Navigation Links
Obesity ups cancer risk, and here's how
Date:1/21/2010

Obesity comes with plenty of health risks, but there's one that's perhaps not so well known: an increased risk of developing cancer, and especially certain types of cancer like liver cancer. Now, a group of researchers reporting in the January 22nd issue of the journal Cell, a Cell Press publication, have confirmed in mice that obesity does indeed act as a "bona fide tumor promoter." They also have good evidence to explain how that happens.

"Doctors always worry about our weight, but the focus is often on cardiovascular disease and type 2 diabetes, both of which can be managed pretty well with existing drugs," said Michael Karin of the University of California, San Diego. "However, we should also worry about elevated cancer risk. If we can reduce cancer deaths by as many as 90,000 per year, that's a lot of people a lot of lives."

Karin's team shows that liver cancer is fostered by the chronic inflammatory state that goes with obesity, and two well known inflammatory factors in particular. The findings suggest that anti-inflammatory drugs that have already been taken by millions of people for diseases including rheumatoid arthritis and Crohn's disease may also reduce the risk of cancer in those at high risk due to obesity and perhaps other factors as well, Karin said.

The epidemiological studies reported earlier showed that obese people have about a 1.5-fold increase in their risk of cancer overall. That may not necessarily sound like a lot, Karin said, but it equates to about 90,000 extra cancer deaths per year in the United States alone. When it comes to liver cancer, the study showed obese people have a 4.5-fold greater risk.

Given the apparent connection between obesity and liver cancer in particular, Karin's team decided to investigate in mice prone to develop hepatocellular carcinoma (HCC). The mice are typically given HCC either by exposure to a chemical carcinogen, known as DEN, when they are two weeks old, or
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Virus Could Help Drive Obesity
2. Surgery for severe obesity saves lives
3. Obesity Doesnt Always Equal Diabetes
4. Obesity Rate in U.S. Still Climbing
5. Treating diabetes during pregnancy can break link to childhood obesity
6. ZIP codes and property values predict obesity rates
7. High and mighty: first common height gene identified by researchers behind obesity gene finding
8. Research Links TV/Video Game Playing With Child Obesity; Health Experts Back a New Approach
9. UT Southwesterns obesity research receives $22 million NIH Roadmap grant
10. Genaera Announces Formation of Scientific Advisory Board for Obesity Drug Candidate Trodusquemine (MSI-1436)
11. Cities Say Restaurant Nutrition Information Crucial in Fighting Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... Alan Mozes HealthDay Reporter ... take note: Many American parents are aware of online physician-rating ... a pediatrician for their children, according to a new national ... than 1,600 parents -- further suggest that negative online ratings ... doctor has been recommended by a neighbor. Conversely, a ...
(Date:9/22/2014)... Asians living in Canada have a higher rate of ... with while people, McMaster researchers have found. , ... Medical Association Journal (CMAJ Open) and may be ... fastest-growing ethnic groups in the country is the more ... comprising about three percent of the population. They include ...
(Date:9/22/2014)... Kessler researchers have published a pilot study showing ... in people with multiple sclerosis (MS). Improvements ... stress, and pain. "Development and effectiveness of ... MS: Description and outcomes" was epublished ahead of ... Journal of MS Care (doi: 10.7224/1537-2073.2013-045). The ...
(Date:9/22/2014)... new prescription devices approved by the U.S. Food and ... with migraine headaches who don,t tolerate migraine medications well, ... the Cefaly -- is designed to prevent migraines, while ... to be used when migraines first start, according to ... for alternative migraine treatments. Because these devices aren,t ingested ...
(Date:9/22/2014)... (PRWEB) September 22, 2014 Severe weather can occur ... time. That’s why, as part of National Preparedness Month, Amica ... your family prepare for the unexpected:, , Build ... as nonperishable food and one gallon of water per person per ... Create an evacuation plan that includes pets so your family knows ...
Breaking Medicine News(10 mins):Health News:Many Parents Use Online Ratings to Pick a Pediatrician, Study Finds 2Health News:Many Parents Use Online Ratings to Pick a Pediatrician, Study Finds 3Health News:Higher risk of heart disease for South Asians in Canada 2Health News:Noninvasive Devices May Help Migraines, FDA Says 2Health News:Amica Shares Tips for National Preparedness Month 2
... N.J., Feb. 17 Novo Nordisk, a global healthcare ... of Andy Ajello as vice president for National Diabetes ... Executive Team and will report directly to Jerzy Gruhn, ... recently the associate vice president of Diabetes Sales for ...
... Little known language in the economic stimulus ... efforts by nonprofit hospitals - resulting in fewer ... of essential health care services provided to the ... the 11th hour thanks to the efforts of ...
... CryoLife, Inc. (NYSE: CRY ), a,biomaterials, medical ... Food and Drug Administration (FDA) has cleared a new ... The new labeling claim,relates to reducing a component of ... CryoValve SG pulmonary human heart ...
... Year,s Most Common ClaimsBREA, Calif., Feb. 17 Not ... and cuddly. Take ear infections, for example, or skin ... (VPI), the nation,s oldest and largest provider of pet ... to find the year,s most common pet maladies. The ...
... "natural" ingredients should be regarded as a driver for ... 17 According to Kline & Company,s study ... 2008: U.S. and Europe , botanicals consumption is growing ... average growth of 5.4%. The increased use of botanicals ...
... DIEGO, Feb. 17 Tracon Pharmaceuticals, a biotechnology company ... announced today that its three clinical stage cancer therapeutics ... 100th Annual Meeting of the American Association for Cancer ... program targets a unique pathway with the potential for ...
Cached Medicine News:Health News:Novo Nordisk Appoints Andy Ajello as Vice President for National Diabetes Sales, Managed Care and Government Accounts 2Health News:Philanthropic Fundraising Activities in Stimulus Bill Preserved Thanks to the Efforts of the Association for Healthcare Philanthropy 2Health News:FDA Clears New Immune Response Claim for the CryoValve(R) SG Pulmonary Human Heart Valve 2Health News:FDA Clears New Immune Response Claim for the CryoValve(R) SG Pulmonary Human Heart Valve 3Health News:Sick as a Dog: Pets' Top Medical Conditions of 2008 2Health News:Sick as a Dog: Pets' Top Medical Conditions of 2008 3Health News:Desire for Performance Coupled With Natural Ingredients Boosts Botanical Actives Consumption in Personal Care 2Health News:Desire for Performance Coupled With Natural Ingredients Boosts Botanical Actives Consumption in Personal Care 3Health News:Tracon Pharmaceuticals to Present Clinical Stage Programs at AACR 2009 2Health News:Tracon Pharmaceuticals to Present Clinical Stage Programs at AACR 2009 3
(Date:9/22/2014)... , Sept. 22, 2014  Aethlon Medical, Inc. ... devices to address infectious disease, cancer and other ... Research Projects Agency (DARPA) has informed the Company ... proceed with year four of a five-year $5.9 ... September 30, 2011 under DARPA,s Dialysis-Like Therapeutics (DLT) ...
(Date:9/22/2014)... , Sept. 22, 2014 /PRNewswire/-- CANTEL MEDICAL CORP. (NYSE: ... quarter and fiscal 2014 ended July 31, 2014 on Monday, ... call to discuss the results at 11:00 AM ET. Participating ... Chairman; Andrew A. Krakauer , President and CEO; ... Craig A. Sheldon , Senior Vice President, CFO and Treasurer; ...
(Date:9/22/2014)... SAN FRANCISCO , Sept. 22, 2014  Sutro ... FierceBiotech as one of 2014,s Fierce 15 ... promising private biotechnology companies in the industry.  ... A-list group of backers as well as industry partners ... developing antibody-drug conjugates and bispecifics," says John Carroll ...
Breaking Medicine Technology:Aethlon Medical Receives Notice of DARPA Contract Renewal 2Aethlon Medical Receives Notice of DARPA Contract Renewal 3Aethlon Medical Receives Notice of DARPA Contract Renewal 4Cantel Medical Corp. To Hold Conference Call To Discuss Results For Its Fourth Quarter And Fiscal 2014 Ended July 31, 2014 2FierceBiotech names Sutro Biopharma as one of its "Fierce 15" Biotech Companies of 2014 2FierceBiotech names Sutro Biopharma as one of its "Fierce 15" Biotech Companies of 2014 3
... March 22 Cambrex Corporation (NYSE: ... a privately held company that is a leader in ... Wiesbaden, Germany and offers cost effective customized ... pharmaceutical industry, with the ability to utilize its tool ...
... Inc. (OTC Bulletin Board: GOVX), a biotechnology company that is developing and testing innovative HIV/AIDS vaccines, has engaged The Investor Relations Group ("IRG"), ... , ... , ... ...
Cached Medicine Technology:Cambrex Acquires IEP GmbH 2Cambrex Acquires IEP GmbH 3GeoVax Labs Engages The Investor Relations Group 2GeoVax Labs Engages The Investor Relations Group 3GeoVax Labs Engages The Investor Relations Group 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: