Navigation Links
On the trail of a vaccine for Lyme disease: Yale researchers target tick saliva
Date:11/19/2009

New Haven, Conn. A protein found in the saliva of ticks helps protect mice from developing Lyme disease, Yale researchers have discovered. The findings, published in the November 19 issue of Cell Host & Microbe, may spur development of a new vaccine against infection from Lyme disease, which is spread through tick bites.

Traditionally, vaccines have directly targeted specific pathogens. This is the first time that antibodies against a protein in the saliva of a pathogen's transmitting agent (in this case, the tick) has been shown to confer immunity when administered protectively as a vaccine.

The Lyme bacterium known as Borrelia burgdorferi is transmitted by ticks. When it moves through the tick, it is coated with a tick salivary protein known as Salp15. The Yale team injected Salp15 into healthy mice and found that it significantly protected them from getting Lyme disease. When combined with outer surface proteins of B. burgdorferi, the protection was even greater.

Lead author Erol Fikrig, M.D. of Yale School of Medicine and Howard Hughes Medical Institute said, "The interaction between the Lyme disease agent and ticks is very complex, and the bacteria uses a tick salivary protein to facilitate infection of the mammalian host. By interfering with this important interaction, we can influence infection by the Lyme disease agent."

Several years ago there was a Lyme vaccine on the market that utilized just the outer surface proteins of the bacteria. It was taken off the market in 2002, and to date no other antigen has been tested in phase III clinical trials.

The authors believe this new strategy of targeting the saliva - the "vector molecule" that a microbe requires to infect a host - may be applicable not just to Lyme disease but to other insect-borne pathogens that also cause human illness.

"We believe that it is likely that many arthropod-borne infection agents of medical importance use vector proteins as they move to the mammalian host," Fikrig explained. "If so, then this paradigm, described with the Lyme disease agent, is likely to be applicable to these illnesses. Currently, we are working to determine if this strategy is likely to be important for West Nile virus infection, dengue fever, and malaria, among other diseases."


'/>"/>

Contact: Helen Dodson
helen.dodson@yale.edu
203-436-3984
Yale University
Source:Eurekalert  

Related medicine news :

1. Forbes Honors Susan G. Komen for the Cure Founder as Trailblazer
2. University of Leicester cancer researchers investigate smoking gun trail
3. MEDRAD Mobile MR Injector Meets Challenges of MR Trailers
4. Thompson Demands Solution to Formaldehyde Trailer Crisis
5. Smiling on the Campaign Trail - Cosmetic Dentist Michael Kosdon Rates the Candidates
6. TrailBlazer Announces Final Medicare Administrative Contractor Schedule for Claims Processing in Four States
7. Stress On The Campaign Trail, One Issue All The Candidates Agree On
8. What Drives Hillary to Get Up Every Morning and Hit the Campaign Trail?
9. AVMA Opposes Use of Double-Deck Trailers for Transporting Horses and Other Equines
10. Scientists Hot on Trail of New Antibiotics
11. The Age Factor on the Campaign Trail: When the Going Gets Tough, the Tough Keep Moving
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
On the trail of a vaccine for Lyme disease: Yale researchers target tick saliva
(Date:5/26/2016)... San Rafael, CA (PRWEB) , ... May 26, ... ... Studio will be offering campers a multitude of activities from daily practices, arts ... and self-confidence. , Camp Directors Amber East-D’Anna and Christy Evans have combined backgrounds ...
(Date:5/26/2016)... ... , ... Bunion Bootie , the manufacturer of the newest and best ... by customer demand over the Mother’s Day Weekend promotion. So much so, that they ... has completely replenished its inventory levels, it hopes to continue its current sales pace, ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... organization to provide strategic sales leadership and to further develop their rapidly expanding ... B.S. in Business Administration with a concentration in Marketing and an M.B.A. with ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... announce the launch of its brand equity product, Brandvantage. This breakthrough tool ... dynamic landscape of modern consumer decision-making. The proprietary framework incorporates attitudes, behavior ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... announce that it has successfully completed another Health Canada inspection and has received ... Canada. The rating resulted from a Good Manufacturing Practices (GMP) inspection conducted at ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... May 25, 2016 According to ... Development, Growth and Demand Forecast to 2022 - Industry ... and Others)" published by P&S Market Research, the global ... in 2015, and it is expected to grow at ... the insulin pump segment is expected to witness the ...
(Date:5/25/2016)... 25, 2016 Inivata, a ... of circulating tumour DNA (ctDNA) analysis to improve ... of Professor Clive Morris as Chief ... the clinical development programme, scientific collaborations, and through ... significant improvements in clinical outcomes for patients. ...
(Date:5/24/2016)...   , Study met both ... in , Excellent plus Good ... of the ascending colon   ,      ... announced new positive data from the phase III MORA study for ... litre PEG with ascorbate. The study met both primary endpoints showing ...
Breaking Medicine Technology: