Navigation Links
Older age memory loss tied to stress hormone receptor in brain
Date:4/6/2011

Scientists have shed new light on how older people may lose their memory with a development that could aid research into treatments for age-related memory disorders.

Many believe that stress is bad for our brains especially as we get older. Now researchers have shown how two receptors in older brains react to a stress hormone called cortisol, which has been linked to increasing forgetfulness as we age.

The study, by the University of Edinburgh, found that one receptor was activated by low levels of cortisol, which helped memory.

However, once levels of this stress hormone were too high they spilled over onto a second receptor activating brain processes that contribute to memory impairment.

The study, published in the leading Journal of Neuroscience, found that high levels of the stress hormone in aged mice made them less able to remember how to navigate a maze.

The memory recall problem was reversed when the receptor linked to poor memory was blocked.

The research helps explain why too much stress over a prolonged period interferes with the normal processes in storing everyday memories despite the fact that a little bit of stress can help us better remember emotional memories.

Dr Joyce Yau, at the University's Centre for Cardiovascular Science, who led the study, said: "While we know that stress hormones affect memory, this research explains how the receptors they engage with can switch good memory to poorly-functioning memory in old age. We now know that lowering the levels of these stress hormones will prevent them from activating a receptor in the brain that is bad for memory. Understanding the mechanisms in the brain, which affect memory as we age, will help us to find ways to combat conditions linked to memory loss."

The study was funded by the Medical Research Council.

Professor Chris Kennard, Chairman of the MRC's Neuroscience and Mental Health Board said: "This research highlights some interesting, original concepts relating to why memory loss occurs in old age. With people living ever longer, the MRC is really focussing on research which allows elderly people not just to survive, but also to stay healthy."

The researchers are currently investigating a new chemical compound which blocks an enzyme 11beta-HSD1 that is involved in producing stress hormones within cells, supported by a Seeding Drug Discovery Award from the Wellcome Trust. They hope this could be used to develop a drug treatment to slow the normal decline in memory associated with ageing or even improve memory in the already very old.


'/>"/>

Contact: Tara Womersley
tara.womersley@ed.ac.uk
44-131-650-9836
University of Edinburgh
Source:Eurekalert

Related medicine news :

1. Watch your step: Elevator-related injuries and older adults
2. California IVF Discount/Rebate Program Eases Risk for Older Mothers
3. Diabetes drug ups risk for bone fractures in older women
4. Autism Science Foundation Offers IMFAR Grants to Autism Stakeholders
5. Americans Recognize Risk of Fire to Older Adults
6. Key Pillars of Patient Centered Medical Home Will Be Focus of March 30 Patient-Centered Primary Care Collaborative Stakeholders Meeting
7. Kidneys From Older Donors Suitable for Seniors
8. Screens, Vaccine for HPV Less Beneficial in Older Women
9. Tyco International to Host 2010 Annual General Meeting of Shareholders
10. Midlife crisis: Unmarried older women twice as likely to lack health insurance, study shows
11. New clues found linking larger animals to colder climates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... May 28, 2016 , ... May 26, 2016- In ... Arts Fighting Challenge with theme event of “K Warriors” on June 4, 2016 at ... , The event is sponsored and hosted by Shaolin Institute and sanctioned by ...
(Date:5/27/2016)... ... 27, 2016 , ... Two director-level employees of Horizon Blue Cross Blue Shield ... (TWIN) 2016 honorees. The award recognizes businesswomen who excel in their fields and ... of the MLTSS (Managed Long-Term Services and Supports) Program at Horizon NJ Health and ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... ... casual readers, this installment is bolstered by inspiring human-interest stories, courtesy of awareness-driven ... tech within the industry, from leading advocates, associations and industry leaders such as ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... in scholarships to students studying complementary medicine. Allison Outerbridge is this year’s ... her award on May 18 at the university’s Student Leadership Awards ceremony. , ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cabot Corporation, Pfizer, and 3M ... to court documents and SEC filings. A jury has returned a verdict ... Optical Corporation, Case No. BC588866, Los Angeles County, California. The jury awarded $22.8 ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... YORK , May 27, 2016 ... biotechs, drug manufacturers, health insurance companies all falling under ... small healthcare companies. While not often talked about, these ... The United States is by far ... world. Advanced Medical Isotope Corp. (OTC: ADMD), Nutranomics Inc. ...
(Date:5/26/2016)... -- TARE (Transarterial Radio-embolization) Using Yttrium-90 ... Overall Decreased Use of Hospital Resource ... healthcare company, has today announced the publication of ... ISPOR (International Society for Pharmacoeconomics and Outcomes Research), ... yttrium-90 glass microspheres is associated with cost savings ...
(Date:5/25/2016)... , May 25,2016 ... the near-infrared Cellvizio platform for urological and surgical ... OTCQX: MKEAY) inventor of Cellvizio®, the multidisciplinary confocal ... regulatory milestone in the US with the 12 ... and Drug Administration (FDA). This new FDA clearance ...
Breaking Medicine Technology: