Navigation Links
Older Antidepressant May Treat Heart Failure
Date:1/8/2010

The drug clorgyline shows promise in animal tests, but side effects concern researchers

FRIDAY, Jan. 8 (HealthDay News) -- An older antidepressant that's no longer prescribed may find new life as an effective heart failure treatment, research suggests.

The drug, known as clorgyline, hasn't been tested in humans as a heart-failure medication, but research in animals has found it can reduce and even reverse the symptoms of heart failure, including enlargement of the heart and a weakened ability to pump blood through the body.

Researchers reporting their findings in the Jan. 8 issue of Circulation Research say the drug blocks a key enzyme called monoamine oxidase-A. Clorgyline stops the enzyme from breaking down a neurohormone -- norepinephrine -- that controls the pace of the heart's pumping.

"Our study helps describe heart failure as a vicious chemical circle of stimulant norepinephrine overload and breakdown, and it offers a disease blueprint with monoamine oxidase-A as the target for drugs similar to clorgyline to rein in the disease," says senior study investigator and cardiologist Dr. Nazareno Paolocci in a statement. He is an assistant professor at the Johns Hopkins University School of Medicine and at the University of Perugia in Italy.

However, clorgyline also has a variety of side effects, Paolocci said, and people who take it have to avoid a long list of foods. Newer drugs in the same class as clorgyline will have to be tested first, he said.

An estimated 5.7 million American men and women suffer from chronic heart failure. The disorder killed an estimated 290,000 people in 2005.

More information

Learn more about heart failure from the American Heart Association.



-- Randy Dotinga



SOURCE: Johns Hopkins Medicine, news release, Jan. 5, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Ability to cope with stress can increase good cholesterol in older white men, study finds
2. Many Older Americans Have Active Sex Lives
3. Good Cholesterol Wont Help Heavy-Drinking Older Men
4. Manor Care, Inc. Announces Record Date for Special Stockholder Meeting
5. Arrow International Urges Shareholders To Vote for Approval of the $45.50 Teleflex Inc. Merger and for the Current Board of Directors
6. Frequent alcohol consumption increases cancer risk in older women
7. Zimmer Holdings Offer and ORTHOsoft Directors Circular Mailed to Shareholders
8. ISS and Glass Lewis Recommend Cholestech Stockholders Vote FOR Merger
9. Glass Lewis Recommends Arrow Shareholders Vote on the White Proxy Card for Merger With Teleflex and for Current Board of Directors at Arrow Annual Meeting
10. Drug-free treatments offer hope for older people in pain
11. United Medicorp, Inc.s Shareholders Approve All Proposals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2017)... ... June 27, 2017 , ... From June 20-22, EarQ and ... in Syracuse, New York, where EarQ is headquartered. , Together, the organizations educate ... with today’s savvy consumer, and the latest in hearing technology. At the event, ...
(Date:6/27/2017)... ... June 27, 2017 , ... Atmosera , ... Atmosera Managed Azure Services . The trusted, transparent, and secure solution for the ... growing customer base. Atmosera’s next generation services include integrated capabilities for public, private, ...
(Date:6/27/2017)... ... June 27, 2017 , ... A+ Orthodontics is ... specialty that focuses on treating alignment and occlusion irregularities. Treatment often includes the ... , North Hollywood dentist , Dr. Garemani, along with Dr. Reza and ...
(Date:6/26/2017)... ... June 26, 2017 , ... Dr. Martin Bastuba, MD, FACS, ... with the Fertility Center of California, is pleased to announce the addition of ... and TESA (percutaneous testicular sperm extraction). These minimally invasive treatments are primarily used ...
(Date:6/26/2017)... (PRWEB) , ... June 26, 2017 , ... ... coding staff, and consumers are seeing lots of red these days. According to ... inaccurate charges that result from medical coding errors(1). Some studies point to Electronic ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... GAITHERSBURG, Md. , June 7, 2017  Novavax, Inc., ... the second of two Phase 2 trials of its RSV ... women of child bearing age have been published in the ... this publication have been shared in prior scientific conferences). The ... trial in April 2014. Novavax is developing the RSV F ...
(Date:6/2/2017)... 2, 2017  NxStage Medical, Inc. (Nasdaq:  NXTM), a leading medical ... new findings demonstrating positive biochemical outcomes related to more ... The data will be presented at the ERA-EDTA Congress ... Spain . The research was ... Network in Europe (KIHDNEy) ...
(Date:5/29/2017)... AVIV, Israel, May 29, 2017  Cellect Biotechnology Ltd. ... innovative technology which enables the functional selection of stem ... results for the first quarter ended March 31 st ... with our accomplishments in the first quarter of 2017," ... first quarter, we announced the treatment of the first ...
Breaking Medicine Technology: