Navigation Links
Older adults often excluded from clinical trials
Date:2/2/2011

Older individuals, who constitute a rapidly growing population in the United States, account for a disproportionate share of health care utilization and cost.

Yet more than half of clinical trials exclude people based on their age or age-related conditions, according to a new study by Robert Wood Johnson Foundation (RWJF) Clinical Scholars at the University of Michigan.

"These findings are concerning because it means that doctors cannot be confident that clinical trial results apply to their older patients," says Donna Zulman, M.D., the study's lead author and a Veterans Affairs scholar with the RWJF Clinical Scholars program at the University of Michigan Health System. "Health care providers and patients need better evidence about treatment strategies that improve the health and quality of life of seniors."

As of 2009, Americans over the age of 65 represented 12.5 percent of the U.S. populationabout one in every eight Americansand by 2030, that number is expected to almost double.

This population accounts for 34 percent of personal health care expenditures, with the majority of spending attributed to individuals with chronic diseases.

Yet in a review of clinical trials published in major medical journals, Zulman and her colleagues found that one in five trials excluded patients based on their age alone. Furthermore, almost half of the remaining trials excluded individuals using criteria that could disproportionately impact older adults, such as physical frailty or impaired cognition.

The study also found that trials rarely assess how treatments affect function and quality of life, outcomes that are often of great importance to older individuals.

"These practices leave health care providers in the dark when determining which treatment will best serve the needs of their patients," says Zulman.

"It is rarely appropriate to exclude people from clinical trials based on their age alone," argues Jeremy B. Sussman, M.D., a study co-author and a Veterans Affairs scholar with the RWJF Clinical Scholars program at the U-M. "This is especially true in trials investigating conditions that are common in older adults."

The study authors suggest that clinical trial evidence guiding treatment of older adults would be improved by eliminating upper age limits for study inclusion, by reducing the use of eligibility criteria that disproportionately affect older patients, and by encouraging adherence to recommended analytical methods for evaluating treatment effects by age.

"There's a critical need to ensure that research findings are relevant for our most complex and vulnerable older patients," says Zulman. "Our findings suggest a need for policy change by government agencies like the Food and Drug Administration and the National Institutes of Health to increase the representation of typical older adults in clinical trials."


'/>"/>

Contact: Shantell M. Kirkendoll
smkirk@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. Watch your step: Elevator-related injuries and older adults
2. California IVF Discount/Rebate Program Eases Risk for Older Mothers
3. Diabetes drug ups risk for bone fractures in older women
4. Autism Science Foundation Offers IMFAR Grants to Autism Stakeholders
5. Americans Recognize Risk of Fire to Older Adults
6. Key Pillars of Patient Centered Medical Home Will Be Focus of March 30 Patient-Centered Primary Care Collaborative Stakeholders Meeting
7. Kidneys From Older Donors Suitable for Seniors
8. Screens, Vaccine for HPV Less Beneficial in Older Women
9. Tyco International to Host 2010 Annual General Meeting of Shareholders
10. Midlife crisis: Unmarried older women twice as likely to lack health insurance, study shows
11. New clues found linking larger animals to colder climates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... The Muscular ... Louisiana Kitchen restaurants, launched the 14th annual “Appetite for a Cure” campaign on ... muscular dystrophy, ALS and related diseases that severely limit strength and mobility. ...
(Date:2/5/2016)... Toronto, Ontario (PRWEB) , ... February 05, 2016 , ... ... the Scarborough General Hospital Burn Unit, plastic and cosmetic surgeon Dr. Wayne Carman transitioned ... the Scarborough Hospital. He successfully completed his first three-year term as chief and began ...
(Date:2/5/2016)... ... ... The American public tends to feel uncomfortable about drinking recycled waste water ... well water. The recent experience with lead contaminated water in Flint, Michigan, according to ... increasing public acceptance of recycled waste water as drinking water. , The Flint ...
(Date:2/5/2016)... Seattle, WA (PRWEB) , ... February 05, 2016 ... ... consulting firm, ranked #3 in the 2015 Best in KLAS: Software & Services ... The annual Best in KLAS report independently ranks vendor performance by healthcare ...
(Date:2/5/2016)... , ... February 05, 2016 , ... ... of CitiDent, announces that it is now welcoming orthodontist, Dr. Amanda Cheng, ... offers a complete range of oral health care, including general dentistry, cosmetic treatments, ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... Ind. , Feb. 5, 2016  Zimmer Biomet ... pricing of the previously announced underwritten secondary offering of ... its stockholders, consisting of affiliates of Blackstone and Goldman ... at an initial price of $96.45 per share. The ... the offering.  Neither Zimmer Biomet nor any of its ...
(Date:2/5/2016)... Site Profile: --> ... Recognition People, announced their latest primary healthcare case study where speech ... times and to save the practice money. Site Profile: ... Challenge: --> ,- Wirral CCG ,- VoicePower client ... ,- Wirral CCG ,- VoicePower client since 2013 Challenge: ...
(Date:2/4/2016)... , Feb. 4, 2016 For hospitals ... or those already participating in the program, the Health ... referred to as the , Mega-Guidance , could have ... guidance is published in September 2016. Essential ... and Service Marketing , summarizes the Mega-Guidance,s key proposed ...
Breaking Medicine Technology: