Navigation Links
'Off-Label' Drug Use Appears Common
Date:4/16/2012

MONDAY, April 16 (HealthDay News) -- Off-label prescribing of medications is common, but the practice varies according to drug, and patient and doctor characteristics, a Canadian study finds.

In off-label prescribing, a doctor prescribes drugs for uses that have not been approved by regulators. For example, some medicines approved to treat depression are also prescribed for chronic pain.

The practice, which is legal but unregulated, is believed to contribute to preventable medication-related harm in patients, according to Dr. Tewodros Eguale, of McGill University in Montreal, and colleagues.

For the study, they examined more than 250,000 electronic prescriptions for more than 50,000 patients written from 2005 through 2009 by 113 doctors in a primary care network in Canada.

The study results were released online in advance of print publication in the journal Archives of Internal Medicine as part of the journal's health-care reform series.

About 11 percent of the medications were prescribed for off-label use, and 79 percent of off-label use lacked strong scientific evidence, the researchers found. The amount of off-label use in this study was less than in a previous U.S. study, the authors noted in a journal news release.

The investigators found that the highest rate of off-label use involved central nervous system drugs (26 percent), anti-infective agents (17 percent), and ear-nose-throat medications (15 percent). The study also found that drugs with three or four approved uses were less likely to be prescribed off-label than those with one or two approved uses.

Medications approved after 1995 were less likely to be prescribed off-label than those approved before 1981, and doctors with high scores on evidence-based practice were less likely to prescribe off-label, the findings showed.

"Our findings indicate that off-label prescribing is common in primary care and varies by drug class, the number of approved indications for the drug, the age of the drug, patients' sex and physicians' attitude toward evidence-based medicine," the researchers concluded.

"Electronic health records can be used to document treatment indication at the time of prescribing and may pave the way for enhanced post-marketing evaluation of drugs if linked to treatment outcomes," Eguale and colleagues wrote.

More information

The U.S. Agency for Healthcare Research and Quality has more about off-label prescribing.

-- Robert Preidt

SOURCE: Archives of Internal Medicine, news release, April 16, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Hemophilia Drug Used Off-Label Raises Clot Risk
2. Off-Label Use of Clotting Drug Soars, Report Finds
3. Mixed Results Seen With Off-Label Use of Antipsychotics
4. Protein Appears Key to Intestinal Balance
5. How health care is paid for appears to impact outcome
6. Hospitalization Appears to Help Personality Disorder Patients
7. Taking Flu Drugs While Pregnant Appears to Be Safe: Study
8. NAMI Medical Director Honored with APA Patient Advocacy Award; Appears in CNN Health and Huffington Post Columns
9. Celebrex Appears Easier on Stomach for Arthritis Patients
10. Plasma protein appears to be associated with development and severity of Alzheimers disease
11. FDA Panel Appears Skeptical Over Key Avandia Data
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Off-Label' Drug Use Appears Common
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... 2016 , ... Marcy was in a crisis. Her son James, eight, was out of control. ... and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... rocks at my other children and say he was going to kill them. If ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
(Date:6/23/2016)... Pa. , June 23, 2016 The ... in an outpatient dialysis facility.  Treatments are usually 3 ... 6 hours per visit, including travel time, equipment preparation ... a patient, but especially grueling for patients who are ... of a skilled nursing and rehabilitation centers for some ...
Breaking Medicine Technology: