Navigation Links
Off-Label Use of Clotting Drug Soars, Report Finds
Date:4/18/2011

MONDAY, April 18 (HealthDay News) -- Hospitals are using a pricey blood-clotting drug in treating people who do not have hemophilia, a rare disorder in which blood does not clot normally -- even though its use in such patients is potentially risky, according to new research.

Stanford University researchers found that use of the drug, known as recombinant factor 7a, grew by 140 times from use in 125 cases in 2000 to 17,813 in 2008, with off-label uses accounting for most of the increase.

The $10,000-a-dose drug was used in people with hemophilia just 4 percent of the time, according to U.S. hospital statistics from 2000 to 2008. The rest of the time, it was used during heart surgery and to treat medical problems such as trauma and bleeding in the brain. The researchers content that such use puts patients at risk for heart attack and stroke because the drug can boost the risk of blood clots.

"The stakes are high with this one," Dr. Veronica Yank, an instructor in medicine at Stanford and the first author of one of two new studies on the drug, said in a university news release. "Because it's such a powerful clotting agent, it has the potential when used off-label to damage the lives of patients without providing any real benefit."

Yank and her colleagues said that physicians should be more cautious with the drug until there's more research into whether it's appropriate to use in certain cases.

The studies, published April 19 in Annals of Internal Medicine, are accompanied by a commentary from Harvard Medical School researchers, which says the research provides "compelling data about the runaway use, uselessness and risk for this expensive treatment."

The studies were funded by the U.S. Agency for Healthcare Quality and Research after previous research raised concerns that RF7a increased the risk for blood clots. The agency asked for an assessment of five off-label uses of RF7a: heart surgery, intracranial hemorrhage, body and brain trauma, liver transplantation and prostate surgery.

More information

The U.S. National Heart, Lung and Blood Institute has more on hemophilia.

-- Randy Dotinga

SOURCE: Stanford University School of Medicine, news release, April 18, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Hemophilia Drug Used Off-Label Raises Clot Risk
2. Anti-clotting agent does not improve outcomes of patients with severe pneumonia
3. New Anti-Clotting Drug May Work Better After Hip Replacement
4. Extended use of anti-clotting drug helps some bedridden patients
5. Tests to Measure Safety of Anti-Clotting Drugs of Limited Value
6. TBI Therapy and Nutrition: IOM report releases April 20
7. Boston University researchers find most substance-dependent individuals report poor oral health
8. Making temporary changes to brain could speed up learning, study reports
9. Aerobic Exercise May Curb Non-Alcoholic Fatty Liver Disease: Report
10. Brisk Walk Can Boost Blood Flow to the Brain: Report
11. U.S. Reports Drop in AIDS-Related Cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Off-Label Use of  Clotting Drug Soars, Report Finds
(Date:8/31/2020)... ... , ... Cardiothoracic surgeons at Allegheny General Hospital (AGH), part ... (CMU) to develop a new heart monitoring device designed to serve as an ... AGH/CMU team was recently awarded a “Trailblazer” grant from the National Institutes of ...
(Date:8/31/2020)... ... 2020 , ... Just found out your dear friend has cancer? , It’s hard to hear ... member shares their diagnosis. Once the shock wears off, the questions and fears can be ... the best ways to help? Words are failing me. I’m scared. I want to DO ...
(Date:8/31/2020)... ... August 31, 2020 , ... Want to get moving, break up your ... Foundation (CPARF) is thrilled to launch its fourth annual STEPtember campaign in the United ... STEPtember meets everyone wherever they are at this moment — encouraging people to move ...
(Date:8/31/2020)... ... 31, 2020 , ... Colorado State University Global (CSU Global) ... online education – is proud to announce its new master’s degree in ... kind in the nation, the 60-credit hour program is designed to provide students ...
(Date:8/31/2020)... ... ... topsy-turvy economic outlook continues to put financial strain on many of us, so it just ... our monthly expenses and put more into savings, if possible. , “That’s a great way ... net in place in case something were to happen to you,” says Lee Duncan, CMO ...
Breaking Medicine News(10 mins):
(Date:9/2/2020)... (PRWEB) , ... September 02, 2020 , ... U.S. ... Jonathan Lee . Dr. Lee will work at Bethesda Dermatopathology Lab. ... his B.A. from the University of California, Berkley. He went on to receive his ...
(Date:9/1/2020)... ... September 01, 2020 , ... Neil Oberfeld of ... Secretary to the Board of Trustees and committee chair of the Governance Committee ... a Denver-based nonprofit organization that fights for the education, health, and financial stability ...
(Date:9/1/2020)... ... 01, 2020 , ... September is National Ovarian Cancer Awareness Month. Ovarian ... other cancer of the female reproductive system. The American Cancer Society estimates that ... women will die from this disease. Throughout the month of September, Women’s Excellence ...
Breaking Medicine Technology: