Date:7/30/2015)... and VANCOUVER , July ... ) announced today that it will report its second ... Company management will host a conference call and live ... overview of financial results, clinical development programs and a ... webcast, log on to the Investor Relations page of ...
Breaking Medicine Technology:Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 3Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3
... Calif. , June 16 SanBio Inc. ( www.san-bio.com ) ... approved the clinical testing of their SB623 regenerative medicine product in patients ... marrow stromal cells (MSCs) isolated from healthy adult donors. , ... This Phase 1/2a clinical trial will test ...
... June 16 Trius Therapeutics, Inc. announced today ... and Drug Administration (FDA), under the Special Protocol Assessment (SPA) ... for the oral dosage form of torezolid phosphate for treatment ... double-blind pivotal study will compare the efficacy and safety of ...
Cached Medicine Technology:SanBio Receives FDA Clearance to Initiate Cell Therapy Clinical Studies for Stroke Recovery 2Trius Therapeutics Obtains Special Protocol Assessment With FDA for Phase 3 Study of Torezolid Phosphate 2
Multispot HIV-1/HIV-2 is a rapid indirect EIA using recombinant and peptide antigens for simultaneous detection and differentiation of anti-HIV-1 and anti-HIV-2 antibodies in human serum or plasma....
Mini Aprons are half aprons with an easy-on, easy-off Velcro-style closure that fastens securely in seconds. Color-coded sizes for easy identification. Offers 0.5 mm Pb equivalent protection....
... the first in portability and performance. CTU is ... a flexible, portable system with the state-of-the-art features of ... to an "E" size tank and has an optional ... it is needed.,The CTU Travel Case allows you to ...
Pilot and control your analysis at a touch. 26 parameters CBC/DIFF with autoloader...
Medicine Products: