Navigation Links
Old antibiotic may find new life as a stroke treatment
Date:5/19/2008

s. Every study patient will get one of four doses, starting with 200 milligrams, the most common dose already used, and increasing incrementally up to 700 milligrams. Theyll get half their first dose at subsequent 12-hour intervals for a three-day period then be followed for 90 days.

We are going to be drawing samples from patients to make sure we achieve the concentrations that we want in the blood, plus we want to define the half-life in stroke patients to see if its different than in the younger patients who take it for other reasons, says Dr. Fagan. Newer intravenous antibiotics have replaced minocycline in the United States, but an oral version is used to treat conditions such as acne and rheumatoid arthritis. If the half-life is longer, we can give it less frequently. We are really fine-tuning the dose, she says. Theyll do this by looking in the blood for biomarkers, indicators of inflammation, to see if inflammatory factors go up after three days. It may give us a clue we should treat patients longer, says Dr. Fagan, a co-investigator on the studies leading to minocyclines use in rheumatoid arthritis.

One way minocycline fights inflammation is by inhibiting microglial cells, white blood cells activated by a stroke, says Dr. Hess. When they get activated, they get angry and produce materials that damage the brain. The inflammatory cascade is bad and good. Early on its bad, later on it may actually do some good things, he says. Typically these microglial cells are sentinel immune cells for the brain, helping eliminate infections and secreting factors that support neurons. However, acutely in a stroke, brain tissue can become their target. They are basically cleaning house at first, then later, they are supportive, releasing growth factors and promoting the growth of new blood vessels, adds Dr. Fagan.

Minocycline also blocks matrix metallo-proteinases, also released during stroke, which destroy the basement membrane of blood vessels.
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-8596
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. ASGE issues updated guidelines on antibiotic prophylaxis for gastrointestinal endoscopy
2. Aida Pharmaceuticals, Inc. Announces New Antibiotic Drug Under Development
3. Gator Blood May Be New Source of Antibiotics
4. Injectable Antibiotic Protects Against Lyme Disease in Mice
5. Green Tea Boosts Antibiotics for Superbugs
6. Dont Prescribe Antibiotics for Adult Sinus Woes
7. Research could put penicillin back in battle against antibiotic resistant bugs that kill millions
8. Synthetic peptoids hold forth promise for new antibiotics
9. FDA Extends Review Timeline for Additional Indication for Antibiotic DORIBAX(TM)
10. Affinium Pharmaceuticals, Ltd. Announces Initiation of a Phase I Clinical Trial for AFN-1252, its Novel Anti-staphylococcal Antibiotic
11. Bacteria beware: MIT student invents knock-out punch for antibiotic resistance
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Old antibiotic may find new life as a stroke treatment
(Date:10/31/2014)... The Memory Healer review published by DailyGossip.org ... whose father suffered from Alzheimer's disease. , In fact, ... his father's disease. His father pointed a gun and shot ... when the author of this method understood that he needed ... Memory Healer program is based on years of research. The ...
(Date:10/31/2014)... Lee's Summit, Missouri (PRWEB) October 31, 2014 ... circulated the country about families narrowly escaping carbon monoxide ... winter season) looms just weeks away, one family-owned, Missouri-based ... and straightforward approach to making sure families start the ... systems are safe and secure. , Beginning Nov. ...
(Date:10/31/2014)... 31, 2014 (HealthDay News) -- Surgery for low back ... in the United States you live, a new report ... low back pain at some point in their lives, ... medical care for a spine problem," co-author Brook Martin, ... Practice, said in a college news release. In ...
(Date:10/31/2014)... is a major contributor to deaths caused by motor ... underscore the importance of the "Sleep Well, Be Well" ... Results show that the risk of unintentional fatal injury ... insomnia symptoms present. People with all three symptoms of ... a fatal injury than those with no insomnia symptoms, ...
(Date:10/31/2014)... The Suspension Revolution review published by ... developed by Dan Long, a suspension training specialist. ... professional and life coach. The author of this program ... is not impossible , The Suspension Revolution review reveals ... training promises efficiency when it comes to burning fat, ...
Breaking Medicine News(10 mins):Health News:"Memory Healer" Review Reveals a New Natural Remedy Guide for Managing Memory Loss 2Health News:Many Homeowners Missing Key Safety Risks with Home Heating;Missouri-based Company E and Q Announces New Safety Check 2Health News:Many Homeowners Missing Key Safety Risks with Home Heating;Missouri-based Company E and Q Announces New Safety Check 3Health News:Spinal Surgery Varies by Region in U.S.: Study 2Health News:Insomnia increases risk of motor vehicle deaths, other fatal injuries 2Health News:Suspension Revolution Review Reveals Dan Long's New Suspension Workout Plan 2
... a non-profit organization focused on supporting innovative early ... at its fall Fellowship Award Committee review. ... outstanding postdoctoral scientists conducting basic and translational cancer ... across the country. The Fellowship encourages the nation,s ...
... Mozes HealthDay Reporter , WEDNESDAY, Jan. 5 (HealthDay ... amounts of vigorous physical exercise appear to lower their risk ... hours a week or more of vigorous biking, tennis, jogging ... the research team found. But they added that even moderate ...
... 5 (HealthDay News) -- The number of American adults treated for ... 9 million to 19 million, says a federal government report released ... diabetes increased from 4.3 million to 8 million among people age ... 45 to 64; and 1.2 million to 2.4 million among people ...
... Gehrig,s disease, or amyotrophic lateral sclerosis (ALS), and frontotemporal ... brain and spinal-cord cells that include an RNA-binding protein ... of the lesions formed by these clumps. ... Clinical Investigation , a team led by Virginia M.-Y. ...
... HealthDay Reporter , WEDNESDAY, Jan. 5 (HealthDay News) ... be treatable with a vaccine that has been engineered ... with a cocaine-like substance that mimics cocaine,s molecular composition. ... effective and long-lasting antibody immune response, attacking cocaine molecules ...
... at Mount Sinai School of Medicine has developed the ... This instrument has recently been used by soldiers returning ... in the Sixth Annual Road to Recovery Conference and ... TBI. "Traumatic brain injury is underdiagnosed, and ...
Cached Medicine News:Health News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 12 top young scientists 2Health News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 12 top young scientists 3Health News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 12 top young scientists 4Health News:Exercise May Improve Odds Against Prostate Cancer Death 2Health News:Exercise May Improve Odds Against Prostate Cancer Death 3Health News:Exercise May Improve Odds Against Prostate Cancer Death 4Health News:Diabetes Soaring Among American Adults: Report 2Health News:Malfunctioning gene associated with Lou Gehrig's disease leads to nerve-cell death in mice 2Health News:Vaccine Protects Mice From Cocaine's Effects, Study Finds 2Health News:Vaccine Protects Mice From Cocaine's Effects, Study Finds 3Health News:Mount Sinai develops first screening tool for war veterans to assess traumatic brain injury 2
(Date:10/31/2014)... , October 31, 2014 Investor-Edge ... (NASDAQ: NSPH ), Isis Pharmaceuticals Inc. (NASDAQ: ... HALO ), ACADIA Pharmaceuticals Inc. (NASDAQ: ... research on these five companies can be accessed at: ... 2014, the NASDAQ Composite ended at 4,566.14, up 0.37%, ...
(Date:10/31/2014)... (OTCQB:ECIA), a medical device company owning patented surgical technology ... surgery, today announced financial results for its fiscal 2015 ... Company posted quarterly net revenue of $2.279 million for ... per share. These results compare to net revenue of ... or $(0.01) per share, in the year-ago quarter. Gross ...
(Date:10/31/2014)... 2014 Research ... of the  "Process Validation in the US and ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,Key topics to ... Approach to Process Validation for Pharmaceutical and Biopharmaceutical ... FDA Process Validation Guidance EU Process ...
Breaking Medicine Technology:Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 2Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 3Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 4Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 5Encision Reports Second Quarter Fiscal Year 2015 Results 2Encision Reports Second Quarter Fiscal Year 2015 Results 3Encision Reports Second Quarter Fiscal Year 2015 Results 4Encision Reports Second Quarter Fiscal Year 2015 Results 5Process Validation in the US and EU (Workshop, London) 2Process Validation in the US and EU (Workshop, London) 3Process Validation in the US and EU (Workshop, London) 4
... The U.S. Food and Drug Administration today issued draft ... previously cleared 510(k) device require a new premarket submission. ... The 510(k) process is the most common review path ... a device, manufacturers must submit a premarket notification or ...
...   UK pharma group ... quarter but highlights strong underlying sales momentum. ... CEO Andrew Witty and CFO Simon Dingemans review Q2 ... strategy, improving margins and a review of the recently ...
Cached Medicine Technology:FDA Issues Draft Guidance on Device Changes That Warrant New Premarket Review 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: