Navigation Links
Oklahoma scientists discover promising new path for treating traumas
Date:10/25/2009

OKLAHOMA CITY, Oct. 26, 2009 A discovery by scientists at the Oklahoma Medical Research Foundation could help save lives threatened by traumatic injuries like those sustained in car crashes or on the battlefield. The work also holds potential for treating severe infectious diseases and diabetes.

In a paper published online today in the advance edition of the scientific journal Nature Medicine, OMRF researcher Charles Esmon, Ph.D., with co-authors Florea Lupu, Ph.D., and Jun Xu, Ph.D., has cast new light on how proteins called histones can enter the bloodstream and begin to kill the lining of blood vessels, resulting in uncontrolled internal bleeding. Building on this work, Esmon and a team of collaborators have discovered an antibody that could counter this deadly process.

"This discovery could open the door to new ways to treat soldiers hurt in IED attacks, gunshot wound victims and people who suffer a traumatic injury," said Esmon, who holds the Lloyd Noble Chair in Cardiovascular Biology at OMRF. "When we realized that histones were so toxic, we immediately went to work looking for a way to stop their destructive tendencies."

Inside the cells, histones perform an important function, keeping DNA coiled and compressed inside the nucleus. But the OMRF researchers found that when cells become damaged and bursteither through injury, infection or diseases such as diabeteshistones can enter the bloodstream and begin to kill the lining of blood vessels. This results in uncontrolled internal bleeding and fluid build-up in the tissues, which are life-threatening.

Working with Temple University's Marc Monestier, M.D., Ph.D., the group discovered antibodies (pathogen-fighting proteins produced by the body's immune system) that can block the histones' ability to kill. "When a patient is suffering from severe bleeds, these antibodies could prevent multi-organ failure," said Esmon, who is a member of the National Academy of
'/>"/>

Contact: Greg Elwell
greg-elwell@omrf.org
405-271-8955
Oklahoma Medical Research Foundation
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. An Innovation in Health Care Opens at a CVS/pharmacy Store in the Oklahoma City Region
2. Health Care Service Corporation Provides Personal Clinical Summaries to Members of its Blue Cross and Blue Shield plans in Illinois, New Mexico, Oklahoma and Texas
3. Blue Cross and Blue Shield of Oklahoma Announces Flexible, Affordable Blue MedicareRx(SM) Medicare Prescription Drug Plans
4. Expanded Options for Medicare Beneficiaries in Oklahoma
5. State Leaders Recognize Oklahomas Improvement in Immunization Rankings
6. LCA-Vision Announces the Opening of its 75th LasikPlus(R) Vision Center in Tulsa, Oklahoma
7. Blue Cross and Blue Shield of Oklahoma Launches an Integrated Medical-Dental Health Program
8. Oklahoma Students Win Be Smart-Dont Start! Contest
9. DNC: Bush-McCain Alert - President Touts Bush-McCain Health Care Agenda in Oklahoma
10. Grubb & Ellis Healthcare REIT Acquires Oklahoma City Medical Portfolio
11. The Most Ordinary Things Can Cause the Most Extraordinary Eye Injuries, Says the Oklahoma Academy of Ophthalmology
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Oklahoma scientists discover promising new path for treating traumas
(Date:8/5/2015)... ... 05, 2015 , ... HealthyYOU Vending says that recent Health Code legislation against ... County of San Francisco are representative of initiatives across the county encouraging healthier drink ... from the City and County of San Francisco Board of Supervisors (Ordinance 150245) ...
(Date:8/5/2015)... , ... August 05, 2015 , ... ... stevia brand, SweetLeaf®, was honored as one of this year’s 50 Most Influential ... and innovators in Arizona business. Carol May’s long-standing dedication to the well-being of ...
(Date:8/4/2015)... City, NY (PRWEB) , ... August 05, 2015 ... ... honors Deborah Stevens as a 2015-2016 inductee into its VIP ... leadership in business. NAPW is the nation’s leading networking organization exclusively for professional ...
(Date:8/4/2015)... ... ... The Journal of Pain Research has published the review “ The ... says “Both obesity and chronic pain are serious public health concerns in our society. ... other. Rather, there appear to be multiple factors that contribute to each of these ...
(Date:8/4/2015)... ... August 04, 2015 , ... assistPoint Partners, LLC is ... oncology patient assistance programs. Through a secure web portal, assistPoint connects Life Sciences, ... enterprise level, cloud-based application and workflow solution. This provides cancer center patient advocates, ...
Breaking Medicine News(10 mins):Health News:HealthyYOU Vending says San Francisco’s ‘Soda Free Summer’ Initiative and Other Recent Health-related Ordinances Demonstrate Why Healthy Vending is a Growing Industry 2Health News:HealthyYOU Vending says San Francisco’s ‘Soda Free Summer’ Initiative and Other Recent Health-related Ordinances Demonstrate Why Healthy Vending is a Growing Industry 3Health News:Carol May Named One of the Most Influential Woman in Arizona 2Health News:Carol May Named One of the Most Influential Woman in Arizona 3Health News:Carol May Named One of the Most Influential Woman in Arizona 4Health News:NAPW Inducts Deborah Stevens, Executive Assistant to Chairman and CEO at Mirion Technologies, Inc., Into its VIP Woman of the Year Circle 2Health News:The Association between Chronic Pain and Obesity published by Dove Medical Press 2Health News:assistPoint.com Web Site Launched 2
... , , WASHINGTON, Sept. 23 ... Black Caucus Foundation,s Annual Legislative Conference "Capitol Hill Day Summit" this ... as prepared for delivery: , , ... Black Caucus -- the conscience of the Congress. , ...
... , , ... , WASHINGTON, Sept. 23 United Cerebral ... Limits (MyChildWithoutLimits.org), UCP,s pioneering initiative that provides parents of children ... connects parents to a vital social network of parents of ...
... gives America a B-minus for hygiene habits , WEDNESDAY, Sept. ... only a "B-minus" grade in hand-hygiene habits, you,ve still got ... year,s results are up from a "C-minus" last year, but ... Soap and Detergent Association, still finds room for improvement. ...
... , , ... costs , , WASHINGTON, Sept. 23 ... that help people stay healthy, the National Business Coalition on ... guide. Value-Based Benefit Design is an emerging employer trend to ...
... , , , NORTHRIDGE, ... winners of its national Fuel Your Greatness(TM) contest. ... herbs and supplements in the food, drug, mass and club ... across the country and, earlier this year, challenged Americans to ...
... MO, 23 September 2009 Elsevier, a leading ... and services announced today, that the Editors of ... the foremost publication of information about evidence-based dental ... to its recognized experts and valued peer reviewers. ...
Cached Medicine News:Health News:Pelosi Remarks at the Congressional Black Caucus Foundation's Annual Legislative Conference 2Health News:Pelosi Remarks at the Congressional Black Caucus Foundation's Annual Legislative Conference 3Health News:United Cerebral Palsy Presents Online Resource for Parents of Young Children with Developmental Delays 2Health News:NBCH Issues Guide to Help Employers Design Benefit Plans that Keep People Healthy 2Health News:NBCH Issues Guide to Help Employers Design Benefit Plans that Keep People Healthy 3Health News:National 'Greatness' Contest Winners Announced 2Health News:National 'Greatness' Contest Winners Announced 3Health News:Journal of Evidence-Based Dental Practice to offer continuing education units for reviewers 2
(Date:8/4/2015)... -- Eli Lilly and Company (NYSE: LLY ) today ... its intent to end its contract with the university ... Alzheimer,s disease (A4) study. The A4 study is a ... of Alzheimer,s disease in older individuals who have evidence ... but do not show symptoms of memory impairment. A4 ...
(Date:8/4/2015)... SAN FRANCISCO, Calif. , Aug. 4, 2015 /PRNewswire/ ... results for the second quarter and six months ended ... studies with fostamatinib in ITP are progressing and we ... said Raul Rodriguez , president and chief executive ... advancement of our other clinical programs, including evaluating fostamatinib ...
(Date:8/4/2015)... Research and Markets ... the "MRI Systems Market to 2020 - ... Growth Driven by Developing Economies" report to ... 2020 - Focus on Patient Comfort and Operational ... the market, competitive landscape, and trends for three ...
Breaking Medicine Technology:Lilly to End Contract with the University of California, San Diego for A4 Alzheimer's Study 2Lilly to End Contract with the University of California, San Diego for A4 Alzheimer's Study 3Rigel Announces Second Quarter 2015 Financial Results 2Rigel Announces Second Quarter 2015 Financial Results 3Rigel Announces Second Quarter 2015 Financial Results 4Rigel Announces Second Quarter 2015 Financial Results 5Rigel Announces Second Quarter 2015 Financial Results 6Global MRI Systems Market Outlook to 2020 - Focus on Patient Comfort and Operational Efficiency, with Growth Driven by Developing Economies 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: