Navigation Links
Omega-3 Fatty Acids Guard Against Advanced Prostate Cancer
Date:3/24/2009

Even men genetically predisposed to disease benefit from eating fish, study finds

TUESDAY, March 24 (HealthDay News) -- Omega-3 fatty acids could help protect men against advanced prostate cancer, researchers report.

Eating fish at least once a week may reduce the risk of developing advanced prostate cancer even if one is genetically predisposed to developing the disease, but more work is needed to see if the association is real, the researchers said.

"Eating a healthy diet that includes dark fish and other sources of long-chain omega-3 fatty acids may decrease risk of more advanced prostate cancer even if one has a cox-2 genetic predisposition to the disease," said lead researcher John S. Witte, a professor in the Institute for Human Genetics, Epidemiology & Biostatistics at the University of California, San Francisco.

The report is published in the April issue of Clinical Cancer Research.

For the study, Witte's team studied 466 men with aggressive prostate cancer and 478 healthy men. The researchers collected data on the men's diet and genetically assessed nine cox-2 single nucleotide polymorphisms.

"We detected strong protective associations between increasing intake of long-chain omega-3 polyunsaturated fatty acids and more advanced prostate cancer," Witte said. "These fatty acids are primarily from dark fish such as salmon."

This association held even if men had a high-risk genetic variant in the cox-2 gene, Witte said. "In contrast, men with low intake of dark fish and the high-risk variant had a substantially increased risk of more advanced prostate cancer," he noted.

The researchers found that men who had the highest intake of omega-3 fatty acids had a 63 percent lower risk of aggressive prostate cancer compared with men with the lowest intake of omega-3 fatty acids.

Then the researchers looked at the effect of omega-3 fatty acid in men with a cox-2 variant called rs4647310, a known inflammatory gene. Among men with low omega-3 fatty acid intake and this variant, the risk of developing advanced prostate cancer increased fivefold. However, men who had a high intake of omega-3 fatty acids had a significantly lower risk, even if they had the cox-2 variant.

These findings suggest that eating fish or other sources of long-chain omega-3 polyunsaturated fatty acids may decrease a man's risk of being diagnosed with more advanced prostate cancer, Witte said. "And the decrease in risk may be even more pronounced if one has a high-risk genetic variant in the cox-2 gene."

Focusing on more advanced tumors is important, since these tumors are most likely to take an aggressive course and thus impact a man's survival, he added. "Moreover, our results further support the hypothesis that long-chain omega-3 polyunsaturated fatty acids may modify prostate inflammation through the cyclooxygenase (cox) pathway," Witte said.

Eric Jacobs, strategic director of pharmacoepidemiology at the American Cancer Society, thinks the jury is still out on connecting omega-3 fatty acids with a reduced risk of advanced prostate cancer.

"In this study, a diet high in long-chain omega-3 fatty acids was associated with lower risk of developing advanced prostate cancer," Jacobs said. "However, some previous studies did not find similar results."

Indeed, other research has proved fruitless when it comes to using supplements to help prevent prostate cancer. Two studies released in January in the Journal of the American Medical Association found no evidence of benefit from supplemental selenium, vitamin E or vitamin C on prostate cancer and other cancers. Other recent studies have suggested that vitamins, B, C, D, E, folic acid and calcium taken alone, or in various combinations, aren't effective for cancer prevention either.

Nevertheless, more research into omega-3s role in prostate cancer prevention is needed, Jacobs said.

"One way men can reduce their risk of developing advanced prostate cancer, as well as risk of many other diseases, is to maintain a healthy weight. Many studies have shown that being obese is associated with increased risk of developing advanced prostate cancer," he said.

More information

For more about prostate cancer, visit the American Cancer Society.



SOURCES: John S. Witte, Ph.D., professor, Institute for Human Genetics, Epidemiology & Biostatistics, University of California, San Francisco; Eric Jacobs, Ph.D., strategic director, pharmacoepidemiology, American Cancer Society, Atlanta; April 2009, Clinical Cancer Research


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Omega-3 fatty acids reduce risk of advanced prostate cancer
2. North American Children are Omega-3 Deficient and may be at risk for Suboptimal Health
3. Dr. William Sears and Ocean Nutrition take flight on American Airlines to Spread Consumer Awareness of the Health Benefits of Omega-3 EPA/DHA
4. Nordic Naturals Becomes the Official Omega-3 of the American Pregnancy Association
5. Omega-3s ease depressive symptoms related to menopause
6. Omega-3 Fatty Acid May Help Preemie Girls Brains
7. Three Times More Powerful Than Fish Oil, MegaRed(TM) Omega-3 Krill Oil Now Available Nationwide
8. Fishing for Opportunities in the Omega-3 Ingredients Market
9. Coromega Unveils New Healthy Heart and CoQ10 Supplements : Revolutionary Omega-3 Supplement Company Introduces Two Fresh Takes on Heart Health and Antioxidants
10. NaturalNews Partners with Moxxor to Bring Marine Omega-3 Supplement to Health-Conscious Consumers
11. Ocean Nutrition Canada Limited Secures Their Position as the Largest Omega-3 EPA/DHA Ingredient Supplier in the World
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Omega-3 Fatty Acids Guard Against Advanced Prostate Cancer
(Date:6/27/2016)... California (PRWEB) , ... June 27, 2016 , ... "FCPX ... fully customizable inside of Final Cut Pro X," said Christina Austin - CEO of ... unique style. Final Cut Pro X users can now reveal the media ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... technology to revolutionize the emergency ambulance transport experience for the millions of people ... how Uber has disrupted the taxi industry through the use of technology. Now, ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever ... Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation ... as home to some of the world’s leading providers of cereal and other breakfast ...
(Date:6/26/2016)... ... ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a weight ... app plans to fix the two major problems leading the fitness industry today:, ... program , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Market - Forecast to 2022" report to their offering. ... method for the patients with kidney failure, it replaces the ... from the patient,s blood and thus the treatment helps to ... chloride in balance. Increasing number of ESRD ...
Breaking Medicine Technology: