Navigation Links
Old gastrointestinal drug slows aging, McGill researchers say
Date:1/6/2009

This release is available in French.

Recent animal studies have shown that clioquinol an 80-year old drug once used to treat diarrhea and other gastrointestinal disorders can reverse the progression of Alzheimer's, Parkinson's and Huntington's diseases. Scientists, however, had a variety of theories to attempt to explain how a single compound could have such similar effects on three unrelated neurodegenerative disorders.

Researchers at McGill University have discovered a dramatic possible new answer: According to Dr. Siegfried Hekimi and colleagues at McGill's Department of Biology, clioquinol acts directly on a protein called CLK-1, often informally called "clock-1," and might slow down the aging process. The advance online edition of their study was published in Oct. 2008 in the Journal of Biological Chemistry.

"Clioquinol is a very powerful inhibitor of clock-1," explained Hekimi, McGill's Strathcona Chair of Zoology and Robert Archibald & Catherine Louise Campbell Chair in Developmental Biology. "Because clock-1 affects longevity in invertebrates and mice, and because we're talking about three age-dependent neurodegenerative diseases, we hypothesize that clioquinol affects them by slowing down the rate of aging."

Once commonly prescribed in Europe and Asia for gastrointestinal problems like diarrhea and shigella, clioquinol was withdrawn from the market after being blamed for a devastating outbreak of subacute myelo-optic neuropathy (SMON) in Japan in the 1960s. However, because no rigorous scientific study was conducted at the time, and because clioquinol was used safely by millions before and after the Japanese outbreak, some researchers think its connection to SMON has yet to be proven.

The exact mechanism of how clioquinol inhibits CLK-1 is still under investigation, Hekimi said. "One possibility is that met
'/>"/>

Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Chronic gastrointestinal symptoms in Korean population
2. Strategies for preventing gastrointestinal complications in severely burned patients
3. A new breakthrough in timing of urgent endoscopy for gastrointestinal bleeding patients
4. July 2008 Mayo Clinic Womens HealthSource Highlights Vitamin D, Savvy Use of Sunscreen and Gastrointestinal Upset and Celiac Disease
5. 10th World Congress on Gastrointestinal Cancer -- Barcelona, Spain
6. Protein predicts Gleevec resistance in gastrointestinal tumors
7. ASGE issues updated infection control guidelines for gastrointestinal endoscopy
8. ASGE issues updated guidelines on antibiotic prophylaxis for gastrointestinal endoscopy
9. Which segments of the gastrointestinal tract does Salmonella enteritidis penetrate?
10. The 2008 Gastrointestinal Cancers Symposium
11. Supratek Pharma Inc. announced today that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for SP1049C for the treatment of metastatic adenocarcinoma of the upper gastrointestinal tract
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... CT (PRWEB) July 11, 2014 ... the nation’s only non-profit dedicated exclusively to cell ... that Joshua Corday has joined the organization as ... fundraising professional with deep experience securing gifts and ... served as Annual Giving Director for NewYork Presbyterian ...
(Date:7/11/2014)... Global enterprises today are shifting towards the ... activities. Managed services offer these global enterprises a strategic ... resulted into rising operational costs to companies. The aim ... be the global market driver for expanding the managed ... services market is estimated to grow from $142.75 billion ...
(Date:7/11/2014)... 11, 2014 Presently, disposable medical suppliers ... equipment and supplies segment. During the past two decades, ... growth (on an average 12.5% per year), primarily owing ... Currently, the US is the largest market for disposable ... of 40%. The second position is held by Europe ...
(Date:7/11/2014)... PROVIDENCE, R.I. -- Researchers from The Miriam ... under age 65 have significantly higher rates of ... with mobility impairments were less likely to attempt ... quit-smoking treatments may not be sufficient for this ... online in advance of print in the ...
(Date:7/11/2014)... of its kind has found that organic foods ... their conventional counterparts, including more antioxidants and fewer, ... at an unprecedented 343 peer-reviewed publications comparing the ... plant-based foods, including fruits, vegetables, and grains. The ... differences between organic and non-organic foods. , ...
Breaking Medicine News(10 mins):Health News:Alliance for Cancer Gene Therapy (ACGT) Welcomes Joshua Corday as Senior Development Officer 2Health News:Alliance for Cancer Gene Therapy (ACGT) Welcomes Joshua Corday as Senior Development Officer 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 4Health News:Global Disposable Medical Supplies Market to See Robust Growth Through Next Decade, According to New TriMark Report Available at MarketPublishers.com 2Health News:Global Disposable Medical Supplies Market to See Robust Growth Through Next Decade, According to New TriMark Report Available at MarketPublishers.com 3Health News:Miriam Hospital study examines smoking prevalence 2Health News:Major study documents nutritional and food safety benefits of organic farming 2Health News:Major study documents nutritional and food safety benefits of organic farming 3
... and the elderly have slower response times when they have ... research suggests that much of that slower response is a ... healthy older people can be trained to respond faster in ... cognitive skills in this area aren,t so different from younger ...
... celiac disease -- an autoimmune disorder associated with a ... than the general population to report symptoms of depression ... gluten-free diet, according to researchers at Penn State, Syracuse ... often suffer from abdominal pain, constipation, decreased appetite, diarrhea, ...
... Teens are more likely to be obese if they had ... toddlers, according to a new study. The findings echo ... ties with their parents were more likely to be obese ... the latest study, researchers examined U.S. National Institute of Child ...
... -- Quitting smoking is one of the most common ... with six of 10 smokers requiring multiple attempts before ... Association. However, preparing a quit-smoking plan can greatly ... the single most important step smokers can take to ...
... The quality of the emotional relationship between a mother ... that child to be obese during adolescence, a new ... characteristics between mothers and their children during their toddler ... terms of the child,s emotional security and the mother,s ...
... team of neuroscientists, led by researchers at Mayo Clinic ... brain disorder that may be much more common than once ... Nature Genetics , the researchers say they identified 14 ... of hereditary diffuse leukoencephalopathy with spheroids (HDLS). This ...
Cached Medicine News:Health News:Elderly can be as fast as young in some brain tasks, study shows 2Health News:Elderly can be as fast as young in some brain tasks, study shows 3Health News:Elderly can be as fast as young in some brain tasks, study shows 4Health News:Women with celiac disease suffer from depression, disordered eating 2Health News:Women with celiac disease suffer from depression, disordered eating 3Health News:Mother-Toddler Bond May Influence Teen Obesity 2Health News:How to Make Your Quit-Smoking Resolution Stick 2Health News:Study links quality of mother-toddler relationship to teen obesity 2Health News:Study links quality of mother-toddler relationship to teen obesity 3Health News:Study links quality of mother-toddler relationship to teen obesity 4Health News:'Rare' brain disorder may be more common than thought, say Mayo Clinic scientists 2Health News:'Rare' brain disorder may be more common than thought, say Mayo Clinic scientists 3
(Date:7/10/2014)... BURLINGTON, Mass. , July 10, 2014 /PRNewswire/ ... three-quarters of surveyed infectious disease (ID) specialists are ... Medicines Company,s Orbactiv (oritavancin) for use as OPAT, ... to prescribe these agents to their hospital inpatients. ... percent) of OPAT patients are initiated on OPAT ...
(Date:1/15/2014)... Sono-Tek Corporation (OTC BB: SOTK) today announced sales of  ... to sales of $2,202,000 for the prior year period, an ... also shown growth over the preceding quarter,s sales, continuing a ... year. Markets that experienced sales increases over the prior year ...
(Date:1/15/2014)... Mich. , Jan. 15, 2014 As health officials ... flu virus, select Meijer pharmacies in Michigan ... throat to eligible patients, enabling Meijer pharmacists to administer tests ... protocol set by a physician participating in the study. ...
Breaking Medicine Technology:Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3
... Feb. 21, 2012 ConvaTec, a world-leading developer and ... care, today announces that Ken Berger will assume the ... the ConvaTec Board of Directors. Berger joins ... last ten years, most recently as Senior Vice President ...
... Feb. 21, 2012  Idenix Pharmaceuticals, Inc. (NASDAQ: IDIX ... overview at the Citi Global Healthcare Conference on February 27, ... New York City.   The live and archived ... of Events" in the Idenix Investor Center at ...
Cached Medicine Technology:ConvaTec Announces the Appointment of Ken Berger to the Position of CEO Effective March 6, 2012 2
Classic, stylish, and preppy, this collection features men's, women's and unisex styles....
The latest VALENTINO eyewear collection is a refined expression of sophisticated luxury,balancing ultimate feminine, chic styles against understated, minimalist mens models....
Stylish, elegant and feminine, these attractive frames provide refined and beautiful styles for women ages 40 and older....
The Nine West Eyewear collection is positioned to present today's styles with a sharp, edgy contemporary attitude tied into a clean design element....
Medicine Products: