Navigation Links
Once-Daily Combo Works for New HIV Patients
Date:8/2/2008

Tazanavir/ritonavir as good as twice-daily dose of lopinavir/ritonavir, study says

FRIDAY, Aug. 1 (HealthDay News) -- Once-daily treatment with tazanavir/ritonavir (A/R) is as effective as twice-daily treatment with lopinavir/ritonavir (L/R) in HIV patients who are starting antiretroviral treatment for the first time, a European study shows.

Based on their findings, the researchers recommended once-daily A/R as a first-line treatment option for treatment-naive HIV patients since it has a number of advantages over the currently recommended twice-daily L/R.

The study included 883 treatment-naive HIV patients who were randomly assigned to receive A/R 300/100 milligrams once daily (440 patients) or L/R 400/100 milligrams twice daily (443 patients). Both regimens were in combination with tenofovir/emtricitabine 300/200 once daily, as is standard.

After 48 weeks of treatment, 78 percent of patients receiving A/R and 76 percent of those receiving L/R had a viral load of less than 50 copies per milliliters in their blood, and both groups showed similar increases in the numbers of immune system CD4 cells. Six percent of patients in both groups failed on the treatments, and two patients in the A/R group developed resistance mutations to treatment, compared with none in the L/R group.

Serious side effects were reported in 12 percent of the A/R patients and 10 percent of the L/R patients, but fewer A/R patients experienced treatment-related diarrhea (2 percent vs. 11 percent) and nausea (4 percent vs. 8 percent). None of the L/R patients developed jaundice, which occurred in 4 percent of A/R patients.

"In treatment-naive patients, atazanavir/ritonavir once-daily demonstrated similar antiviral efficacy to lopinavir/ritonavir twice daily, with less gastrointestinal toxicity but with a higher rate of hyperbilirubinaemia...the results of this study support the use of once-daily atazanavir/ritonavir as a recommended first-line treatment option, with a number of patient benefits over the currently recommended ritonavir-boosted twice-daily lopinavir for the treatment of HIV-infected antiretroviral-naive patients," the researchers concluded.

The study appears online in The Lancet, and was expected to be published in an upcoming print edition of the journal.

More information

The American Academy of Family Physicians has more about HIV medicines.



-- Robert Preidt



SOURCE: The Lancet, news release, Aug. 2, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Labopharms Once-Daily Tramadol Product Launched in South Korea, Australia, Romania and Austria
2. New Data Highlights Positive Results of Namenda (Memantine HCl) Once-Daily Extended-Release Formulation
3. FDA accepts Labopharms response for once-daily tramadol as complete Class 2 response
4. Labopharm Reaquires UK Sales And Marketing Rights to Its Once-Daily Tramadol Product
5. Labopharm Submits Complete Response to FDA as a Result of Outcome of Appeal Process for Once-Daily Tramadol
6. Labopharm Receives Response from FDA Regarding its Once-Daily Tramadol Product
7. FDA approves VYVANSE, first and only once-daily prodrug stimulant to treat ADHD in adults
8. Labopharm Appeals FDAs Decision on Once-Daily Tramadol to Next Supervisory Level After Additional Analysis Supports Efficacy
9. Once-Daily Insulin Shot Proves Effective in Study
10. A Once-Daily Oral Drug for Chronic Obstructive Pulmonary Disease That Treats COPD-Related Inflammation Could Achieve Blockbuster Status
11. Labopharms Once-Daily Tramadol Approved in South Korea and Australia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... From April ... of Urgent Care Medicine will host industry leaders for the annual spring Convention ... those in the industry adapt to the issues currently affecting urgent care and ...
(Date:4/28/2017)... ... April 28, 2017 , ... People are starting to ... “Wearing a hearing aid doesn’t have the stigma it had when great-grandpa wore his ... of Greater Boston, in a NALA North American Speaker Series (NASS) segment. ...
(Date:4/28/2017)... ... ... Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, Texas, has published a ... does not. Yisrayl says with so many titles and names for the Creator, it’s ... with a little Scripture, backed with a lot of research, the truth is undeniable. ...
(Date:4/28/2017)... , ... April 28, 2017 , ... ... for the North East region. Côté has 20+ years of experience within the ... Phytomer, Côté worked with an array of high-end cosmetic brands, retail brands and ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... advanced nutraceutical supplements, through its Nova Skin Sciences division, recently announced the launch ... a moisturizer with the power of an anti-aging concentrate. , Anogeissus ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 20, 2017 Research and Markets ... Pipeline and Market Prospects: Addressing Production Complexities Through Risk ... offering. ... "Global Biosimilar Pipeline and Market Prospects: Overcoming Production Complexities ... in-depth assessment of the current trends in the global ...
(Date:4/20/2017)... --  ZappRx, Inc ., a digital health company focused on ... it closed $25 million in Series B funding led by ... Seattle that is part of a ... B round included participation from SR One , who ... (formerly Google Ventures). As part of the financing, ...
(Date:4/20/2017)... 20, 2017 NeuroVive Pharmaceutical AB (Nasdaq ... positive preclinical results demonstrating anti-fibrotic effects with ... steatohepatitis (NASH), in an additional well-validated experimental ... has previously shown similar anti-fibrotic effects in ... scientists present novel data demonstrating anti-fibrotic effects ...
Breaking Medicine Technology: