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Oklahoma scientists discover promising new path for treating traumas
Date:10/25/2009

Sciences.

The researchers have already tested the antibodies in pre-clinical trials, where they showed promising results and no adverse effects. A potential future step, said Esmon, would be human trials.

"The implications for this discovery are staggering," said OMRF President Stephen Prescott, M.D. "Dr. Esmon and his colleagues have not only found a new key player in cardiovascular injuries and disease, but they've taken this work and transformed it into a potential treatment for severe trauma, diabetes, pneumonia and any other condition that results in tissue death."

The work, said Prescott, also helps lay a foundation for future research. "These findings offer some clues as to why people suffering from one traumatic injury often experience a catastrophic 'cascade' of secondary traumatic events," he said. "If we can figure out how to control the initial injury, perhaps that will stop the domino effect that so often follows."

Esmon's research has already yielded two FDA-approved drugs. His work with OMRF researcher Fletcher Taylor, M.D., led to the creation of Xigris, a treatment for severe sepsis. And with his wife and colleague, Naomi Esmon, Ph.D., he helped create Ceprotin, a therapeutic for patients suffering from a life-threatening protein deficiency.


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Contact: Greg Elwell
greg-elwell@omrf.org
405-271-8955
Oklahoma Medical Research Foundation
Source:Eurekalert  

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