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Obesity raises risks of serious digestive health concerns
Date:8/19/2008

colorectal adenoma in 7,963 Japanese patients who underwent colonoscopy between 1991 and 2003. Patients who had a family history of colorectal cancer, colorectal polyps, inflammatory bowel disease, colorectal surgery or who took NSAIDS were excluded from the study.

In this cross-sectional study, patients were classified into four groups according to their body mass index (BMI). Researchers found 20.7 percent of patients had at least one colorectal adenoma. Importantly, as the BMI increased, so did the prevalence of colorectal adenomas.

In a separate cohort analysis, 2,568 patients from the initial study underwent a second colonoscopy after one year to compare the effect of body weight changes on the development of new colorectal adenomas. The incidence rates of colorectal adenoma were 9.3 percent in patients who lost 5 percent or more in body weight; 16.2 percent in patients who gained 5 percent or more in body weight; and 17.1 percent in patients who neither gained nor lost weight.

Weight loss was associated with lowered incidence of adenoma, independent of gender, age, initial colonoscopic findings, and initial BMI. Based on their findings, the authors suggest that controlling body weight may decrease the risk of developing colorectal adenomas.

According to ACG President Amy E. Foxx-Orenstein, D.O., FACG, "The magnitude of the obesity epidemic adds a staggering burden to our current health care system. These studies point to the serious potential risks of GI disease for individuals who are overweight or obese."


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Contact: Rosanne Riesenman
rriesenman@acg.gi.org
301-263-9000
American College of Gastroenterology
Source:Eurekalert

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