Navigation Links
Old drug holds promise against opportunistic lung bug
Date:8/19/2010

A drug to treat inflammation plays a surprising role reducing the level of infection caused by an opportunistic bug that is deadly for AIDS and cancer patients and others with weakened immune systems.

The drug, sulfasalazine, spurs the body to get rid of the fungal evaders by enhancing the body's ability to chew them up instead of leaving the debris to litter the lungs, where it would continue to provoke an onslaught of harmful inflammation.

Besides opening a new avenue for research on Pneumocystis pneumonia or PCP, caused by the fungus Pneumocystis jirovecii, the work with mice also offers the possibility of manipulating immune cells called macrophages to improve treatment of infections.

The findings by scientists at the University of Rochester Medical Center were published August 19 in the journal PLoS Pathogens.

During a bout with Pneumocystis, the lungs become a battlefield, where the body pits an array of impressive forces against marauding microbes. But even when the body gets the upper hand, the damage is tremendous. Immune cells like neutrophils and macrophages can flood the lungs, literally suffocating the patient. And when the debris from dead microbes fills the lungs, more and more immune cells are called in to clean up the area, making matters worse. It becomes harder and harder to breathe.

"Many people assume that once the microbe is dead, patients usually start to feel better immediately. But with Pneumocystis, patients do not always undergo a rapid clinical improvement following antibiotic treatment. Even though the bug has been killed, the debris that is left in the lungs continues to promote inflammation," said corresponding author Terry Wright, Ph.D., an infectious disease specialist and associate professor of Microbiology and Immunology and of Pediatrics.

Pneumocystis is a common bug that infects nearly everyone at some point; the authors say that
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. AthletiCo Physical Therapy Holds July Cell Phone Drive
2. Chinese Biopharmaceutical Association Successfully Holds 15th Annual Conference
3. U.S. Panel Upholds Ban on Gay Men as Blood Donors
4. SISEL International Holds Successful Launch Events In Ukraine
5. Baden Elementary School holds VisionWalk to Fight Blindness
6. ShenoaDiamonds.com Holds Contest to Give Away $5,000 Diamond Ring, Spurred by Online Sales Growth
7. Construction Accident Lawyer Says Recent News Of Mine Disaster Holds Lessons For Construction Safety
8. ATSU –ASHS Holds Spring Commencement Ceremony
9. Morehead Associates, Inc. Holds Annual Peer to Peer Conference(TM)
10. Gene Holds Key to Embryonic Stem Cell Rejuvenation
11. Ongoing Toyota Recall Holds Serious Liability Implications For Manufacturer, but Consumers Must Be Protected, Says Texas Attorney Brad T. Wyly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2015)... “ BolehVPN ” was featured on NewsWatch as part of ... technology products available to consumers. Scott Steinberg, a technology expert ... with viewers how to protect their private information. , A ... and even more so online. It helps everyone stay connected ... world. In terms of work, the internet makes things more ...
(Date:5/3/2015)... MA (PRWEB) May 03, 2015 SpineFrontier, ... clearance from the FDA to produce and market their ... device can be used in outpatient settings and is ... The alternate posterior approach has been extensively researched and ... 510k approval to use this approach in conjunction with ...
(Date:5/2/2015)... As one of only 30 Illinois companies ... Health Achievement and Recognition Program (SHARP) certification, Essentra ... the Illinois Department of Labor to host this special ... certification by the Occupational Safety and Health Administration’s (“OSHA”) ... to meet or exceed all of the necessary regulations ...
(Date:5/2/2015)... “ ActOn ” was featured on NewsWatch ... at the latest and coolest applications on the market for ... and technology expert, conducted the app review and shared with ... organizations to make a difference. , In this material world, ... that aren’t about money, which is why those things should ...
(Date:5/2/2015)... FL (PRWEB) May 02, 2015 We ... selected The Delray Recovery Center as one of the ... is known in the addiction treatment field for their ... members to innovate and to continue their educational efforts. ... positive workplace environment, never forgetting their purpose – to ...
Breaking Medicine News(10 mins):Health News:A Method to Keep Private Information Secure was Featured on NewsWatch Television 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 3Health News:An Application to Help People Make a Difference Was Featured on NewsWatch Television 2Health News:The Delray Recovery Center Named 2015 Top Workplace 2
... screens, researchers say , TUESDAY, June 2 (HealthDay News) -- ... more types of cancer than previously thought, a new study ... successfully used for early detection of colorectal cancer, researchers at ... also good at finding other gastrointestinal cancers, such as those ...
... that a noninvasive screening test can detect not only colorectal ... including pancreas, stomach, biliary and esophageal cancers. This is one ... Digestive Disease Week 2009 in Chicago, May 30 June ... in four cancer deaths. While high cure rates can be ...
... New York, NY 2 June 2009 -- PharmaPendium ... clinical and post-marketing drug information, has significantly expanded its ... documents with the launch of the FDA Classic Collection. ... up to and including those issued in 1991 ...
... to use a new, cutting edge diagnostic technology to fight ... , WOBURN, Mass., and VEDBAEK, Denmark, June 2 ... Savannah, Georgia has implemented AdvanDx,s PNA FISH(R) tests to identify ... to help their physicians, pharmacists and nurses improve care and ...
... Pa., June 2 Globus Medical, Inc., the largest privately ... launch of the COALITION(TM) ACDF Spacer System. COALITION(TM) is ... biomechanical strength of a traditional ACDF with less disruption of ... , The COALITION(TM) technology combines a PEEK interbody spacer with ...
... Del., June 2 Two studies from ... gastroesophageal reflux disease (GERD) patients treated with NEXIUM(R) (esomeprazole ... heartburn and GERD-related sleep disturbances compared with patients taking ... for the treatment of heartburn and other symptoms associated ...
Cached Medicine News:Health News:Simple Test Could Detect More Gastrointestinal Cancers 2Health News:Improved DNA stool test could detect digestive cancers in multiple organs 2Health News:Improved DNA stool test could detect digestive cancers in multiple organs 3Health News:Elsevier's PharmaPendium introduces the FDA Classic Collection 2Health News:Memorial University Medical Center (MUMC) Implements PNA FISH(R) Tests to Help Provide Best Care for Patients with Bloodstream Infections 2Health News:Memorial University Medical Center (MUMC) Implements PNA FISH(R) Tests to Help Provide Best Care for Patients with Bloodstream Infections 3Health News:Globus Medical Announces Launch of COALITION(TM) ACDF Spacer System 2Health News:AstraZeneca Studies Show Relief of Nighttime Heartburn and Reduction in GERD-Related Sleep Disturbances 2Health News:AstraZeneca Studies Show Relief of Nighttime Heartburn and Reduction in GERD-Related Sleep Disturbances 3Health News:AstraZeneca Studies Show Relief of Nighttime Heartburn and Reduction in GERD-Related Sleep Disturbances 4Health News:AstraZeneca Studies Show Relief of Nighttime Heartburn and Reduction in GERD-Related Sleep Disturbances 5
(Date:5/1/2015)... , May 01, 2015 Research and Markets ... the "US ACO IT Spending Outlook 2018" ... that number of lives covered by ACO would grow ... this report, the ACO IT spending has been studied ... on software and spending on services. Our research provides ...
(Date:5/1/2015)... May 1, 2015  Thoratec Corporation (NASDAQ: THOR ), ... support and restore failing hearts, announced today that Marta ... of President, International. This new Europe ... outside of North America , including ... Latin America , and reports directly to ...
(Date:5/1/2015)... Corporation (CYTR), a biopharmaceutical research and development company ... the three months ended March 31, 2015, and ... milestones for its clinical development programs. ... of 2015, including the announcement of encouraging data ... with soft tissue sarcoma, and positive interim data ...
Breaking Medicine Technology:United States ACO IT Spending Outlook 2014-2018 2Thoratec Announces Addition To Senior Management Team 2Thoratec Announces Addition To Senior Management Team 3CytRx Reports First Quarter 2015 Financial Results 2CytRx Reports First Quarter 2015 Financial Results 3CytRx Reports First Quarter 2015 Financial Results 4CytRx Reports First Quarter 2015 Financial Results 5CytRx Reports First Quarter 2015 Financial Results 6CytRx Reports First Quarter 2015 Financial Results 7CytRx Reports First Quarter 2015 Financial Results 8CytRx Reports First Quarter 2015 Financial Results 9CytRx Reports First Quarter 2015 Financial Results 10CytRx Reports First Quarter 2015 Financial Results 11
... stimulants combined provide greater improvement in symptoms ... Addrenex Pharmaceuticals, Inc. today announced positive results ... Clonicel demonstrating that the combination of Clonicel ... in attention deficit hyperactivity disorder (ADHD) symptoms ...
... After a review of several vendors, the University ... selected the services of Velos and its flagship product, ... implemented at UCLA,s Jonsson Comprehensive Cancer Center and an ... Plans are in place to deploy the system in ...
Cached Medicine Technology:Addrenex Pharmaceuticals Reports Positive Results in Second Phase 3 Study of ADHD Medication 2University of California Los Angeles Selects Velos eResearch 2University of California Los Angeles Selects Velos eResearch 3University of California Los Angeles Selects Velos eResearch 4University of California Los Angeles Selects Velos eResearch 5University of California Los Angeles Selects Velos eResearch 6
The Ultra HDL (UHDL) assay is used for the quantitation of high density lipoprotein (HDL) cholesterol in human serum or plasma....
Shandon Paraffin Block Cartons...
... embedment block cataloging and ... system incorporates the necessary ... protection, simplified cataloging, reduction ... facilitation of retrieval. All ...
The Modular Storage Drawers provide permanent storage and identification of up to 165 embedding rings or 250 cassettes per drawer....
Medicine Products: