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Obesity-induced fatty liver disease reversed in mice
Date:1/29/2014

activating AMPK. To test this theory, they added four chemically modified versions of the drug to the cells and found that the derivatives were able to activate AMPK without valproic acid. In fact, they achieved higher activation of AMPK at one-fortieth the concentration.

To assess the uptake and breakdown of valproic acid in living organisms, they gave the drug to obese mice with high blood sugar levels, fatty livers and rapid weight gain. Treated mice showed decreased blood sugar levels, decreases in the size and the fat accumulation of their livers, and a stabilization of weight rather than the continued weight gain experienced by untreated mice.

"The improvements seen in the health of these obese mice were very encouraging," says Bumpus. "We hope that we will find similar results in obese people who take valproic acid."


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Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

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