Navigation Links
Octreotide acetate does not prevent treatment-induced diarrhea in anorectal cancer
Date:3/24/2010

In many cancers, octreotide acetate (Sandostatin) has been reported to control the diarrhea that can accompany chemotherapy. However, for patients receiving combined chemotherapy and radiation for anal or rectal cancers, the drug proved no better than a placebo in a randomized trial that was published online March 24 in the Journal of the National Cancer Institute.

Chemotherapy and radiation, given concurrently, are standard treatments for anorectal cancers, which are diagnosed in about 46,000 people in the United States each year. The side effects of the combined therapy can include acute diarrhea, often so severe that patients must delay or discontinue treatment or be treated with lower doses, compromising the chances of cure.

To see whether octreotide acetate could reduce diarrhea in anorectal cancer patients, Babu Zachariah, M.D., Clement Gwede, Ph.D. and colleagues in the Radiation Therapy Oncology Group conducted a randomized, controlled, double-blinded trial. Patients were assigned to receive either a 30mg dose of long-acting octreotide or a placebo between 4 and 7 days before the start of radiation therapy and again about three weeks later. A total of 215 patients were included in the final analysis.

The rates of acute diarrhea were similar in the two groups. The researchers found no statistically significant differences in the number of patients who had to modify their treatment doses or schedules. There were likewise no differences between the groups in rates of hospitalization, usage of other medical resources, or quality of life.

"In this study," the authors conclude, "the prophylactic use of [long-acting octreotide acetate] did not prevent the incidence or reduce the severity of diarrhea and had no notable impact on patient-reported bowel function or quality of life."


'/>"/>

Contact: Caroline McNeil
caroline.mcneil@oxfordjournals.org
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. UCSF study finds clinic-based HIV prevention is effective in reducing risk behaviors
2. GSK Joins Global Vaccine Alliance to Help Prevent Millions of Children from Contracting Pneumococcal Disease in the Worlds Poorest Countries
3. 4 preventable risk factors reduce US life expectancy and lead to health disparities
4. 4 preventable risk factors reduce life expectancy in US and lead to health disparities
5. Ford CEO Asks Nation to March to Prevent Preterm Birth
6. Executive Order Will In No Way Prevent Federal Funding of Elective Abortion
7. Patients Who Take a Proton-Pump Inhibitor With Medicine to Prevent Blood Clots Are Less Likely to Be Hospitalized for Bleeding Ulcers
8. Preventive behaviors limited household transmission of H1N1 influenza during initial outbreak
9. Canadian Cattle Producers Willing to Make Changes to Prevent E. coli O157 Contamination on their Farms
10. Flexible Floor-Cleaning Routine Helps School Prevent Spread of Infection
11. Free Seminars to Help Employers Prevent Noise-Induced Hearing Loss Among Workers Set for Phoenix, Reno, Salt Lake City, Denver in May
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is ... emergency ambulance transport experience for the millions of people who require these medical ... the taxi industry through the use of technology. Now, SmartEMS has put forth ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet ... product that was developed to enhance the health of felines. The formula is all-natural ... two main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of ... recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at Work ... Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, ... at his family verbally and physically. , “When something upset him, he couldn’t control his ... it. He would throw rocks at my other children and say he was going to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, a ... invasive and more durable cerebrospinal fluid treatments, today ... The Series-A funding is led by Innova Memphis, ... and other private investors.  Arkis, new financing will ... and the market release of its in-licensed Endexo® ...
Breaking Medicine Technology: