Navigation Links
Old drug holds promise against opportunistic lung bug
Date:8/19/2010

A drug to treat inflammation plays a surprising role reducing the level of infection caused by an opportunistic bug that is deadly for AIDS and cancer patients and others with weakened immune systems.

The drug, sulfasalazine, spurs the body to get rid of the fungal evaders by enhancing the body's ability to chew them up instead of leaving the debris to litter the lungs, where it would continue to provoke an onslaught of harmful inflammation.

Besides opening a new avenue for research on Pneumocystis pneumonia or PCP, caused by the fungus Pneumocystis jirovecii, the work with mice also offers the possibility of manipulating immune cells called macrophages to improve treatment of infections.

The findings by scientists at the University of Rochester Medical Center were published August 19 in the journal PLoS Pathogens.

During a bout with Pneumocystis, the lungs become a battlefield, where the body pits an array of impressive forces against marauding microbes. But even when the body gets the upper hand, the damage is tremendous. Immune cells like neutrophils and macrophages can flood the lungs, literally suffocating the patient. And when the debris from dead microbes fills the lungs, more and more immune cells are called in to clean up the area, making matters worse. It becomes harder and harder to breathe.

"Many people assume that once the microbe is dead, patients usually start to feel better immediately. But with Pneumocystis, patients do not always undergo a rapid clinical improvement following antibiotic treatment. Even though the bug has been killed, the debris that is left in the lungs continues to promote inflammation," said corresponding author Terry Wright, Ph.D., an infectious disease specialist and associate professor of Microbiology and Immunology and of Pediatrics.

Pneumocystis is a common bug that infects nearly everyone at some point; the authors say that
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

1

GOOD

Page: 1 2 3 4

Related medicine news :

1. AthletiCo Physical Therapy Holds July Cell Phone Drive
2. Chinese Biopharmaceutical Association Successfully Holds 15th Annual Conference
3. U.S. Panel Upholds Ban on Gay Men as Blood Donors
4. SISEL International Holds Successful Launch Events In Ukraine
5. Baden Elementary School holds VisionWalk to Fight Blindness
6. ShenoaDiamonds.com Holds Contest to Give Away $5,000 Diamond Ring, Spurred by Online Sales Growth
7. Construction Accident Lawyer Says Recent News Of Mine Disaster Holds Lessons For Construction Safety
8. ATSU –ASHS Holds Spring Commencement Ceremony
9. Morehead Associates, Inc. Holds Annual Peer to Peer Conference(TM)
10. Gene Holds Key to Embryonic Stem Cell Rejuvenation
11. Ongoing Toyota Recall Holds Serious Liability Implications For Manufacturer, but Consumers Must Be Protected, Says Texas Attorney Brad T. Wyly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... (PRWEB) June 19, 2013 Kansas City will host ... Main Street Day . A section of Main Street in ... during the afternoon of the event. The Main Street Corridor ... event, which will help Kansas City join the ranks of dozens ... as a tool to foster community vibrancy and active lifestyles. , ...
(Date:6/19/2013)... In 2011, the value of the ... Generic drugs form the largest sector, accounting for nearly ... industry is a significant contributor to the local economy; ... Approximately 50% of the total domestic chemical industry output ... Galenika and Zdravlje Actavis are key participants in the ...
(Date:6/19/2013)... 19, 2013 Elsevier, a world-leading provider of ... announced today the publication of the National Osteoporosis ... management of osteoporosis in postmenopausal women and older ... Published in 2009 in Maturitas , the ... update is timely with an additional focus on ...
(Date:6/19/2013)... Next Thursday, June 27, 2013, ... organization, and Muzzy Lane Software , a ... the Games for Health community to their interactive ... toward students in grades 4-7 and designed to ... positive choices. The game is part of a ...
(Date:6/19/2013)... Maui'd Forever , Hawaii's premiere ... an effective and cost effective way to provide for ... up with Tom Barefoot’s Tours providing an activity agent ... Hawaii’s activities. , They have just released a new ... lowest prices on their Hawaii activities. , Maui’d ...
Breaking Medicine News(10 mins):Health News:Main Street Corridor Development Corporation and BikeWalkKC Partner to Host Main Street Day and Kansas City’s First Ciclovia 2Health News:Main Street Corridor Development Corporation and BikeWalkKC Partner to Host Main Street Day and Kansas City’s First Ciclovia 3Health News:Serbian Pharmaceutical Market Scrutinized by CUBE in Topical Report Now Available at MarketPublishers.com 2Health News:Adventure Game for Tweens to Promote Healthy Eating will be Unveiled at Games For Health Conference 2Health News:Adventure Game for Tweens to Promote Healthy Eating will be Unveiled at Games For Health Conference 3Health News:Adventure Game for Tweens to Promote Healthy Eating will be Unveiled at Games For Health Conference 4Health News:Adventure Game for Tweens to Promote Healthy Eating will be Unveiled at Games For Health Conference 5Health News:Maui'd Forever Pleased to Offer Price Guarantee on Hawaii Activities 2
... N.J., Oct. 8 QMed, Inc., (Nasdaq:,QMED) today announced ... plan,customer for an additional three years. Under the terms ... for stroke and coronary,heart disease. In addition, the Company ... and financial performance measures. Jane Murray, QMed president ...
... SAN DIEGO, Oct. 8 The Sidney ... Sparhawk Corporation to raise,funds through a Sparhawk e-Fundraising ... alliance, supporters of SKCC can help raise funds ... http://skcc.org/shop . The eMall has links to hundreds ...
... Oct. 8 A good night,s sleep,is an ... estimated 70,million Americans complain of sleeplessness. This October, ... is offering,advice to help consumers select comfortable mattresses ... neck pain., "Americans spend one-third of their ...
... Oct. 8 Beginning in October, Concentra,("Concentra" or the ... For What Ails,You. This new theme is at the ... centers to various communities in the coming,year, beginning with ... area. The For What Ails You campaign is ...
... IPF Patients Across U.S. to Hear ... from Top Experts, ... people who suffer from Idiopathic Pulmonary Fibrosis (IPF),is the limitation the disease ... Pulmonary Fibrosis (CPF) overcomes that,obstacle for these patients by allowing them to ...
... Enhancements for Long-Term Care Facilities Enable More Proactive Care ... Help Maximize Reimbursement ... Inc.,announces the launch of AccuNurse Version 2.0, for voice-powered, ... care (LTC) industry. The enhanced features of AccuNurse ...
Cached Medicine News:Health News:QMed, Inc. Extends Agreement & Receives $550,000 Performance Bonus 2Health News:Sidney Kimmel Cancer Center to Boost Revenue Through Support From E-Fundraising Mall 2Health News:Proper Mattress Can Improve Sleep Comfort, Reduce Pain, Says American Chiropractic Association 2Health News:Proper Mattress Can Improve Sleep Comfort, Reduce Pain, Says American Chiropractic Association 3Health News:Concentra Offers a Cure 'For What Ails You' 2Health News:CPF 'Living with IPF' Patient Seminar to be Webcast Live October 13, 2007 2Health News:CPF 'Living with IPF' Patient Seminar to be Webcast Live October 13, 2007 3Health News:Vocollect Healthcare Systems Launches AccuNurse(R) Version 2.0 2Health News:Vocollect Healthcare Systems Launches AccuNurse(R) Version 2.0 3
(Date:6/19/2013)... June 19, 2013 Amerivet Solutions, LLC ... all branches of government from Federal to Municipal, ... their facilities to include complex metal design and ... some very complex aluminum parts for the Defense ... our capabilities to service government contracts," states ...
(Date:6/19/2013)... WHITE PLAINS, N.Y. , June 19, 2013 /PRNewswire/ ... is supporting more than 300 research projects with one ... patients. And in 2013, "Team In Training" (TNT), a ... largest endurance sports training program, is marking its landmark ... LLS invest more than $875 million in research to ...
(Date:6/19/2013)... Pharma IQ is pleased to announce the release ... results from an industry survey conducted earlier this year. ... would be an area of active investment in the next ... more clinical trials in the BRIC region. The infographic, created ... Summit explores the latest trends, challenges and opportunities ...
Breaking Medicine Technology:Amerivet Solutions Expands to Manufacture Complex Metal Designs 2Celebrating 25 Years and Counting: Leukemia and Lymphoma Society's "Team In Training" Goes the Distance and Beyond for Blood Cancer Patients 2Celebrating 25 Years and Counting: Leukemia and Lymphoma Society's "Team In Training" Goes the Distance and Beyond for Blood Cancer Patients 3Celebrating 25 Years and Counting: Leukemia and Lymphoma Society's "Team In Training" Goes the Distance and Beyond for Blood Cancer Patients 4Celebrating 25 Years and Counting: Leukemia and Lymphoma Society's "Team In Training" Goes the Distance and Beyond for Blood Cancer Patients 5Pharma IQ Presents the Latest Trends in Clinical Trial Supply 2
... 2011 Mitsubishi Chemical Medience Corporation announced today ... has granted 510(k) premarketing notification clearance to the ... the way for its sale in the United ... with the PATHFAST analysis system, a unique, self-contained, ...
... Sanomedics International Holdings, Inc. (Pink Sheets: SIMH ... Co-founder and President of Sanomedics International Holdings, Inc. ... Co-founder and President of Watermark Medical , to the ... of Charlie to the Sanomedics Board and the ...
Cached Medicine Technology:Mitsubishi Chemical Medience Corporation Receives 510(k) Clearance for PATHFAST® cTnI-II (cardiac Troponin I) Test in U.S. 2Mitsubishi Chemical Medience Corporation Receives 510(k) Clearance for PATHFAST® cTnI-II (cardiac Troponin I) Test in U.S. 3Mr. Charlie Alvarez Joins the Board of Sanomedics International Holdings, Inc. 2Mr. Charlie Alvarez Joins the Board of Sanomedics International Holdings, Inc. 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: