Navigation Links
Oklahoma scientists discover promising new path for treating traumas
Date:10/25/2009

OKLAHOMA CITY, Oct. 26, 2009 A discovery by scientists at the Oklahoma Medical Research Foundation could help save lives threatened by traumatic injuries like those sustained in car crashes or on the battlefield. The work also holds potential for treating severe infectious diseases and diabetes.

In a paper published online today in the advance edition of the scientific journal Nature Medicine, OMRF researcher Charles Esmon, Ph.D., with co-authors Florea Lupu, Ph.D., and Jun Xu, Ph.D., has cast new light on how proteins called histones can enter the bloodstream and begin to kill the lining of blood vessels, resulting in uncontrolled internal bleeding. Building on this work, Esmon and a team of collaborators have discovered an antibody that could counter this deadly process.

"This discovery could open the door to new ways to treat soldiers hurt in IED attacks, gunshot wound victims and people who suffer a traumatic injury," said Esmon, who holds the Lloyd Noble Chair in Cardiovascular Biology at OMRF. "When we realized that histones were so toxic, we immediately went to work looking for a way to stop their destructive tendencies."

Inside the cells, histones perform an important function, keeping DNA coiled and compressed inside the nucleus. But the OMRF researchers found that when cells become damaged and bursteither through injury, infection or diseases such as diabeteshistones can enter the bloodstream and begin to kill the lining of blood vessels. This results in uncontrolled internal bleeding and fluid build-up in the tissues, which are life-threatening.

Working with Temple University's Marc Monestier, M.D., Ph.D., the group discovered antibodies (pathogen-fighting proteins produced by the body's immune system) that can block the histones' ability to kill. "When a patient is suffering from severe bleeds, these antibodies could prevent multi-organ failure," said Esmon, who is a member of the National Academy of
'/>"/>

Contact: Greg Elwell
greg-elwell@omrf.org
405-271-8955
Oklahoma Medical Research Foundation
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. An Innovation in Health Care Opens at a CVS/pharmacy Store in the Oklahoma City Region
2. Health Care Service Corporation Provides Personal Clinical Summaries to Members of its Blue Cross and Blue Shield plans in Illinois, New Mexico, Oklahoma and Texas
3. Blue Cross and Blue Shield of Oklahoma Announces Flexible, Affordable Blue MedicareRx(SM) Medicare Prescription Drug Plans
4. Expanded Options for Medicare Beneficiaries in Oklahoma
5. State Leaders Recognize Oklahomas Improvement in Immunization Rankings
6. LCA-Vision Announces the Opening of its 75th LasikPlus(R) Vision Center in Tulsa, Oklahoma
7. Blue Cross and Blue Shield of Oklahoma Launches an Integrated Medical-Dental Health Program
8. Oklahoma Students Win Be Smart-Dont Start! Contest
9. DNC: Bush-McCain Alert - President Touts Bush-McCain Health Care Agenda in Oklahoma
10. Grubb & Ellis Healthcare REIT Acquires Oklahoma City Medical Portfolio
11. The Most Ordinary Things Can Cause the Most Extraordinary Eye Injuries, Says the Oklahoma Academy of Ophthalmology
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Oklahoma scientists discover promising new path for treating traumas
(Date:7/23/2014)... 23, 2014 QueenBeeTickets.com is reducing the prices ... coup for rock music fans who are still in the ... visit the site, they can use promo code “DISCOUNT” to ... to view the inventory of discounted tickets at QueenBeeTickets.com. ... August, September and October, with The Eagles concert tickets literally ...
(Date:7/23/2014)... July 23, 2014 Temecula Valley ... Temecula Valley Southern California Wine Country artisan food ... and two nights genuinely nourishing. Savor like locals ... Palumbo, and Vindemia wineries; EAT Marketplace, Palumbo’s Ristorante, ... Temecula Olive Oil,” announced Kimberly Adams, president and ...
(Date:7/23/2014)... 2014 In an effort to help ... Alzheimer’s Disease” at the state level, the National ... Foundation of America (AFA) this week released a ... crisis, and the need for wide-scale implementation of state ... , The white paper outlines recommendations for ...
(Date:7/23/2014)... four in five older Americans living with multiple chronic ... Hopkins Bloomberg School of Public Health finds that the ... your life expectancy. The analysis, one of the first ... life expectancy among the elderly, may help explain why ... , A report on the findings, based on an ...
(Date:7/22/2014)... Recently, iFitDress.com, a popular supplier of wedding dresses and ... of white party dresses to its product category. ... now available on its website. As a special offer, all ... can get a discounted rate, up to 54% off. , ... customers, so its marketing specialist believes the new white party ...
Breaking Medicine News(10 mins):Health News:History of The Eagles Tour Tickets: QueenBeeTickets.com Reduces Prices on Remaining Inventory of Concert Tickets for 2014 Shows 2Health News:12 Artisan Food and Wine Experiences in Temecula Valley Southern California Wine County 2Health News:12 Artisan Food and Wine Experiences in Temecula Valley Southern California Wine County 3Health News:12 Artisan Food and Wine Experiences in Temecula Valley Southern California Wine County 4Health News:National Alliance for Caregiving and Alzheimer’s Foundation of America Release Joint Report to Help States Implement Alzheimer’s Plans 2Health News:National Alliance for Caregiving and Alzheimer’s Foundation of America Release Joint Report to Help States Implement Alzheimer’s Plans 3Health News:Life expectancy gains threatened as more older Americans suffer from multiple conditions 2Health News:Life expectancy gains threatened as more older Americans suffer from multiple conditions 3Health News:Elegant White Party Dresses Now Provided by Distinguished Company iFitDress.com 2
... LITTLE ROCK, Ark., Oct. 13 Keeping fit at a young ... and healthy life, according to new research co-authored by researcher Oscar ... University of Warwick in the United Kingdom. , The article ... 30 and was based on data gathered since 1976 from more ...
... , LONG BEACH, Calif. and FOUNTAIN VALLEY, Calif., Oct. ... lead a forum on how health care reform impacts ... 7 a.m. to 11:30 a.m. at Long Beach Memorial ... the event features leaders from health care, insurance, medical ...
... The year,s most refreshing new grocery item is flying ... ice cream, and more nutritious than juice bars, new Jolly ... with whole fruit that,s picked at the peak of freshness ... because they,re all-natural, low in calories, and packed with vitamins ...
... In response to rising suicide and divorce rates within the ... and families, will present its Weekend to Remember ... couples in the Denver Area from Oct. 23 - 25 ... Weekend to Remember is a marriage getaway ...
... doctors rely on biopsy analysis to determine the progression of ... bioluminescence imaging (BLI), will allow doctors to detect tumors earlier ... involve eye surgery. BLI is a new technology ... an organism to map diseases in a non-invasive way. ...
... S.C.--A new neurosurgical procedure may prove helpful for ... stimulation (EpCS) was found generally safe and provided ... group of patients, according to lead researcher Ziad ... Carolina. The data are reported in the on-line ...
Cached Medicine News:Health News:For Older Adults, Good Nutrition and Exercise Are Key To Staying Healthy & Active 2Health News:For Older Adults, Good Nutrition and Exercise Are Key To Staying Healthy & Active 3Health News:Corporate Leaders Share Perspectives, Solutions of Health Reform's Impact on a Company's Bottom Line at Oct. 20 Forum at Long Beach Memorial Medical Center, Sponsored by the Presidents' Partnership of MemorialCare Health System 2Health News:New Squeezable Whole Fruit Sorbets in Single-Serve Tubes an Instant Hit 2Health News:FamilyLife Supports Military Marriages in Denver Area 2Health News:Bioluminescence imaging used for eye cancer detection 2Health News:New brain stimulation treatment may offer hope for those with treatment resistant depression 2
(Date:7/22/2014)... The Intellectual Property and ... world,s leading provider of intelligent information for ... Clinical Trials Intelligence , its global clinical-drug-trial ... the documentation of more than 180,000 clinical ... and quicker access to critical data and ...
(Date:7/22/2014)... , July 22, 2014  ConvaTec, a privately-held medical ... Clerkin has been appointed chief financial officer of ... Clerkin was previously executive vice president and chief financial ... -based biotechnology company.  Mr. Clerkin was part of a ... Elan, culminating in its sale to Perrigo, a pharmaceutical ...
(Date:7/22/2014)... -- BioDelivery Sciences International, Inc. (BDSI) (NASDAQ: ... appointed Charles J. (Chuck) Bramlage and Dr. ... Board.  Mr. Bramlage is a veteran ... and other commercial functions.  He is currently the Chief ... company that was recently acquired by AstraZeneca and is ...
Breaking Medicine Technology:Thomson Reuters Cortellis Clinical Trials Intelligence Reaches Industry Milestone with 180,000 Clinical Trials 2Thomson Reuters Cortellis Clinical Trials Intelligence Reaches Industry Milestone with 180,000 Clinical Trials 3ConvaTec Names Nigel Clerkin Chief Financial Officer 2BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 2BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 3BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 4BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 5BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 6BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 7
... (NASDAQ: GPRO ) announced today that the Company ... Growth Stock Conference in Chicago on June 15, 2011 at ... presentation is scheduled to be webcast live and may be ... website at www.gen-probe.com . The webcast will be available ...
... Educating the critical players in the pharmaceutical marketplace ... been considered a key component of a successful product ... diminished, education efforts have taken on new importance among ... Facing a competitive environment, organizations with new products are ...
Cached Medicine Technology:Gen-Probe to Webcast Presentation at the William Blair & Company 31st Annual Growth Stock Conference 2Educating Key Stakeholders to Support a Successful Pharmaceutical Product Launch 2
... ophthalmoscope with superior aspherical optics. The separation ... of the aspherical optical system avoids corneal ... allows you to view the whole of ... with a small pupil. Conventional ophthalmoscopes often ...
... optics. Includes XHL halogen bulb. The separation ... of the aspherical optical system avoids corneal ... allows you to view the whole of ... with a small pupil. Conventional ophthalmoscopes often ...
Our standard ophthalmoscopes feature halogen light for true tissue color and consistent, long-lasting illumination, and six apertures for general and specialist use....
... incorporates an innovative and patented new ... This enabling technology makes it easier ... a dramatically wider, more panoramic view ... than ever before achieved with a ...
Medicine Products: