Navigation Links
Old drug holds promise against opportunistic lung bug
Date:8/19/2010

assistant professor in Pediatrics. "Since we reduced the response of the immune system, you would think the mice would get sicker. But instead, the mice treated with sulfasalazine were healthier. At first we thought it was due solely to the anti-inflammatory activity of the compound, but it turns out that sulfasalazine actually results in a reduced fungal burden. The drug helps the body clear the infection.

"We initially thought we had done something wrong, and so we repeated the experiment again and again. Then, when new technology was developed, we were able to document that the body cleared the infection more readily with sulfasalazine," added Wang.

Scientists have long known that the body's immune T cells are central to the body's response to fight off the infection. The Rochester team showed that the body's T cells spur macrophages to attack the fungus to engulf its particles and chew them up in a process known as phagocytosis.

While scientists have long suspected that role for macrophages, the Rochester team relied on a new technology to gather the first direct evidence of macrophages engulfing fungal particles. The scientists worked closely with Timothy Bushnell, Ph.D., and others at Rochester's Flow Cytometry Resources Core, investigating new ways to use lasers to capture images of molecular events. Bushnell's team ultimately connected the team with scientists at Amnis. Together the group developed a new way to capture macrophage phagocytosis in single cells from mice infected with Pneumocystis. The technology enabled the team to capture more than 40,000 such events, compared to just a handful when using conventional microscopy.

The team showed that as macrophage activity increased, the animals' health improved and levels of fungus decreased. For example, 17 days after infection, mice treated with sulfasalazine had nine times as many macrophages that had engulfed fungal particles compared to mice that had not been
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. AthletiCo Physical Therapy Holds July Cell Phone Drive
2. Chinese Biopharmaceutical Association Successfully Holds 15th Annual Conference
3. U.S. Panel Upholds Ban on Gay Men as Blood Donors
4. SISEL International Holds Successful Launch Events In Ukraine
5. Baden Elementary School holds VisionWalk to Fight Blindness
6. ShenoaDiamonds.com Holds Contest to Give Away $5,000 Diamond Ring, Spurred by Online Sales Growth
7. Construction Accident Lawyer Says Recent News Of Mine Disaster Holds Lessons For Construction Safety
8. ATSU –ASHS Holds Spring Commencement Ceremony
9. Morehead Associates, Inc. Holds Annual Peer to Peer Conference(TM)
10. Gene Holds Key to Embryonic Stem Cell Rejuvenation
11. Ongoing Toyota Recall Holds Serious Liability Implications For Manufacturer, but Consumers Must Be Protected, Says Texas Attorney Brad T. Wyly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... (PRWEB) August 30, 2014 "I had a ... of her crutches," said an inventor from Wetumpka, Ala. "In ... and sounds of the shore, I came up with a ... , She created a prototype for the patent-pending Deezers to ... enables the individual to use crutches, walkers, or canes at ...
(Date:8/30/2014)... 30, 2014 In today’s world, a ... difficult to get. Snoring and sleep apnea (a medical ... stops) robs people and their bed partners of the ... to 45% of the population snores and 20 million ... Of these, only 10% have been diagnosed and treated; ...
(Date:8/30/2014)... 30, 2014 The new review published by ... created by Karen Brimeyer, who wanted to make her guide ... This guide is now easy to find in the form ... this guide, the author of the new method shares all ... Daily Gossip writes in its review that the leaky gut ...
(Date:8/30/2014)... LiveStreamingFitness.com, a company dedicated to providing live ... resources, is proud to announce it has been recognized as ... fitness solutions by ABC’s Good Morning America. ... Good Morning America, “Live Streaming Fitness is the hottest new ... by streamlining your workout…to boot camp at Life Streaming Fitness ...
(Date:8/30/2014)... August 30, 2014 When a prominent bank ... as happened on Wednesday, August 27th, when news began surfacing ... JPMorgan Chase & Co and at least one other ... actually investigating attacks on seven prominent banks , everyone ... be affected, and the buzz quickly goes viral. Bloomberg ...
Breaking Medicine News(10 mins):Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Leaky Gut Cure Review Reveals Unique Method to Stop Chronic Symptoms 2Health News:LiveStreamingFitness.com is New Trend In Fitness 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 3Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 4Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 5
... at Harvard University have created a laboratory model using ... stages of ovarian cancer metastasis. "We were ... for the force-dependent processes associated with metastasis," said Joan ... Harvard University. These findings are published in ...
... awarded Penn State, Penn State Milton S. Hershey Medical ... million, five-year grant designed to accelerate the translation of ... This competitive Clinical and Translational Science Award (CTSA) will ... (CTSI), a collaboration of many Penn State colleges and ...
... , TUESDAY, June 14 (HealthDay News) --,Scheduling classes later in ... in the morning, but it may also encourage them to ... that undergrads whose classes started later were more likely to ... times predicted more drinking, more sleep time and modestly lower ...
... liver fibrosis, such as liver stiffness measurement or the ... C, according to a new study in Gastroenterology ... (AGA) Institute. "Liver stiffness measurement and/or the ... hepatitis C, regardless of the stage of the disease," ...
... 15, the Lymphoma Research Foundation (LRF), in collaboration with ... Center, will bring together lymphoma experts to discuss the ... This event is the final installation of LRF,s 2010-2011 ... series focused on the diagnosis and treatment of lymphoma ...
... Tiny fibres used to strengthen everyday products such as bicycle ... involved in their manufacture. Certain types of carbon nanotubes ... human hair could cause cancer in the lining of ... study in mice found that while short carbon nanotubes appeared ...
Cached Medicine News:Health News:Penn State receives $27.3 million NIH grant 2Health News:Penn State receives $27.3 million NIH grant 3Health News:Penn State receives $27.3 million NIH grant 4Health News:College Students Who Sleep in Drink More, Study Less 2Health News:Noninvasive liver tests may predict hepatitis C patient survival 2Health News:Lymphoma Research Foundation and John Theurer Cancer Center collaborate for Lymphoma Rounds program 2
(Date:8/29/2014)... According to the new ... (Equipment, Reagent, Primer, Probe, Custom Oligos), End-User (Research, ... Synthesis, NGS, DNA, RNAi) - Global Forecast to ... Market is expected to reach $1,712.1 Million by ... a CAGR of 9.8% from 2014 to 2019.. ...
(Date:8/29/2014)... , Aug. 29, 2014  In part ... to leverage a hospital pharmacy as a strategic asset, ... national practice leader for Cardinal Health,s Innovation Delivery Solutions ... care can benefit both hospitals and patients. ... only one part of their job in a value-based ...
(Date:8/29/2014)... Aug. 29, 2014 Research and Markets ... Soft Tissue Repair Devices Market 2014-2018" report to ... the mass of cells that connect, support, or surround ... such as tendons, ligaments, cartilage, fascia, and other fibrous ... these tissues with age result in wear and tear ...
Breaking Medicine Technology:Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 2Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 3Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 4Global Orthopedic Soft Tissue Repair Devices Market 2014-2018: Key Vendors are ArthroCare, Biomet, DePuy Synthes and Smith & Nephew 2Global Orthopedic Soft Tissue Repair Devices Market 2014-2018: Key Vendors are ArthroCare, Biomet, DePuy Synthes and Smith & Nephew 3
... Minn., Oct. 14 AbbeyMoor Medical Inc. ... CPT code by the American Medical Association (AMA) for ... action, effective in January 2010, upgrades The Spanner from ... Category I procedure code for established procedures. This major ...
... 14 CardioGenics Holdings Inc. (OTC Bulletin Board: JAGH), provides ... in the company,s name, ticker symbol and CUSIP number. ... FINRA all documentation requested in connection with the name change, ... number for the company,s common shares. FINRA is working ...
Cached Medicine Technology:AbbeyMoor Medical Receives Category I CPT(R) Code for The Spanner(TM) Prostatic Stent Procedure 2AbbeyMoor Medical Receives Category I CPT(R) Code for The Spanner(TM) Prostatic Stent Procedure 3CardioGenics Holdings Inc. Provides Update on FINRA Submission Regarding Name Change 2
... while minimizing the pain of ... safety-engineered BD Microtainer Genie Lancet. ... offers a full range of ... blood collection and protects the ...
The DiaSTAT™ is an automated liquid chromatography system designed for the rapid and automated analysis of hemoglobin A1C. Ideal for low and ,medium volume testing environments....
The HEMOCHRON Jr. Signature+ Microcoagulation System offers point-of-care monitoring with numerous features to meet the needs of each individual department, as well as the needs of regulatory complia...
Inquire...
Medicine Products: