Navigation Links
Oily fish can protect against RA, but smoking and psychosocial stress increase its risk
Date:6/13/2008

Paris, France, Friday 13 June 2008: New data presented today at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France, show that intake of oily fish is associated with a reduced risk of developing rheumatoid arthritis (RA), whereas psychosocial work stress and smoking can increase the risk of developing the condition. The findings, all taken from a large population-based case-control study in Sweden called EIRA (Epidemiological Investigation of Rheumatoid Arthritis), shed light on the important role of environmental and social factors in the development of RA.

Intake of Oily Fish

For the first time, the intake of oily fish has been demonstrated to have a protective effect against the development of RA, reducing an individual's risk by 20-30%. Studying 1,899 subjects with a confirmed diagnosis of RA (fulfilling ACR criteria) and 2,145 controls (randomly selected and matched for age, sex and residential area), investigators concluded that the odds ratio (OR) for developing RA was 0.8 (0.7-1.0) for those who consumed oily fish 1-7 times per week or 1-3 times per month, compared with those who never, or seldom consumed oily fish. Interestingly, no significant association with RA risk was observed for consumption of fish oil supplements.

Smoking Dosage

Tobacco smoking is an established risk factor for RA, but the investigators found that there is a dose dependency for the level of smoking (i.e. the number of cigarettes smoked across a given period) on the odds ratio of developing anti-citrulline (anti-CCP) positive RA. The highest odds ratios were seen in those carrying a risk variant of the susceptibility gene PTPN22. In the study, 1,240 cases and 798 controls were identified as smokers from a total group of 1,419 cases and 1,674 controls via an extensive questionnaire regarding lifestyle factors, including smoking habits.

These subjects were then classified into three different groups according to the number of pack years smoked - less then 10, 10-20 or more than 20 pack years (where one pack-year is equivalent to having smoked one pack per day for one year) and genotyped to determine the presence of the PTPN22 risk allele.

Psychosocial Stress at Work

Psychosocial stress at work, defined as low decision latitude (or low level of control) was found to be associated with a higher risk for RA. Collected via a validated questionnaire, this was demonstrated in both self-reported data (OR=1.6 (95% CI 1.2-2.2)) and JEM (job exposure matrix)-derived data (OR=1.3 (95% CI 1.0-1.7)). These results were only marginally changed when the investigators adjusted the odds ratios for social class and smoking for the 1,221 cases and 1,454 controls who participated in the study.

Mrs Annmarie Wesley of the Institute of Environmental Medicine, Stockholm, Sweden, EIRA investigator and lead author of the oily fish intake study, commented: "The findings from these studies add to an increasing body of evidence to support the assertion that lifestyle modifications can have a significant impact on an individual's risk for developing RA, one of the most common autoimmune diseases, affecting approximately 1% of adults worldwide. We hope that the data will contribute to the growing understanding of the aetiology of RA and, ultimately, its treatment and prevention"


'/>"/>

Contact: Rory Berrie / Camilla Dormer
eularpressoffice@uk.cohnwolfe.com
44-077-892-70392
European League Against Rheumatism
Source:Eurekalert

Related medicine news :

1. National Patient Advocate Foundation Applauds Senators Lautenberg and Brown for Protecting Health Care Coverage for At-Risk Children
2. Study pinpoints strategies that protect older adults physical health
3. Most States Fail to Protect Consumers Against Insurance Company Abuses
4. Sex offenders register provides limited protection for children
5. Insured but poorly protected: 25 million adults are underinsured
6. Rutgers researchers show how the brain can protect against cancer
7. Good Oral Hygiene May Protect Against Heart Infections
8. UNICEF & Merck Partner to Protect 100,000 Children and Young People Against Mumps Epidemic
9. New Jersey Coalition Calls for Investigation of Private Wells to Protect Families from PFOA in Drinking Water
10. Shining a Light on Sunscreen: Sun Protection Misconceptions Unveiled by Dr. Jeffrey Dover and CVS/pharmacy
11. Protect Your Eyes in Style: Cinzia Designs Offers Top Tips for Protecting Your Eyes This Summer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... 2016 , ... In the fourth quarter of 2015, document ... La Valencia Hotel in San Diego, California to discuss changes in the industry ... outstanding franchise, walking away with the coveted David Wright Award of Excellence. ...
(Date:2/5/2016)... ... 2016 , ... Pivot Point Consulting, a leading national Healthcare ... Services for HIT Implementation Support & Staffing report with an outstanding score of ... healthcare executives, managers and clinicians representing over 4,500 hospitals and 2,500 clinics. , ...
(Date:2/5/2016)... ... 05, 2016 , ... Colorize is a web theme package created ... next using Colorize's dynamic moving camera. Colorize is perfect for personal and web related ... environment with 1 to 5 focus points per scene, stage floor scene presets that ...
(Date:2/5/2016)... , ... February 05, 2016 , ... Calls Blacklist has ... completely new user interface design and the developer has fixed known bugs within the ... want to on their phone while not consuming any of their device’s battery power ...
(Date:2/4/2016)... Palos Verdes, CA (PRWEB) , ... February 04, ... ... present at the "It's All About YOU Re-Treat" on February 19-21, 2016, ... You Re-Treat" is at Rancho Palos Verdes, California. These 30 professional speakers, including ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... 2016 Wegener Polyangiitis - Pipeline Review, ... ,Wegener Polyangiitis - Pipeline Review, H2 2015, provides ... This report provides comprehensive information on the ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ...
(Date:2/4/2016)... 4, 2016 Frontier Pharma: Chronic Obstructive ... Innovation Chronic Obstructive Pulmonary Disease ... inflammation of the airways and lungs. Persistent breathing ... the disease one of the leading causes of ... the world. COPD is linked to cumulative exposure ...
(Date:2/4/2016)... Feb. 4, 2016 In response to the opioid ... Deputy Commissioner for Medical Products and Tobacco, along with other ... the agency,s approach to opioid medications. The plan will focus ... patients in pain access to effective relief. ... , Re-examine the risk-benefit paradigm for opioids and ensure ...
Breaking Medicine Technology: