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Ocular Pharma Company Charlesson Announces $2.35MM in New Funding
Date:10/17/2007

Oklahoma will enjoy the economic growth created by the infusion of research dollars in addition to the future growth we can anticipate based on Charlesson's discovery and R&D program. Macular degeneration and diabetic retinopathy impact Oklahomans in greater numbers per capita than they do populations of other states. Charlesson's success will have a positive impact on the future health of many Oklahomans. At OCAST, we are proud to support the peer-reviewed work conducted at Charlesson," said Michael Carolina, OCAST executive director.

Charlesson also received its seventh Phase I SBIR award from the NIH. This award provides funds of $237,000 to develop CLT-006 as a treatment for retinal neovascularization. CLT-006 is a small molecule that has demonstrated potent anti-angiogenic activity in vitro, and this grant will fund studies to demonstrate preclinical efficacy in several in vivo models. Preliminary data suggests that indications to treat AMD and Diabetic Retinopathy will be initially pursued for CLT-006. Additionally, Charlesson is developing safety and efficacy data for CLT-006 in numerous cancer models and plans to pursue other indications for treating cancer if the studies prove successful.

Diabetic Retinopathy (DR) is a most common complication of diabetes Mellitus and one of the four major sight-threatening conditions (cataract, age-related maculopathy, glaucoma, and Diabetic Retinopathy) in developed countries. Almost 100% of patients with type I and 60% of type II diabetic patients will develop some degree of retinopathy in their lifetime. Approximately 10% of diabetic patients develop a severe visual handicap after 15 years of diabetes. Retinopathy in diabetic patients is often preceded by Diabetic Macular Edema (DME) where vascular leakage leads to swelling of the retinal tissue. There are currently no FDA-approved treatments for treating DME.

Age-related Macular Degeneration (AMD) is a rapidly growing retinal disease which primarily
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SOURCE Charlesson, LLC
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