Navigation Links
Omega-3 Fatty Acids Won't Prevent Crohn's Relapse
Date:4/8/2008

Despite earlier promise from small trial, new study finds no effect

TUESDAY, April 8 (HealthDay News) -- Omega-3 free fatty acids don't help prevent relapses in patients with Crohn's disease, concluded two studies published in the April 9 issue of the Journal of the American Medical Association.

"These studies are quite definitive," said study lead author Dr. Brian Feagan, professor of medicine and director of Robarts Clinical Trials at the Robarts Research Institute, University of Western Ontario in London, Ontario, Canada. "The bottom line is, if you're looking to prevent a relapse of Crohn's disease, these are not effective and there are other drugs that work."

Other experts, however, wondered if the dosing used in the study had anything to do with it.

"Maybe there's a perfect dose and maybe this one was too high," said Dr. Timothy Pfanner, assistant professor of internal medicine at Texas A&M Health Science Center College of Medicine and a gastroenterologist with Scott & White. "There are a bunch of medications we use now in Crohn's disease that when you start going high, there's either no benefit or a diminishment of response."

Crohn's disease involves an inflammation of the gastrointestinal tract that most often affects the lower part of the small intestine. Swelling leads to pain and diarrhea. The disease can go into periodic remission but relapses can occur.

Although there are drugs available to help prevent relapse, there is still a need for safe and effective medications. "The drugs we use now, the toxicity can be pretty high," Pfanner said. "You add one more thing on and someone can get critically ill and it's not from the Crohn's disease."

Omega-3 free fatty acids are anti-inflammatory substances found in oily cold-water fish such as salmon, mackerel, herring and sardines. They are used to treat inflammatory disorders such as rheumatoid arthritis.

One small study, involving only 78 patients, was published previously in the New England Journal of Medicine and found a 33 percent reduction in the risk of relapse in Crohn's patients taking omega-3 free fatty acids daily. Another trial, however, found no effect.

Perhaps based on the promising results of the New England Journal trial, many people with Crohn's disease began taking omega-3 free fatty acids in the hopes of preventing a relapse.

But do the supplements really work? To test that out, Feagan and his colleagues conducted two similar trials.

For the first trial, known as EPIC-1 (Epanova Program in Crohn's Study), 363 patients in remission with Crohn's disease were randomly assigned to receive either four grams per day of omega-3 fatty acids or a placebo.

The second trial, EPIC-2, involved 375 patients who were also taking either the drugs prednisone or budesonide for their Crohn's.

Participants in the treatment arm of the trials took the supplements for up to 58 weeks.

The result: Rates of relapse (as measured by a Crohn's Disease Activity Index) scores were roughly the same in all groups, the researchers found.

There is some evidence that omega-3 free fatty acids are helpful in reducing the risk for heart disease. "It's attractive in that there's no evidence that omega-3 free fatty acids are harmful," Feagan said.

But according to the researchers, the message for Crohn's sufferers is clear: other, proven medications are a better bet for preventing relapse.

More information

There's more on Crohn's disease at the U.S. National Institute of Diabetes and Digestive and Kidney Diseases.



SOURCES: Brian G. Feagan, M.D., professor, medicine, and director of Robarts Clinical Trials at Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Timothy Pfanner, M.D., assistant professor, internal medicine, Texas A&M Health Science Center College of Medicine, and gastroenterologist, Scott & White; April 9, 2008, Journal of the American Medical Association


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Dogs and Cats Need Omega-3 Fatty Acids Just as Humans Do - Nordic Naturals Offers Premium Fish Oil to Supplement Pets Diet!
2. Omega-3 Fatty Acids Protect the Spinal Cord, Heart, Brain and Eyes
3. Infant formula must contain DHA omega-3 and AA omega-6, say international experts
4. Mayo Clinic proceedings highlights research about cardiovascular benefits of omega-3 fatty acids
5. Ongoing Tests Show Kona Kampachi(R) is Rich in Omega-3s With No Detectable Mercury
6. Nordic Naturals Professional Exclusive Division Redefines High Potency Omega-3 Supplementation With New Elite Line!
7. Omega-3s Linked to Prevention of Parkinsons Disease and More
8. Maine Natural Health Company Brings Omega-3 Benefits to Pets
9. Brain, Eye and Heart Health: Three Reasons to Eat More Omega-3s
10. Omega-3s Guard Against Type 1 Diabetes
11. Drops of Fatty Acid Curb Symptoms of Dry Eye Syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Omega-3 Fatty Acids Won't Prevent Crohn's Relapse
(Date:3/24/2017)... ... ... Texas Physical Therapy Specialists (TexPTS) is pleased to announce the opening ... is the group’s 7th location in San Antonio and 23rd in Texas. Dr. ... from the clinic, which opened March 22, 2017. , The team of ...
(Date:3/24/2017)... Pittsburgh, PA (PRWEB) , ... March 24, 2017 ... ... the Oncology Nursing Society (ONS) wanted to create a communications platform that positions ... realize this goal, Elliance and ONS reinvented their online publication as an always-on, ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... ( http://www.hygieacare.com ) announced their partnership to prep patients for colonoscopy at the ... Endoscopy Centers in 87th Ave., Miami, FL. , The HyGIeaCare® Prep, ...
(Date:3/24/2017)... ... ... “Vintage and Harvest A Cultivation of Christian Love” is the creation of published author, ... his wife, Anna Marie. He and his wife are the proud parents of four ... of “Shadow and Substance.” , “Love, the agape kind, is seen as more than ...
(Date:3/23/2017)... ... 2017 , ... The physicians of KSF Orthopaedic Center PA are proud to ... location is located at 2255 E. Mossy Oaks Rd., Suite 440, Spring, Texas 77389 ... provide patients living in the north Houston area (The Woodlands, Conroe, Magnolia, Kingwood, Humble) ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Today Stock-Callers.com have issued research reports on four ... NVCN), Hologic Inc. (NASDAQ: HOLX), Edwards Lifesciences Corp. (NYSE: EW), ... companies are part of the Healthcare sector, which gave back ... , 2017, with the NYSE Health Care Index declining 0.2% ... the S&P 500 were down about 0.4% as a group. ...
(Date:3/24/2017)... 2017  GenomeDx Biosciences today announced that six abstracts ... Prostate Cancer Classifier tests will be presented at the ... Congress held March 24 to 28, 2017 in ... is Europe,s largest urological event ... urological field. The abstract titled "Muscle invasive ...
(Date:3/24/2017)...  HealthMine surveys with 9,250 insured consumers fielded from ... members want help from their plans in five key ... health, 2) help closing gaps in care, 3) better ... 5) relevant, real-time guidance. Meeting these needs is essential ... A Reason to Stay Engaged in ...
Breaking Medicine Technology: