Navigation Links
Obesity primes the colon for cancer, according to NIH study
Date:4/1/2014

Obesity, rather than diet, causes changes in the colon that may lead to colorectal cancer, according to a study in mice by the National Institutes of Health. The finding bolsters the recommendation that calorie control and frequent exercise are not only key to a healthy lifestyle, but a strategy to lower the risk for colon cancer, the second leading cause of cancer-related death in the United States.

Paul Wade, Ph.D., and Thomas Eling, Ph.D., scientists at the National Institute of Environmental Health Sciences (NIEHS), part of NIH, led a collaborative team that made the discovery. The study appeared online April 1 in the journal Cell Metabolism.

A large body of scientific literature says people who are obese are predisposed to a number of cancers, particularly colorectal cancer, Eling said. To better understand the processes behind this link, he and his colleagues fed two groups of mice a diet in which 60 percent of the calories came from lard. The first group of mice contained a human version of a gene called NAG-1, which has been shown to protect against colon cancer in other rodent studies. The second group lacked the NAG-1 gene.

The NAG-1 mice did not gain weight after eating the high-fat diet, while mice that lacked the NAG-1 gene grew plump.

The researchers noticed another striking difference between the two groups of animals.

"The obese mice exhibited molecular signals in their gut that led to the progression of cancer, but the NAG-1 mice didn't have those same indicators," Eling said.

The researchers looked for molecular clues, by isolating cells from the colons of the mice and analyzing a group of proteins called histones. Histones package and organize DNA in a cell's nucleus, and sometimes undergo a process known as acetylation, in which chemical tags bind to their surface. The pattern of acetylation varies depending on the chemical processes taking place in the cell.

Wade explained that the acetylation patterns for the obese mice and the thin NAG-1 mice were drastically different. Patterns from the obese mice resembled those from mice with colorectal cancer. The additional weight they carried also seemed to activate more genes that are associated with colorectal cancer progression, suggesting the obese mice are predisposed to colon cancer.

"Any preexisting colon lesions in these animals are more likely to evolve rapidly into malignant tumors," Wade said. "The same thing may happen in humans."

Wade and Eling want to find out exactly how obesity prompts the body to develop colorectal cancer. Wade said that the likely candidates for triggering tumor growth in the colon are fat cells, but there are many more possibilities. Finding these cellular switches may give rise to production of medications to keep people from getting colorectal cancer.

"Once we identify the signaling pathways and understand how the signal is transduced, we may be able to design ways to treat colorectal cancer in obese patients," Wade said.


'/>"/>

Contact: Robin Arnette
arnetter@niehs.nih.gov
919-541-5143
NIH/National Institute of Environmental Health Sciences
Source:Eurekalert

Related medicine news :

1. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
2. Obesitys Health Costs Double Earlier Estimates
3. Troubled Homes May Fuel Obesity in Girls
4. Childhood Obesity May Raise Odds of Adult Liver Cancer
5. Could the Childhood Obesity Epidemic Be Ebbing?
6. New research finds no association between white potato consumption (baked, boiled mashed) and obesity, Type 2 diabetes or systemic inflammation
7. Mayo Clinic: Obesity epidemic fueling rise in rheumatoid arthritis among women
8. Treating childhood obesity: A family affair
9. Rising Obesity Rates Might Mean More Rheumatoid Arthritis
10. Research May Point to New Obesity Treatments
11. U.S. Obesity Rate Set to Soar, Costing Billions: CDC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... ... May 23, 2017 , ... Diagnotes, an Indianapolis-based digital healthcare ... on its secure clinical communication platform. The platform allows clinicians to easily escalate ... type and urgency of a situation. , “We know from our daily ...
(Date:5/23/2017)... ... May 23, 2017 , ... Therachat , a smart guided journaling tool ... on the current state of anxiety in support of National Mental Health Awareness Month. ... April 2017 and benchmarked general anxiety levels as well as identified the top triggers, ...
(Date:5/22/2017)... ... May 22, 2017 , ... Today, Our Urgent Care celebrates the grand opening ... ribbon cutting ceremony. Since opening over a month ago, Our Urgent Care Washington ... The new Our Urgent Care walk-in clinic is located at 3195 Phoenix Center ...
(Date:5/22/2017)... ... May 22, 2017 , ... WeightZone Factor a popular ... Factor members to track their exercise patterns, monitor behavioral changes, employ biometric monitoring, ... their mobile phones. It also provides social networks for members with similar interests ...
(Date:5/21/2017)... ... 20, 2017 , ... Pixel Film Studios presents a set ... Final Cut Pro X. The business-oriented elements and dignified animations are designed to ... will deliver a professional and distinguished look to any multi-line text animation within ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... , May 4, 2017 Clarius ... its wireless, handheld ultrasound scanners this week at ... Scientific Meeting (ACOG) in San Diego, ... "Clarius is the perfect tool for ... and heart rate, and evaluate pregnancy-related complications like ...
(Date:5/4/2017)... May 4, 2017   BioLife Solutions , Inc. ... and marketer of proprietary clinical grade hypothermic storage ... the "Company"), today announced that the Company,s first quarter ... on Thursday, May 11, 2017, and that the Company ... 1:30 p.m. PT that afternoon. Management will provide an ...
(Date:5/3/2017)... 3, 2017  West Pharmaceutical Services, Inc. (NYSE: ... injectable drug administration, announced today that Fran ... Services, and Diane Paskiet , Director, Scientific ... focused on West,s expertise in the areas of ... as providing commentary on updated industry guidance. ...
Breaking Medicine Technology: