Navigation Links
Ohio State researchers restore immune function in spinal injured mice
Date:8/6/2013

COLUMBUS, Ohio In a new study, researchers at The Center for Brain and Spinal Cord Repair at The Ohio State University Wexner Medical Center show that is possible to restore immune function in spinal injured mice.

People with spinal cord injury often are immune compromised, which makes them more susceptible to infections. Why these people become immune-suppressed is not known, but the Ohio State study found that a disorder called autonomic dysreflexia can cause immune suppression.

Autonomic dysreflexia is a potentially dangerous complication of high-level spinal cord injury characterized by exaggerated activation of spinal autonomic (sympathetic) reflexes. This can cause an abrupt onset of excessively high blood pressure that can cause pulmonary embolism, stroke and in severe cases, death.

"Our research offers an explanation for why people with spinal cord injuries develop a condition referred to as 'central immune depression syndrome.' Their immune systems, which are required to fight off infection, are suppressed due to damage or malfunction in regions of the spinal cord that help control immune function," said principal investigator Phillip G. Popovich, Ph.D., Professor of Neuroscience in Ohio State's College of Medicine and Director of Ohio State's Center for Brain and Spinal Cord Repair.

The study is published in the Journal of Neuroscience.

Researchers found that autonomic dysreflexia develops spontaneously in spinal cord injured mice, and becomes more frequent as time passes from the initial spinal cord injury.

They also found that simple, everyday occurrences that activate normal spinal autonomic reflexes, such as having bowel movements or emptying the bladder, become hyperactive and suppress immune function in people with spinal cord injury.

In the study, Popovich and colleagues were able to restore immune function in mice with spinal cord injuries using drugs that inhibit norepinephrine and glucocorticoids, immune modulatory hormones that are produced during the onset and progression of AD. They also observed in a patient with a high-level spinal cord injury that briefly inducing autonomic dysreflexia impaired immune function, confirming that their findings in mice have relevance to humans.

"Although we don't know how to fix this yet, we also show that it is possible to restore immune function in spinal injured mice," Popovich said. "After spinal cord injury, the ability of the spinal cord to control the immune system is impaired. As result, these individuals become susceptible to infection, and often die from these infections. For those that survive, the infections can impair what little function they have left after the spinal cord injury."

The study found that autonomic dysreflexia causes immune suppression in part by releasing into blood and immune organs high levels of immune modulatory hormones that non-selectively kill mature and immature white blood cells in the spleen, said first author Yi Zhang, a post-doctoral neuroscience researcher at Ohio State.

"Our research is laying the groundwork for potential therapeutic targets for reversing central immune depression syndrome," Zhang said, adding that further research is needed.


'/>"/>

Contact: Eileen Scahill
Eileen.Scahill@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center
Source:Eurekalert

Related medicine news :

1. Study reveals how cancer drug causes diabetic-like state
2. New drug prevents spread of human prostate cancer cells
3. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
4. Intensity Modulated Radiation Therapy optimal for localized prostate cancer
5. Study examines adverse effects among different radiation therapies for prostate cancer
6. Study Casts Doubt on Value of Pricey Prostate Cancer Therapy
7. Warren Buffett Has Early Stage Prostate Cancer
8. Majority of states fail to address youth exposure to alcohol marketing
9. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
10. PSA screening to detect prostate cancer can be beneficial to younger and at-risk men
11. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... , ... June 27, 2016 , ... Quality metrics are ... in many ways they remain in the eye of the beholder, according to experts ... publication of The American Journal of Managed Care. For the full issue, click ...
(Date:6/26/2016)... California (PRWEB) , ... June 26, 2016 , ... Pixel ... Cut Pro X. , "Film editors can give their videos a whole new perspective ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over ...
(Date:6/26/2016)... ... ... Kasmer, a legally blind and certified personal trainer is helping to develop a weight loss ... plans to fix the two major problems leading the fitness industry today:, ... , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, ... work on several important health care topics including advance care planning, healthcare costs ...
(Date:6/25/2016)... , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on ... Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ability ... fumigation is not a common occurrence, but a necessary one in the event that lice ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
(Date:6/23/2016)... -- In a startling report released today, National Safety Council ... comprehensive, proven plan to eliminate prescription opioid overdoses. Prescription ... are tackling the worst drug crisis in recorded U.S. history, assigned ... Kentucky , New Mexico , ... 28 failing states, three – Michigan , ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
Breaking Medicine Technology: