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Oklahoma State University researchers make breakthrough against poxviruses
Date:1/23/2009

ed medication to treat autoimmune diseases," he said.

For example, rheumatoid arthritis is one of the most prevalent autoimmune diseases in which IL-18 is too active, leading to the body attacking its own cells. Deng said seeing how IL-18 interacts with the poxviruses will help with the development of effective inhibitors against overreaction.

"There are still a lot of questions to be answered. This is just the beginning," Deng said. "This opened up a new area to explore: How we design medication for autoimmune diseases. We want to provide more and more structural insights."

Deng and Krumm will continue to do research in the lab created two years ago in November 2006, when Deng joined OSU with funding provided by a start-up fund from DASNR.

"Junpeng is a relatively new assistant professor at OSU and has already demonstrated some excellent work," said Gary Thompson, head of the department of biochemistry and molecular biology. "I'm really impressed with not only Junpeng, but also the quality of work from his Ph.D. students."

Deng and Krumm did their research in the lab at OSU, but recognize the help they had from other researchers.

"Credit also goes to Yan Xiang and Xiangzhi Meng, our collaborators at the University of Texas Health Science Center at San Antonio," Deng said of the multi-institutional effort. "I believe our excellent collaboration will bring more success in the future."


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Contact: Sean Hubbard
sean.hubbard@okstate.edu
405-744-4490
Oklahoma State University
Source:Eurekalert

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