Navigation Links
Ohio State researchers restore immune function in spinal injured mice
Date:8/6/2013

COLUMBUS, Ohio In a new study, researchers at The Center for Brain and Spinal Cord Repair at The Ohio State University Wexner Medical Center show that is possible to restore immune function in spinal injured mice.

People with spinal cord injury often are immune compromised, which makes them more susceptible to infections. Why these people become immune-suppressed is not known, but the Ohio State study found that a disorder called autonomic dysreflexia can cause immune suppression.

Autonomic dysreflexia is a potentially dangerous complication of high-level spinal cord injury characterized by exaggerated activation of spinal autonomic (sympathetic) reflexes. This can cause an abrupt onset of excessively high blood pressure that can cause pulmonary embolism, stroke and in severe cases, death.

"Our research offers an explanation for why people with spinal cord injuries develop a condition referred to as 'central immune depression syndrome.' Their immune systems, which are required to fight off infection, are suppressed due to damage or malfunction in regions of the spinal cord that help control immune function," said principal investigator Phillip G. Popovich, Ph.D., Professor of Neuroscience in Ohio State's College of Medicine and Director of Ohio State's Center for Brain and Spinal Cord Repair.

The study is published in the Journal of Neuroscience.

Researchers found that autonomic dysreflexia develops spontaneously in spinal cord injured mice, and becomes more frequent as time passes from the initial spinal cord injury.

They also found that simple, everyday occurrences that activate normal spinal autonomic reflexes, such as having bowel movements or emptying the bladder, become hyperactive and suppress immune function in people with spinal cord injury.

In the study, Popovich and colleagues were able to restore immune function in mice with spinal cord injuries using drugs that inhibit norepinephrine and glucocorticoids, immune modulatory hormones that are produced during the onset and progression of AD. They also observed in a patient with a high-level spinal cord injury that briefly inducing autonomic dysreflexia impaired immune function, confirming that their findings in mice have relevance to humans.

"Although we don't know how to fix this yet, we also show that it is possible to restore immune function in spinal injured mice," Popovich said. "After spinal cord injury, the ability of the spinal cord to control the immune system is impaired. As result, these individuals become susceptible to infection, and often die from these infections. For those that survive, the infections can impair what little function they have left after the spinal cord injury."

The study found that autonomic dysreflexia causes immune suppression in part by releasing into blood and immune organs high levels of immune modulatory hormones that non-selectively kill mature and immature white blood cells in the spleen, said first author Yi Zhang, a post-doctoral neuroscience researcher at Ohio State.

"Our research is laying the groundwork for potential therapeutic targets for reversing central immune depression syndrome," Zhang said, adding that further research is needed.


'/>"/>

Contact: Eileen Scahill
Eileen.Scahill@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center
Source:Eurekalert

Related medicine news :

1. Study reveals how cancer drug causes diabetic-like state
2. New drug prevents spread of human prostate cancer cells
3. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
4. Intensity Modulated Radiation Therapy optimal for localized prostate cancer
5. Study examines adverse effects among different radiation therapies for prostate cancer
6. Study Casts Doubt on Value of Pricey Prostate Cancer Therapy
7. Warren Buffett Has Early Stage Prostate Cancer
8. Majority of states fail to address youth exposure to alcohol marketing
9. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
10. PSA screening to detect prostate cancer can be beneficial to younger and at-risk men
11. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... ... January 17, 2017 , ... Recently, patients and staff from A Forever ... volunteers and organizations in support of the annual Binder Park Zoo Halloween celebration known ... in colorful costumes of all designs coming out to enjoy games, face painting, and ...
(Date:1/16/2017)... New York, NY (PRWEB) , ... January 16, 2017 , ... ... the grand opening of a new showroom in East Hanover, New Jersey. , “We ... at Gym Source. “The new innovative in-store concept is designed to give clients a ...
(Date:1/16/2017)... , ... January 16, 2017 , ... With the Grand ... on January 8 for use by sports teams and the general public. Built in ... courts that can also be converted into basketball or pickleball courts. The space is ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... ... office , Antoine Dental Center, is currently offering complimentary consultations and financing for ... their teeth examined for bite irregularities and learn about their orthodontic options. Walk-in, ...
(Date:1/16/2017)... IL (PRWEB) , ... January 16, 2017 , ... ... seating manufacturer Prairie Seating. Prairie’s award-winning Reflection® brand of custom seating systems has ... The acquisition provides Permobil with a platform for innovation and growth in the ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... Md. , Jan. 16, 2017  According ... (CT) systems market is valued at $4.9 billion ... for CT, coupled with an aging population with ... of chronic disease, is propelling the market for ... Computed Tomography Markets , focuses on the ...
(Date:1/16/2017)... PUNE, India , January 16, 2017 /PRNewswire/ ... by Allied Market Research, titled, "Sterilization Technologies Market by ... Forecast, 2014-2022," the global sterilization technologies market is expected ... in 2015, growing at a CAGR of 5.8% from ... dominated the market in 2015, with more than half ...
(Date:1/16/2017)... , Jan. 16, 2017   Linde Gas North ... of the assets and business of The Service Center LLC, ... repair services to healthcare providers in the Midwest and Southeast ... Broadview, Illinois , The Service Center also has ... Greenville, South Carolina . Its primary services include: ...
Breaking Medicine Technology: