Navigation Links
Omega-3 Fatty Acids Guard Against Advanced Prostate Cancer
Date:3/24/2009

Even men genetically predisposed to disease benefit from eating fish, study finds

TUESDAY, March 24 (HealthDay News) -- Omega-3 fatty acids could help protect men against advanced prostate cancer, researchers report.

Eating fish at least once a week may reduce the risk of developing advanced prostate cancer even if one is genetically predisposed to developing the disease, but more work is needed to see if the association is real, the researchers said.

"Eating a healthy diet that includes dark fish and other sources of long-chain omega-3 fatty acids may decrease risk of more advanced prostate cancer even if one has a cox-2 genetic predisposition to the disease," said lead researcher John S. Witte, a professor in the Institute for Human Genetics, Epidemiology & Biostatistics at the University of California, San Francisco.

The report is published in the April issue of Clinical Cancer Research.

For the study, Witte's team studied 466 men with aggressive prostate cancer and 478 healthy men. The researchers collected data on the men's diet and genetically assessed nine cox-2 single nucleotide polymorphisms.

"We detected strong protective associations between increasing intake of long-chain omega-3 polyunsaturated fatty acids and more advanced prostate cancer," Witte said. "These fatty acids are primarily from dark fish such as salmon."

This association held even if men had a high-risk genetic variant in the cox-2 gene, Witte said. "In contrast, men with low intake of dark fish and the high-risk variant had a substantially increased risk of more advanced prostate cancer," he noted.

The researchers found that men who had the highest intake of omega-3 fatty acids had a 63 percent lower risk of aggressive prostate cancer compared with men with the lowest intake of omega-3 fatty acids.

Then the researchers looked at the effect of omega-3 fatty acid in men with a cox-2 variant called rs4647310, a known inflammatory gene. Among men with low omega-3 fatty acid intake and this variant, the risk of developing advanced prostate cancer increased fivefold. However, men who had a high intake of omega-3 fatty acids had a significantly lower risk, even if they had the cox-2 variant.

These findings suggest that eating fish or other sources of long-chain omega-3 polyunsaturated fatty acids may decrease a man's risk of being diagnosed with more advanced prostate cancer, Witte said. "And the decrease in risk may be even more pronounced if one has a high-risk genetic variant in the cox-2 gene."

Focusing on more advanced tumors is important, since these tumors are most likely to take an aggressive course and thus impact a man's survival, he added. "Moreover, our results further support the hypothesis that long-chain omega-3 polyunsaturated fatty acids may modify prostate inflammation through the cyclooxygenase (cox) pathway," Witte said.

Eric Jacobs, strategic director of pharmacoepidemiology at the American Cancer Society, thinks the jury is still out on connecting omega-3 fatty acids with a reduced risk of advanced prostate cancer.

"In this study, a diet high in long-chain omega-3 fatty acids was associated with lower risk of developing advanced prostate cancer," Jacobs said. "However, some previous studies did not find similar results."

Indeed, other research has proved fruitless when it comes to using supplements to help prevent prostate cancer. Two studies released in January in the Journal of the American Medical Association found no evidence of benefit from supplemental selenium, vitamin E or vitamin C on prostate cancer and other cancers. Other recent studies have suggested that vitamins, B, C, D, E, folic acid and calcium taken alone, or in various combinations, aren't effective for cancer prevention either.

Nevertheless, more research into omega-3s role in prostate cancer prevention is needed, Jacobs said.

"One way men can reduce their risk of developing advanced prostate cancer, as well as risk of many other diseases, is to maintain a healthy weight. Many studies have shown that being obese is associated with increased risk of developing advanced prostate cancer," he said.

More information

For more about prostate cancer, visit the American Cancer Society.



SOURCES: John S. Witte, Ph.D., professor, Institute for Human Genetics, Epidemiology & Biostatistics, University of California, San Francisco; Eric Jacobs, Ph.D., strategic director, pharmacoepidemiology, American Cancer Society, Atlanta; April 2009, Clinical Cancer Research


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Omega-3 fatty acids reduce risk of advanced prostate cancer
2. North American Children are Omega-3 Deficient and may be at risk for Suboptimal Health
3. Dr. William Sears and Ocean Nutrition take flight on American Airlines to Spread Consumer Awareness of the Health Benefits of Omega-3 EPA/DHA
4. Nordic Naturals Becomes the Official Omega-3 of the American Pregnancy Association
5. Omega-3s ease depressive symptoms related to menopause
6. Omega-3 Fatty Acid May Help Preemie Girls Brains
7. Three Times More Powerful Than Fish Oil, MegaRed(TM) Omega-3 Krill Oil Now Available Nationwide
8. Fishing for Opportunities in the Omega-3 Ingredients Market
9. Coromega Unveils New Healthy Heart and CoQ10 Supplements : Revolutionary Omega-3 Supplement Company Introduces Two Fresh Takes on Heart Health and Antioxidants
10. NaturalNews Partners with Moxxor to Bring Marine Omega-3 Supplement to Health-Conscious Consumers
11. Ocean Nutrition Canada Limited Secures Their Position as the Largest Omega-3 EPA/DHA Ingredient Supplier in the World
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Omega-3 Fatty Acids Guard Against Advanced Prostate Cancer
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned by ... to enhance the health of felines. The formula is all-natural and is made from ... the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can ... Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey ... cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under ...
(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Dublin ... of the " Global Markets for Spectroscopy Equipment" ... This report focuses on the global ... including its applications in various applications. The report deals ... three main industries: pharmaceutical and biotechnology, food and beverage, ...
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
Breaking Medicine Technology: