Navigation Links
Oklahoma scientists discover promising new path for treating traumas
Date:10/25/2009

OKLAHOMA CITY, Oct. 26, 2009 A discovery by scientists at the Oklahoma Medical Research Foundation could help save lives threatened by traumatic injuries like those sustained in car crashes or on the battlefield. The work also holds potential for treating severe infectious diseases and diabetes.

In a paper published online today in the advance edition of the scientific journal Nature Medicine, OMRF researcher Charles Esmon, Ph.D., with co-authors Florea Lupu, Ph.D., and Jun Xu, Ph.D., has cast new light on how proteins called histones can enter the bloodstream and begin to kill the lining of blood vessels, resulting in uncontrolled internal bleeding. Building on this work, Esmon and a team of collaborators have discovered an antibody that could counter this deadly process.

"This discovery could open the door to new ways to treat soldiers hurt in IED attacks, gunshot wound victims and people who suffer a traumatic injury," said Esmon, who holds the Lloyd Noble Chair in Cardiovascular Biology at OMRF. "When we realized that histones were so toxic, we immediately went to work looking for a way to stop their destructive tendencies."

Inside the cells, histones perform an important function, keeping DNA coiled and compressed inside the nucleus. But the OMRF researchers found that when cells become damaged and bursteither through injury, infection or diseases such as diabeteshistones can enter the bloodstream and begin to kill the lining of blood vessels. This results in uncontrolled internal bleeding and fluid build-up in the tissues, which are life-threatening.

Working with Temple University's Marc Monestier, M.D., Ph.D., the group discovered antibodies (pathogen-fighting proteins produced by the body's immune system) that can block the histones' ability to kill. "When a patient is suffering from severe bleeds, these antibodies could prevent multi-organ failure," said Esmon, who is a member of the National Academy of Sciences.

The researchers have already tested the antibodies in pre-clinical trials, where they showed promising results and no adverse effects. A potential future step, said Esmon, would be human trials.

"The implications for this discovery are staggering," said OMRF President Stephen Prescott, M.D. "Dr. Esmon and his colleagues have not only found a new key player in cardiovascular injuries and disease, but they've taken this work and transformed it into a potential treatment for severe trauma, diabetes, pneumonia and any other condition that results in tissue death."

The work, said Prescott, also helps lay a foundation for future research. "These findings offer some clues as to why people suffering from one traumatic injury often experience a catastrophic 'cascade' of secondary traumatic events," he said. "If we can figure out how to control the initial injury, perhaps that will stop the domino effect that so often follows."

Esmon's research has already yielded two FDA-approved drugs. His work with OMRF researcher Fletcher Taylor, M.D., led to the creation of Xigris, a treatment for severe sepsis. And with his wife and colleague, Naomi Esmon, Ph.D., he helped create Ceprotin, a therapeutic for patients suffering from a life-threatening protein deficiency.


'/>"/>

Contact: Greg Elwell
greg-elwell@omrf.org
405-271-8955
Oklahoma Medical Research Foundation
Source:Eurekalert  

Related medicine news :

1. An Innovation in Health Care Opens at a CVS/pharmacy Store in the Oklahoma City Region
2. Health Care Service Corporation Provides Personal Clinical Summaries to Members of its Blue Cross and Blue Shield plans in Illinois, New Mexico, Oklahoma and Texas
3. Blue Cross and Blue Shield of Oklahoma Announces Flexible, Affordable Blue MedicareRx(SM) Medicare Prescription Drug Plans
4. Expanded Options for Medicare Beneficiaries in Oklahoma
5. State Leaders Recognize Oklahomas Improvement in Immunization Rankings
6. LCA-Vision Announces the Opening of its 75th LasikPlus(R) Vision Center in Tulsa, Oklahoma
7. Blue Cross and Blue Shield of Oklahoma Launches an Integrated Medical-Dental Health Program
8. Oklahoma Students Win Be Smart-Dont Start! Contest
9. DNC: Bush-McCain Alert - President Touts Bush-McCain Health Care Agenda in Oklahoma
10. Grubb & Ellis Healthcare REIT Acquires Oklahoma City Medical Portfolio
11. The Most Ordinary Things Can Cause the Most Extraordinary Eye Injuries, Says the Oklahoma Academy of Ophthalmology
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Oklahoma scientists discover promising new path for treating traumas
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... On ... as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle ... honor of the city’s history as home to some of the world’s leading providers ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users ... - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 ... Pro X . Simply select a ProHand generator and drag it above media or ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... N.C. , June 24, 2016  Consumers ... decisions and regulators/payers have placed more emphasis on ... environment, patient support programs in the pharmaceutical industry ... patients, medications. Consequently, pharmaceutical companies are focusing on ... they are providing products and services that improve ...
(Date:6/24/2016)... , June 24, 2016  Global Blood ... biopharmaceutical company developing novel therapeutics for the treatment ... today announced the closing of its previously announced ... stock, at the public offering price of $18.75 ... offering were offered by GBT. GBT estimates net ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
Breaking Medicine Technology: