Navigation Links
Odd Behaviors on Ambien Linked to Brain Circuitry
Date:7/2/2009

When the sleep aid shuts down one set of neurons, another set wakes up: study

THURSDAY, July 2 (HealthDay News) -- New information about brain circuit activity may help explain why some people who take the sleep aid Ambien (zolpidem) walk, eat, talk on the phone and even drive while not fully awake -- and without remembering it the next morning.

The drug has also been shown to awaken minimally conscious patients into a conscious state.

In experiments with mice, researchers at Georgetown University Medical Center in Washington, D.C., found that zolpidem shuts down some powerful brain circuits but activates other circuits when they're deprived of activity.

"Brain cells or neurons are highly reactive to incoming activity throughout life," study corresponding author Molly M. Huntsman, an assistant professor in the department of pharmacology, said in a news release.

"When brain activity is silenced, many neurons automatically react to this change. We see this in our study, which suggests that inhibitory neurons responsible for stopping neural activity are themselves shut down by zolpidem. The excitatory neurons, responsible for transmitting activity, are then allowed to re-awaken and become active again, without monitoring, because the inhibitory neurons are 'asleep'," she explained.

While it appears that zolpidem shuts down active neural pathways and perhaps triggers activity in others, the actual mechanism isn't known.

"Nevertheless, the paradoxical activation of brain circuits by a powerful sedative definitely needs more attention in additional studies in both human and animal models," Huntsman said.

The study was published in this week's Proceedings of the National Academy of Sciences journal.

More information

MedlinePlus has more about zolpidem.



-- Robert Preidt



SOURCE: Georgetown University Medical Center, news release, June 29, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cellular telephones to expand knowledge of health behaviors and microorganisms in adolescent males
2. Occupational Therapists Use Sensory Integration to Help Autistic Children Find Fitting Social Behaviors
3. Manny Tau, Psy.D. Promoted to Service Area Leader for the Problematic Behaviors Service Area at Baron Center, Inc
4. Parkinsons Drugs Can Trigger Unhealthy Behaviors
5. Parkinsons disease medication triggers destructive behaviors
6. Study finds cannabis use, dangerous driving behaviors interrelated
7. Reducing suicidal behaviors among adolescents
8. Owning alcohol-branded merchandise associated with teen drinking behaviors
9. Educational materials increase knowledge and behaviors important for preventing shaken baby syndrome
10. Top 5 Most Annoying Dental Patient Behaviors
11. The Largest and Most Comprehensive College Dating and Sex Survey Uncovers Surprising Behaviors of Students In and Out of the Bedroom
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Odd Behaviors on Ambien Linked to Brain Circuitry  
(Date:1/17/2017)... ... , ... For breast cancer clinicians and researchers who were unable to attend ... intimate review and analysis of its highlights, a novel half-day, complimentary meeting—the 14th Annual ... on February 4, 2017 in Chicago. Chaired by Kathy S. Albain, MD, FACP, FASCO ...
(Date:1/17/2017)... ... January 17, 2017 , ... SunView Software’s Service Smart Technology has been selected ... , Each year, Pink Elephant recognizes a new product or service developed ... specific business problem or opportunity. The award highlights original innovations that were released in ...
(Date:1/17/2017)... ... January 17, 2017 , ... Metro ... approach to infusing high speed technology into the fabric of an entire community. ... advancement of healthcare and wellness in a yet-to-be-named, health focused campus. Leading this ...
(Date:1/17/2017)... ... 2017 , ... Medic-CE , a Career Step company ... released four new continuing education courses as part of its Code3 CME Virtual ... classroom and meet the requirements of the National Continued Competency Program (NCCP), the ...
(Date:1/17/2017)... ... , ... A prescription medication bottle, pocket knife, luggage and a solar-powered aluminum ... Design Challenge , the Cradle to Cradle Products Innovation Institute has announced. ... to run through early 2018. The challenges are presented by the Institute in partnership ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... Indonesia , Jan. 17, 2017  With an annual growth ranging from 6% ... success. CPhI SEA (Jakarta International Expo, March 22-24, 2017) serves the industry ... What,s new at CPhI SEA 2017? Investment Forum ... Distributors, network Richer conference content Enhanced business matchmaking ... ...
(Date:1/18/2017)... , Jan. 18, 2017 Invetech, ... for cell and advanced therapies , has announced ... biopharmaceutical company developing "tumor starvation" treatments for acute ... needs. Under the agreement, Invetech will develop systems ... on Erytech,s proprietary ERYCAPS technology platform, which uses ...
(Date:1/18/2017)... MIAMI , January 18, 2017 ... announced the company plans to publish an online ... the Company,s preliminary sales forecast for 2017. Management ... Company,s trialing ninety-day record sales performance from its ... recently announced entry into the Cannabis sector ...
Breaking Medicine Technology: