Navigation Links
Oklahoma scientists discover promising new path for treating traumas

OKLAHOMA CITY, Oct. 26, 2009 A discovery by scientists at the Oklahoma Medical Research Foundation could help save lives threatened by traumatic injuries like those sustained in car crashes or on the battlefield. The work also holds potential for treating severe infectious diseases and diabetes.

In a paper published online today in the advance edition of the scientific journal Nature Medicine, OMRF researcher Charles Esmon, Ph.D., with co-authors Florea Lupu, Ph.D., and Jun Xu, Ph.D., has cast new light on how proteins called histones can enter the bloodstream and begin to kill the lining of blood vessels, resulting in uncontrolled internal bleeding. Building on this work, Esmon and a team of collaborators have discovered an antibody that could counter this deadly process.

"This discovery could open the door to new ways to treat soldiers hurt in IED attacks, gunshot wound victims and people who suffer a traumatic injury," said Esmon, who holds the Lloyd Noble Chair in Cardiovascular Biology at OMRF. "When we realized that histones were so toxic, we immediately went to work looking for a way to stop their destructive tendencies."

Inside the cells, histones perform an important function, keeping DNA coiled and compressed inside the nucleus. But the OMRF researchers found that when cells become damaged and bursteither through injury, infection or diseases such as diabeteshistones can enter the bloodstream and begin to kill the lining of blood vessels. This results in uncontrolled internal bleeding and fluid build-up in the tissues, which are life-threatening.

Working with Temple University's Marc Monestier, M.D., Ph.D., the group discovered antibodies (pathogen-fighting proteins produced by the body's immune system) that can block the histones' ability to kill. "When a patient is suffering from severe bleeds, these antibodies could prevent multi-organ failure," said Esmon, who is a member of the National Academy of Sciences.

The researchers have already tested the antibodies in pre-clinical trials, where they showed promising results and no adverse effects. A potential future step, said Esmon, would be human trials.

"The implications for this discovery are staggering," said OMRF President Stephen Prescott, M.D. "Dr. Esmon and his colleagues have not only found a new key player in cardiovascular injuries and disease, but they've taken this work and transformed it into a potential treatment for severe trauma, diabetes, pneumonia and any other condition that results in tissue death."

The work, said Prescott, also helps lay a foundation for future research. "These findings offer some clues as to why people suffering from one traumatic injury often experience a catastrophic 'cascade' of secondary traumatic events," he said. "If we can figure out how to control the initial injury, perhaps that will stop the domino effect that so often follows."

Esmon's research has already yielded two FDA-approved drugs. His work with OMRF researcher Fletcher Taylor, M.D., led to the creation of Xigris, a treatment for severe sepsis. And with his wife and colleague, Naomi Esmon, Ph.D., he helped create Ceprotin, a therapeutic for patients suffering from a life-threatening protein deficiency.


Contact: Greg Elwell
Oklahoma Medical Research Foundation

Related medicine news :

1. An Innovation in Health Care Opens at a CVS/pharmacy Store in the Oklahoma City Region
2. Health Care Service Corporation Provides Personal Clinical Summaries to Members of its Blue Cross and Blue Shield plans in Illinois, New Mexico, Oklahoma and Texas
3. Blue Cross and Blue Shield of Oklahoma Announces Flexible, Affordable Blue MedicareRx(SM) Medicare Prescription Drug Plans
4. Expanded Options for Medicare Beneficiaries in Oklahoma
5. State Leaders Recognize Oklahomas Improvement in Immunization Rankings
6. LCA-Vision Announces the Opening of its 75th LasikPlus(R) Vision Center in Tulsa, Oklahoma
7. Blue Cross and Blue Shield of Oklahoma Launches an Integrated Medical-Dental Health Program
8. Oklahoma Students Win Be Smart-Dont Start! Contest
9. DNC: Bush-McCain Alert - President Touts Bush-McCain Health Care Agenda in Oklahoma
10. Grubb & Ellis Healthcare REIT Acquires Oklahoma City Medical Portfolio
11. The Most Ordinary Things Can Cause the Most Extraordinary Eye Injuries, Says the Oklahoma Academy of Ophthalmology
Post Your Comments:
Related Image:
Oklahoma scientists discover promising new path for treating traumas
(Date:11/29/2015)... ... November 29, 2015 , ... Khanna Vision Institute based in Los Angeles, announced ... November 25th 2015. Peer Certification by the Board is done so the public knows ... is first obtained after the completion of three years of training or Residency in ...
(Date:11/29/2015)... ... November 29, 2015 , ... ProStatic Analog Distortion from Pixel ... specially for Final Cut Pro X. FCPX users can now apply ... controls. Destoying and creating chaotic distortion is now quick and simple, putting film ...
(Date:11/28/2015)... (PRWEB) , ... November 28, 2015 , ... ... exchange technology and teleradiology services, has added Chris Hafey and Claude Hooton to ... at the Radiological Society of North America (RSNA) 2015 Annual Meeting and continues ...
(Date:11/28/2015)... ... November 28, 2015 , ... Beginning November 30th at 6:00 a.m. EST until 11:59 p.m. ... , With possible savings of up to 20% off orders $80 or more to free ... website every few hours. , As a competitive e-commerce website for skin care and cosmetic ...
(Date:11/27/2015)... Angeles, CA (PRWEB) , ... November 27, 2015 , ... ... conversation at the recent 2015 American Dental Association meeting in Washington D.C. revolved around ... help protect a patient’s overall health. The talk stressed the link between periodontal disease ...
Breaking Medicine News(10 mins):
(Date:11/29/2015)... Nov. 29, 2015 CIVCO Medical Solutions ... at the Radiological Society of North ... Chicago November 29 – December 4, ... to offer customers unrivaled versatility, enhanced user experience ... --> ...
(Date:11/27/2015)... 27, 2015 Une nouvelle ... au Bremachlorin contre le cancer avancé.    ... combiner l,immunothérapie au traitement photodynamique au Bremachlorin contre ... Une nouvelle approche consistant à combiner l,immunothérapie ... avancé.    Clinical Cancer Research ...
(Date:11/27/2015)... , Niederlande, November 27, 2015 ... fotodynamischer Bremachlorin-Therapie bei fortgeschrittenem Krebs.   --> ... Bremachlorin-Therapie bei fortgeschrittenem Krebs.   --> ... Bremachlorin-Therapie bei fortgeschrittenem Krebs.   Clinical ... --> Clinical Cancer Research vom ...
Breaking Medicine Technology: