Navigation Links
'Obscurins' in breast tissue may help physicians predict and detect breast cancer
Date:3/21/2012

Bethesda, MDA new discovery published online in The FASEB Journal (http://www.fasebj.org) may lead to a new tool to help physicians assess breast cancer risk as well as diagnose the disease. In the report, researchers from Johns Hopkins University and the University of Maryland, explain how proteins, called "obscurins," once believed to only be in muscle cells, act as "tumor suppressor genes" in the breast. When their expression is lost, or their genes mutated in epithelial cells of the breast, cancer develops. It promises to tell physicians how breast cancer develops and/or how likely it is.

"Our studies on the role of obscurins in the development of breast cancer lay the framework for a series of in-depth investigations aiming to understand how these proteins act to prevent tumor formation," said Aikaterini Kontrogianni-Konstantopoulos, Ph.D., a researcher involved in the work from the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine in Baltimore, MD. "It is our hope that our research will provide important new insights into breast tumor biology and ultimately yield new targets for the development of innovative therapeutic strategies."

To make this discovery, Kontrogianni-Konstantopoulos and colleagues used a highly specific antibody probe to detect obscurins in normal and cancerous breast, skin, and colon cells. They observed that cancer cells expressed significantly lower amounts of obscurins compared to normal cells, leading to the hypothesis that loss of obscurins allowed normal cells to become cancerous. The researchers then compared two breast epithelial cell populations: a "normal" one, which expressed obscurins and served as a control, and an "altered" one, which failed to express obscurins through genetic manipulations. Both cell populations were treated with a chemical called "etoposide," which causes massive DNA damage and induces cell death. Scientists detected and quantified cell death with a number of different methodologies, and found that etoposide caused a significantly high percentage of cell death in normal cells, but only a very low percentage of cell death in the altered, obscurin-deficient cells. This suggests that the loss of obscurins makes breast epithelial cells more resistant to the natural cell death necessary to prevent damaged cells from transforming into a run-away cancer.

"This study is important for a number of reasons. First, it shows that there is a lot more to obscurins than previously thought, making future research into this family of proteins important. Second, it reveals a previously unknown group of tumor suppressors in the breast that prevent normal cells from becoming cancerous. Finally, it opens doors to new tools to help doctors assess a person's risk for cancer and possibly to diagnose it in the earliest of stages," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal.


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Low forms of cyclin E reduce breast cancer drugs effectiveness
3. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
4. For Some Breast Cancer Patients, Shorter Radiation Works Well
5. Short-term radiation therapy successful on breast cancer
6. Few Women at High Risk for Breast Cancer Take Tamoxifen
7. Hormone May Prevent Aggressive Breast Cancer
8. MSU researcher linking breast cancer patients with alternative therapies
9. MRI May Not Add Value to Routine Breast Cancer Care
10. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
11. Businesses Rally Big Efforts to Benefit the Susan G. Komen Phoenix Affiliates Fight Against Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users ... - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 ... Pro X . Simply select a ProHand generator and drag it above media or ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June ... -based mobile pulmonary function testing company, is now able to ... devices developed by ndd Medical Technologies , Inc. ... done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ... , can get any needed testing done in the comfort of ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
Breaking Medicine Technology: