Navigation Links
Obesity-induced fatty liver disease reversed in mice
Date:1/29/2014

Johns Hopkins researchers have discovered that valproic acid, a widely prescribed drug for treating epilepsy, has the additional benefits of reducing fat accumulation in the liver and lowering blood sugar levels in the blood of obese mice. A summary of their research appears in this month's issue of the journal Molecular Pharmacology.

Fatty liver disease can lead to liver failure and is often caused by obesity and a high-fat diet. Obesity is also associated with the development of type 2 diabetes, which sabotages the body's process for controlling blood sugar levels. A rapidly rising problem in the developed world, obesity currently affects over 90 million Americans.

Studying the ways in which the cytochrome P450 family of enzymes processes valproic acid, the Johns Hopkins biochemists found that it can activate the protein AMPK, which was already known to be a good drug target for treating metabolic disorders like type 2 diabetes and obesity.

The Bumpus laboratory studies how drugs are processed in cells by enzymes of the cytochrome P450 family. Humans have 57 of these enzymes, and several of them work on the drug valproic acid. In the course of their research, Namandj Bumpus, Ph.D., assistant professor of pharmacology, and postdoctoral fellow Lindsay Avery, Ph.D., found that valproic acid could activate AMPK in mouse and human liver cells in a dose-dependent way.

"It was exciting to find that valproic acid can activate AMPK," Bumpus says. "What's even better is that its byproducts can activate AMPK at much lower doses. That's a desirable quality if you want to eventually use it to treat people."

Knowing that valproic acid is extensively processed by cytochrome P450 enzymes, the research team added a cytochrome P450 inhibitor to mouse and human liver cells and found that AMPK was no longer activated. This suggested that the byproducts of valproic acid, as opposed to valproic acid itself, were the molecules
'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Fatty acid found in fish prevents age-related vision loss: U of A medical research
2. Pictures of Fatty, Sugary Foods May Spur Cravings
3. Girls with eating disorders regain healthy fatty acid levels when their weight normalizes
4. Analysis of conflicting fish oil studies finds that omega-3 fatty acids still matter
5. Scripps Florida scientists develop new compound that reverses fatty liver disease
6. Limiting polyunsaturated fatty acid levels in pregnancy may influence body fat of children
7. Fatty Liver Treatment
8. How “Fatty Liver Diet Guide” Helps People Treat Fatty Liver Quickly – Vkool.com
9. Omega-3 fatty acids more effective at inhibiting growth of triple-negative breast cancer
10. Scarring May Raise Death Risk From Fatty Liver Disease
11. Gene variant ID could lead to better fatty liver disease diagnosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Obesity-induced fatty liver disease reversed in mice
(Date:7/23/2014)... ( FXS ) is a genetic disorder that causes ... autistic spectrum, as well as cognitive deficits. It is ... the most common cause of autism. , Now biomedical ... a study that sheds light on the ... (July 23) in the Journal of Neuroscience , ...
(Date:7/23/2014)... Kathleen Doheny HealthDay Reporter ... surgery appears to have an additional side benefit -- ... to a new study. The study found that ... reported having incontinence prior to the procedure. After surgery, ... improved or disappeared, said study researcher Dr. Leslee Subak, ...
(Date:7/23/2014)... the genome resulting from a combination of genetic modifications ... weak predispositions to developing certain kinds of cancer; in ... throughout our lifetime. Although the genetic origins of cancers ... not able to measure the role of non-coding regions ... from the University of Geneva (UNIGE), by studying tissues ...
(Date:7/23/2014)... 2014 A therapy combining salmon fibrin injections into ... into the brain restored voluntary motor function impaired by ... Center have found. , In a study on rodents, ... turning back the developmental clock in a molecular pathway ... and providing a scaffold so that neuronal axons at ...
(Date:7/23/2014)... Recently, Agebc.com has launched its new collection of ... a promotion of wedding dresses. According to a representative ... end of this month. , The beautiful wedding dresses ... mermaid, ball-gown, empire, and more. Agebc.com is a well-known ... for women, and the company is devoted to providing ...
Breaking Medicine News(10 mins):Health News:Study links enzyme to autistic behaviors 2Health News:Study links enzyme to autistic behaviors 3Health News:Weight Loss Surgery May Help Ease Urinary Incontinence 2Health News:Weight Loss Surgery May Help Ease Urinary Incontinence 3Health News:Genetics of cancer: Non-coding DNA can finally be decoded 2Health News:Gene inhibitor, salmon fibrin restore function lost in spinal cord injury 2Health News:Agebc.com Launched Its New Collection of Wedding Dresses 2
... ... beings need music as a form of release and expression, and now it has been ... ... stressors, stimuli, and distractions in this world, it can be difficult for the average person ...
... Huge ... ... Almac has addressed ongoing industry developments by greatly expanding their capacity in the New ... in the pharmaceutical industry, specifically the growing demand for biologics. Biologics, which are ...
... ... announced today it has acquired Canterbury International, a privately-held company based ... furnishings. The Verdin Company, based in Cincinnati, Ohio, is recognized ... and clock towers, glockenspiels, and other musical instruments.,Canterbury International, a leading ...
... ... and Profitability. , ... Manasquan, NJ, USA (PRWEB) June 21, 2010 -- Marketers with sufficient insight to estimate ... untapped profit potential, according to the 2010 Lenskold Group / emedia Lead ...
... ... industry. Anyone who can understand this contradiction, will understand the sense of urgency related to ... now, keeping BP’s oil spill and the effects of it in mind. , ... (PRWEB) June 20, 2010 -- BP’s oil ...
... ... profession will come together to share knowledge and explore innovations in one of the most ... ... unique conferences offering high-quality scientific programs, which broaden perspectives by exploring the latest innovations in ...
Cached Medicine News:Health News:Reinvent your Mental State With Brainwave Entrainment Relaxation Music 2Health News:Reinvent your Mental State With Brainwave Entrainment Relaxation Music 3Health News:Reinvent your Mental State With Brainwave Entrainment Relaxation Music 4Health News:Almac's US Headquarters Will Address Capacity Demand for Clinical Supplies 2Health News:The Verdin Company Acquires Canterbury International, an industry leader in architectural site furnishings for over 50 years 2Health News:The Verdin Company Acquires Canterbury International, an industry leader in architectural site furnishings for over 50 years 3Health News:Lead Generation Marketing ROI Study Released 2Health News:Lead Generation Marketing ROI Study Released 3Health News:Lead Generation Marketing ROI Study Released 4Health News:Wind turbines harmful for the environment and public health 2Health News:The 2nd Future Trends in Implantology International Dental Conference 2
(Date:7/23/2014)... July 23, 2014 /PRNewswire-iReach/ -- Top Staten Island Pediatrician ... his feedback on article, which discusses tips for parents about ... According to US News ... death among American children aged 1 to 4, and can ... One expert in the article says that watching a ...
(Date:7/23/2014)... July 23, 2014 Inovio Pharmaceuticals, ... results from its randomized, double-blind, placebo-controlled phase ... biopsy-proven cervical intraepithelial neoplasia 2/3 (CIN2/3) associated ... 18. Treatment with VGX-3100, Inovio,s HPV16/18-specific immunotherapy, ... CIN1 or no disease, meeting the study,s ...
(Date:7/23/2014)... , July 23, 2014  The management team ... ) will hold a conference call on July ... second quarter ended June 30, 2014.  The call ... 2014Time: , 8:30 am EDTDial-in numbers: , Toll ... (412) 317-0790Webcast (live & archive): , www.columbialabs.com ...
Breaking Medicine Technology:Premier Staten Island Pediatrician Dr. Michael Gabriel Comments On Article Discussing Pool Safety Tips for Parents 2Inovio Pharmaceuticals HPV Immunotherapy Achieves Primary Efficacy Endpoint in Randomized Phase II Cervical Dysplasia Trial 2Inovio Pharmaceuticals HPV Immunotherapy Achieves Primary Efficacy Endpoint in Randomized Phase II Cervical Dysplasia Trial 3Inovio Pharmaceuticals HPV Immunotherapy Achieves Primary Efficacy Endpoint in Randomized Phase II Cervical Dysplasia Trial 4Inovio Pharmaceuticals HPV Immunotherapy Achieves Primary Efficacy Endpoint in Randomized Phase II Cervical Dysplasia Trial 5Columbia Laboratories to Discuss Second Quarter 2014 Financial Results on July 31st Conference Call 2
... , PALO ALTO, Calif., Dec. 2 ... 25, 2009, Varian, Inc. filed with the U.S. Securities and Exchange ... ended October 2, 2009. This Annual Report may be accessed ... and "SEC Filings," and then on "10-K" in the table shown. ...
... , ST. LOUIS, Dec. 2 KV Pharmaceutical Company ... an employment agreement with Interim President and Chief Executive Officer ... 2011. Mr. Van Vliet has served as Interim President and ... provides continuity of senior leadership as the Company seeks to ...
Cached Medicine Technology:KV Pharmaceutical Enters Into Employment Agreement with Interim President and Chief Executive Officer David A. Van Vliet 2
Diamond Filter Tips play a critical role in preventing aerosol-borne contamination. Also available sterilized (no need to autoclave) and certified free of detectable RNase, DNase, DNA, RNA, and prote...
10 L, Racked, Pre-sterilized, 96 tips/rack Recommended for 2, 5 and 10 L pipettes....
... are ideal for PCR and ... any work where aerosol contamination ... for pipetting DNA/RNA solutions, infectious ... For applications requiring absolute sterility, ...
Avant E-Z Rack Premium Low Binding 10 l Pipet Tips are accurate, contamination free, and allow quantitative transfer of your samples without relying on silicone....
Medicine Products: