Navigation Links
Older Drug Effective in Treating Pediatric Nerve Cancer
Date:1/20/2009

Low, short-term doses of DFMO helps prevent disease spread, study finds

TUESDAY, Jan. 20 (HealthDay News) -- An anti-cancer drug shelved because it was thought to be too toxic may be effective in small doses against a devastating pediatric cancer, a new study found.

In tests on animal models, the drug a-difluoromethylornithine, or DFMO, helped prevent the spread of neuroblastoma, a cancer of the nervous system responsible for 15 percent of all pediatric deaths related to cancer.

"The drug, which was developed as a cancer therapy and later shelved because of toxicity concerns, has been around since the 1970s," John Cleveland, chair of the Scripps Florida department of cancer biology, whose laboratory conducted the study, said in a news release issued by the institution. "But over the past five years, it has undergone a rebirth as a chemoprevention agent, first showing efficacy in animal models of human cancer and, more recently, in human prostate and colon cancer. Our study shows that it likely works in a large cast of tumors, even those having poor prognosis, like high-risk neuroblastoma."

In the study, published in the Jan. 15 issue of Cancer Research, researchers successfully used DFMO to target ornithine decarboxylase (Odc), a protein that aids in cancer cell growth and has been found in abundance in neuroblastoma with a poor prognosis, to prevent neuroblastoma in genetically altered mice.

"What's even more compelling, we used low doses of the drug, and DFMO only had to be given for a moderate amount of time to prevent cancer," Cleveland said of the study.

Neuroblastoma usually occurs in infants and young children. Those with stage IV, high-risk neuroblastoma have a less than a 40 percent chance of long-term survival.

More information

The U.S. National Cancer Institute has more about

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Older Women Get Fewer Kidney Transplants Than Men
2. Contrary to Earlier Predictions, Older Driver Fatal Crashes Trend Down
3. BD Announces Webcast of Annual Meeting of Shareholders
4. 2009: The Year of Health Care Reform? Faith-Based Investors See Doubling of Related Shareholder Resolutions, Growing Public Support From Corporate America
5. Shareholders of Med-Emerg International Inc. approve plan of arrangement with AIM Health Group Inc.
6. A life with pain -- new study examines the experiences of older people
7. Implanted Defibrillators Benefit Older People
8. Vision problems prompt older drivers to put down the keys
9. LCA-Vision Urges Stockholders to Take No Action Regarding the Joffe Groups Threatened Consent Solicitation
10. Rural/Metro Employee Shareholders Voice Concerns At Companys Annual Meeting
11. Stakeholders and public should use 20 specific health indicators
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Older Drug Effective in Treating Pediatric Nerve Cancer 
(Date:8/20/2014)... (PRWEB) August 20, 2014 Locating rates for ... of the Quotes Pros website. A new source of term ... and review rates good for all 50 states at ... is one of the new methods available for the public ... packages that are supplied. The instant quotations that are available ...
(Date:8/20/2014)... Thompson HealthDay Reporter WEDNESDAY, ... has saved a group of rhesus monkeys from deadly Marburg ... up to 90 percent of those it infects, researchers report. ... of Marburg virus, even when it was given three days ... the journal Science Translational Medicine . This is ...
(Date:8/20/2014)... An imaging study of chronic users of codeine-containing ... regions of brain white matter and associates these ... , Researchers used diffusuion tensor imaging (DTI) (an ... investigate the white matter integrity of chronic CCS ... the brain, including the inferior fronto-occipital fasciculus, which ...
(Date:8/20/2014)... Barbara Bronson Gray HealthDay Reporter ... extremely rare, colds, flu and other minor infections might ... stroke in children, a new study suggests. Just five ... the United States, said Dr. Heather Fullerton, lead author of ... the University of California, San Francisco Benioff Children,s Hospital. "It ...
(Date:8/20/2014)... HealthDay Reporter WEDNESDAY, Aug. 20, 2014 (HealthDay ... an option, but a new study shows that only about ... reasons women didn,t undergo reconstruction was that they felt it ... were focused on their cancer treatment," said lead researcher Dr. ... Cancer Center, in New York City. Also common was ...
Breaking Medicine News(10 mins):Health News:Term Life Insurance Price Database Now Helps Quote Prices for Adults in 50 States Online 2Health News:Drug for Ebola-Like Virus Shows Promise in Monkeys 2Health News:Drug for Ebola-Like Virus Shows Promise in Monkeys 3Health News:Study Ties Colds, Flu to Rare Risk of Stroke in Kids 2Health News:Study Ties Colds, Flu to Rare Risk of Stroke in Kids 3Health News:Many Women Who Have Mastectomy Don't Get Breast Reconstruction: Study 2Health News:Many Women Who Have Mastectomy Don't Get Breast Reconstruction: Study 3
... effect on someones physical health? This question is debated ... the latest Medical Journal of Australia. ,Spirituality ... spirituality in health, its relevance to Australian practitioners and ... and the current gaps where more research is needed. ...
... is needed to reduce the risk of diabetes in ... ,A study by Dr Robyn McDermott, Pro-vice Chancellor of ... South Australia, shows that while clinical care of adults ... the disease. ,The results, published in ...
... enough changes in the brain to sensitize people to ... , even in people who dont have a stress-related ... high-intensity traumas can have long lasting effects on the ... current clinical disorder. But these subtle changes could increase ...
... Q10 appear to increase blood levels of this ... , but does not improve Parkinsons disease ... is a neurodegenerative disorder characterized by tremors and ... mechanisms underlying the condition are not fully understood, ...
... has called upon the media to take message of environmental ... personal lives . ,Actoptrnot hit back at accusations ... and narrated at the Cannes film festival. ,Asked ... taken a fuel-guzzling jet on his way to the French ...
... that dissolves in the mouth like a popular breath-freshener ... impoverished areas. The innovative drug-delivery system was developed ... ,During a two-semester course, the seven-student team fabricated a ... mouth, prompting the child to swallow the vaccine. The ...
Cached Medicine News:Health News:Trauma Exposure can Affect Brain Function Several Years After Event 2Health News:Coenzyme Q10 Does Not Improve Parkinsons Disease Symptoms 2Health News:DiCaprio Bites Back Over Eco 'Hypocrisy' 2Health News:Students Devise Oral Quick-dissolve Strips for Rotavirus Vaccine 2Health News:Students Devise Oral Quick-dissolve Strips for Rotavirus Vaccine 3
(Date:8/20/2014)... Md. , Aug. 20, 2014  The ... lauded the latest results achieved by the real-time, ... as the National Precursor Log Exchange (NPLEx), automatically ... officials track down methamphetamine offenders and make arrests. ... Missouri blocked the sale ...
(Date:8/20/2014)... , Aug. 20, 2014 /PRNewswire/ ... market research report is available in ... for Hospital-Acquired Infection Control (Sterilization, Disinfection, ... http://www.reportlinker.com/p01618925/The-Market-for-Hospital-Acquired-Infection-Control-Sterilization-Disinfection-Testing-and-Treatment.html Given ... infections (HAIs), demand has increased for ...
(Date:8/20/2014)... 2014 Reportlinker.com announces that a ... its catalogue: Personal Accident and ... Opportunities to 2017 ... report provides in depth market analysis, information ... and health insurance segment, including: • The ...
Breaking Medicine Technology:Missouri's Stop-Sale System Achieves Significant Results In Battle Against Meth 2The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 2The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 3The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 4The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 5The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 6Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 2Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 3Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 4Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 5Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 6Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 7Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 8Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 9Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 10Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 11Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 12Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 13Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 14Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 15Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 16Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 17Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 18Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 19Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 20Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 21Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 22Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 23
... SHANGHAI , Aug. 3 /PRNewswire-Asia/ -- Sangon ... company, and Bio Basic Inc. (BBI), a Toronto ... completion of,a $10 million round of funding ... scale research & development, marketing and sales of its ...
... Aug. 3 /PRNewswire-Asia-FirstCall/ -- Concord Medical Services,Holdings Limited ... of the largest,network of radiotherapy and diagnostic imaging centers in ... for the second,quarter ended June 30, 2010 , before ... Medical,s management will hold an earnings conference call at ...
Cached Medicine Technology:Sangon & Bio Basic Inc. Closes $10 Million Round of Investment by Qiming Ventures 2Sangon & Bio Basic Inc. Closes $10 Million Round of Investment by Qiming Ventures 3Concord Medical to Report Second Quarter 2010 Financial Results on Wednesday, August 18, 2010 2Concord Medical to Report Second Quarter 2010 Financial Results on Wednesday, August 18, 2010 3
... Extremely accurate detections of ... well as glaucoma in ... be performed. Smooth operation ... perimetry. High accuracy of ...
... Analyzer II-i series is a wheelchair accessible, ... visual field. By using SitaTM, the expert ... by up to 70%. A patented aspherically ... to increase patient comfort while testing out ...
... Tailor Made Toric soft contact lenses let you ... other soft toric lens in a lens custom ... of comfort is made possible by PC Technology™, ... phosphorylcholine (PC), a substance found naturally in human ...
Frequency 55 Toric XR is a great option for those with high levels of astigmatism...
Medicine Products: